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0EYA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEYA2
DescriptionEyes absent homolog 2 (ec 3.1.3.48).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0001747 eye development (sensu Mammalia) (TAS)
0007501 mesodermal cell fate specification (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This group of hydrolase enzymes is structurally different from the alpha/beta hydrolase family (abhydrolase). This group includes L-2-haloacid dehalogenase.poxide hydrolases and phosphatases. The structure consists of two domains. One is an inserted four helix bundle.hich is the least well conserved region of the alignment.etween residues 16 and 96 of HAD1_PSESP. The rest of the fold is composed of the core alpha/beta domain.
  IPR005834:Haloacid dehalogenase-like hydrolase
The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye.uscle.idney and ear. Eyes absent is a nuclear transcription factor.cting through interaction withhomeodomain-containing Sine oculis (also known as Six) proteins. Eyes absent is also a protein tyrosine phosphatase It does not resemble theclassical tyrosine phosphatases that use cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. Rather.yes absent is the prototype fora class of protein tyrosine phosphatases that use a nucleophilic aspartic acid in a metal-dependent reaction. Furthermore.he phosphatase activity of Eyes absentcontributes to its ability to induce eye formation in drosophila. Thus.yes absent belongs to thephosphatase subgroup of the haloacid dehalogenase (HAD) superfamily and appears to act as a nuclear transcriptional coactivator with intrinsic phosphatase activity.The Eyes absent proteins contain a divergent 200300-residue.mino-terminal region and a conserved carboxy-terminal domain of 271274 residues (EYA domain).hich iscritical for activity and believed to participate in proteinprotein interactions
  IPR006545:EYA
IPR005834:Hydrolase 
Evalue:-13.180456161499 
Location:268-523
SequencesProtein: EYA2_HUMAN (538 aa)
mRNA: NM_172111 NM_172113
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01104
  Level 3 annotation:
    protein-tyrosine phosphatase
  Level 2 annotation:
    Signal transduction mechanisms
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 135 residues, 45040280-45040682Exon2: 41 residues, 45052046-45052165Exon3: 17 residues, 45063473-45063519Exon4: 49 residues, 45066987-45067130Exon5: 41 residues, 45078226-45078343Exon6: 24 residues, 45134230-45134298Exon7: 61 residues, 45136203-45136381Exon8: 49 residues, 45151284-45151427Exon9: 30 residues, 45159130-45159214Exon10: 32 residues, 45205104-45205194Exon11: 21 residues, 45231193-45231252Exon12: 55 residues, 45234761-45234922Exon13: 40 residues, 45241852-45241967Exon14: 42 residues, 45242869-45242991Exon15: 35 residues, 45245345-45245446Exon16: 265 residues, 45250107-45250897Exon17: 2 residues, -Jump to EYA2_HUMANExon1: 50 residues, 45041528-45041676Exon2: 41 residues, 45052046-45052165Exon3: 17 residues, 45063473-45063519Exon4: 49 residues, 45066987-45067130Exon5: 41 residues, 45078226-45078343Exon6: 24 residues, 45134230-45134298Exon7: 61 residues, 45136203-45136381Exon8: 49 residues, 45151284-45151427Exon9: 30 residues, 45159130-45159214Exon10: 32 residues, 45205104-45205194Exon11: 21 residues, 45231193-45231252Exon12: 55 residues, 45234761-45234922Exon13: 40 residues, 45241852-45241967Exon14: 42 residues, 45242869-45242991Exon15: 35 residues, 45245345-45245446Exon16: 265 residues, 45250107-45250897Exon17: 2 residues, -Jump to EYA2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4526 45271787-45418881 ~-147K 23268(PRKCBP1)(-)Loci: 3263 45564052-45719019 ~-155K 23291(NCOA3)(+)Loci: 3262 45040280-45250897 ~-211K 23265(EYA2)(+)Link out to UCSC