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0EZH1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEZH1
DescriptionEnhancer of zeste homolog 1 (enx-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003682 chromatin binding (TAS)
0009653 morphogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The SET domain appears generally as one part of a larger multidomain protein.nd recently there were described three structures of very different proteins with distinct domain compositions: Neurospora crassa DIM-5. member of the Su(var) family of HKMTs which methylate histone H3 on lysine 9.uman SET7 (also called SET9).hich methylates H3 on lysine 4 and garden pea Rubisco LSMT.n enzyme that does not modify histones.ut instead methylates lysine 14 in the flexible tail of the large subunit of the enzyme Rubisco. The SET domain itself turned out to be an uncommon structure. Although in all three studies.lectron density maps revealed the location of the AdoMet or AdoHcy cofactor.he SET domain bears no similarity at all to the canonical/AdoMet-dependent methyltransferase fold. Strictly conserved in the C-terminal motif of the SET domain tyrosine could be involved in abstracting a proton from the protonated amino group of the substrate lysine.romoting its nucleophilic attack on the sulphonium methyl group of the AdoMet cofactor. In contrast to the AdoMet-dependent protein methyltranferases of the classical type.hich tend to bind their polypeptide substrates on top of the cofactor.t is noted from the Rubisco LSMT structure that the AdoMet seems to bind in a separate cleft.uggesting how a polypeptide substrate could be subjected to multiple rounds of methylation without having to be released from the enzyme. In contrast.ET7/9 is able to add only a single methyl group to its substrate. It has been demonstrated that association of SET domain and myotubularin-related proteins modulates growth control . The SET domain-containing Drosophila melanogaster (Fruit fly) protein.nhancer of zeste.as a function in segment determination and the mammalian homologue may be involved in the regulation of gene transcription and chromatin structure.Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. Histone lysine methyltransferases (HMTase) differ both in their substrate specificity for the various acceptor lysines as well as in their product specificity for the number of methyl groups (one.wo.r three) they transfer. With just one exception .he HMTases belong to SET family that can be classified according to the sequences surrounding the SET domain . Structural studies on the human SET7/9. mono-methylase.ave revealed the molecular basis for the specificity of the enzyme for the histone-target and the roles of the invariant residues in the SET domain in determining the methylation specificities . The pre-SET domain.s found in the SUV39 SET family.ontains nine invariant cysteine residues that are grouped into two segments separated by a region of variable length. These 9 cysteines coordinate 3 zinc ions to form to form a triangular cluster.here each of the zinc ions is coordinated by 4 four cysteines to give a tetrahedral configuration. The function of this domain is structural.olding together 2 long segments of random coils.The C-terminal region including the post-SET domain is disordered when not interacting with a histone tail and in the absence of zinc. The three conserved cysteines in the post-SET domain form a zinc-binding site when coupled to a fourth conserved cysteine in the knot-like structure close to the SET domain active site . The structured post-SET region brings in the C-terminal residues that participate in S-adenosylmethine-binding and histone tail interactions. The three conserved cysteine residues are essential for HMTase activity.s replacement with serine abolishes HMTase activity .
  IPR001214:SET
The retroviral oncogene v-myb.nd its cellular counterpart c-myb.ncode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognize the sequence YAAC(G/T)G . In myb.ne of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding .
  IPR001005:Myb, DNA-binding
IPR001214:SET 
Evalue:-51.6382713317871 
Location:607-734IPR001005:SANT 
Evalue:-3.53760200210104 
Location:430-478IPR001005:SANT 
Evalue:1.64345267648619 
Location:135-263
SequencesProtein: EZH1_HUMAN (747 aa)
mRNA: NM_001991
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 773 residues, 38105819-38108136Exon2: 30 residues, 38108420-38108505Exon3: 29 residues, 38109283-38109364Exon4: 29 residues, 38110145-38110227Exon5: 34 residues, 38110631-38110727Exon6: 61 residues, 38111550-38111729Exon7: 44 residues, 38113501-38113627Exon8: 15 residues, 38114419-38114460Exon9: 32 residues, 38115389-38115481Exon10: 67 residues, 38117832-38118029Exon11: 62 residues, 38118752-38118933Exon12: 32 residues, 38123519-38123611Exon13: 56 residues, 38123997-38124161Exon14: 36 residues, 38124648-38124751Exon15: 61 residues, 38125816-38125993Exon16: 42 residues, 38128338-38128459Exon17: 42 residues, 38129848-38129968Exon18: 45 residues, 38133178-38133307Exon19: 44 residues, 38134368-38134496Exon20: 32 residues, 38136371-38136462Exon21: 8 residues, 38150554-38150574Exon22: 2 residues, -Jump to EZH1_HUMAN  
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Loci Cluster (Details)Loci: 4288 37562438-37586822 ~-24K 15872(KCNH4)(-)Loci: 4289 37589603-37590996 ~-1K 15873(HCRT)(-)Loci: 3002 37864387-37928122 ~-64K 15882(ATP6V0A1)(+)Loci: 3003 37941476-37949990 ~-9K 15887(NAGLU)(+)Loci: 3004 38064836-38072549 ~-8K 15898(TUBG2)(+)Loci: 3005 38088157-38105358 ~-17K 15903(CNTNAP1)(+)Loci: 4290 38105819-38150574 ~-45K 15904(EZH1)(-)Loci: 3006 38186221-38202605 ~-16K 15907(WNK4)(+)Loci: 4291 38215677-38229807 ~-14K 15912(BECN1)(-)Loci: 3007 38250134-38256248 ~-6K 15916(AOC2)(+)Loci: 3008 38256726-38263664 ~-7K 15917(AOC3)(+)Loci: 4292 38420147-38427921 ~-8K 15927(VAT1)(-)Loci: 4293 38449839-38530657 ~-81K 15931(BRCA1)(-)Loci: 4287 37530523-37560548 ~-30K 15871(RAB5C)(-)Link out to UCSC