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0EXOC7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEXOC7
DescriptionExocyst complex component 7 (exocyst complex component exo70).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains assigned to SynO:
Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif . These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs.s based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways.nd contribute to the specificity of intracellular membrane fusion processes.The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE).AMP-2 (v-SNARE).nd the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a.hich is required for neurotransmitter release.yntaxin 6.hich is found in endosomal transport vesicles .east Sso1p .nd Vam3p. yeast syntaxin essential for vacuolar fusion . The SNARE motifs in these proteins share structural similarity.espite having a low level of sequence similarity.
  IPR010989:t-snare
InterPro domains unassigned to SynO:
The Exo70 protein forms one subunit of the exocyst complex. First discovered in Saccharomyces cerevisiae .xo70 and other exocyst proteins have been observed in several other eukaryotes.ncluding humans. In S. cerevisiae.heexocyst complex is involved in the late stages of exocytosis.nd is localized at the tip of the bud.he major site of exocytosis in yeast . Exo70 interacts with the Rho3 GTPase . This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud) . In humans.he functions of Exo70 and the exocyst complex are less well characterized: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis .
  IPR004140:Exo70 exocyst complex subunit
IPR004140:Exo70 
Evalue:-248.283996582031 
Location:55-732
SequencesProtein: EXOC7_HUMAN (735 aa)
mRNA: BC018466 NM_001013839
Local Annotation
Synapse Ontology
Fusion of intracellular membrane-bound vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
sdb:0049 synaptic vesicle fusion  (Evidence:domains)
priming for exocytosis prepares the calcium-dependent release and may involve partial fusion process. The vesicles are primed and become responsive to calcium.
sdb:0120 priming  (Evidence:domains)
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:domains)
?
sdb:0328 transmitters release and endocytosis  (Evidence:domains)
KO assignmentK07195
  Level 3 annotation:
    exocyst complex component 7
  Level 2 annotation:
    Insulin signaling pathway
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 916 residues, 71588681-71591426Exon2: 46 residues, 71591681-71591815Exon3: 16 residues, 71591923-71591965Exon4: 23 residues, 71592192-71592256Exon5: 34 residues, 71592989-71593085Exon6: 42 residues, 71593352-71593473Exon7: 24 residues, 71593755-71593821Exon8: 24 residues, 71595329-71595396Exon9: 23 residues, 71595735-71595798Exon10: 35 residues, 71596139-71596238Exon11: 53 residues, 71596446-71596599Exon12: 50 residues, 71596850-71596996Exon13: 33 residues, 71598818-71598911Exon14: 58 residues, 71602089-71602257Exon15: 76 residues, 71605471-71605694Exon16: 37 residues, 71608946-71609052Exon17: 63 residues, 71609354-71609539Exon18: 24 residues, 71611036-71611102Exon19: 49 residues, 71611308-71611451Exon20: 2 residues, -Jump to EXOC7_HUMANExon1: 454 residues, 71590067-71591426Exon2: 46 residues, 71591681-71591815Exon3: 16 residues, 71591923-71591965Exon4: 23 residues, 71592192-71592256Exon5: 34 residues, 71592989-71593085Exon6: 42 residues, 71593352-71593473Exon7: 24 residues, 71593755-71593821Exon8: 24 residues, 71595329-71595396Exon9: 23 residues, 71595735-71595798Exon10: 35 residues, 71596139-71596238Exon11: 53 residues, 71596446-71596599Exon12: 50 residues, 71596850-71596996Exon13: 53 residues, 71598004-71598157Exon14: 33 residues, 71598818-71598911Exon15: 58 residues, 71602089-71602257Exon16: 76 residues, 71605471-71605694Exon17: 37 residues, 71608946-71609052Exon18: 63 residues, 71609354-71609539Exon19: 24 residues, 71611036-71611102Exon20: 23 residues, 71611308-71611371Exon21: 2 residues, -Jump to EXOC7_HUMAN  
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Loci Cluster (Details)Loci: 3038 70178864-70255068 ~-76K 16552(+)Loci: 3039 70256378-70277089 ~-21K 16559(SLC9A3R1)(+)Loci: 4310 70349762-70367602 ~-18K 16565(GRIN2C)(-)Loci: 4311 70370220-70380710 ~-10K 16567(FDXR)(-)Loci: 4312 70546549-70554669 ~-8K 16577(ATP5H)(-)Loci: 4313 70637918-70639472 ~-2K 16582(NT5C)(-)Loci: 4314 70744289-70769272 ~-25K 16589(GGA3)(-)Loci: 4315 70780668-70797109 ~-16K 16594(SLC25A19)(-)Loci: 4316 71265612-71272875 ~-7K 16620(GALK1)(-)Loci: 4317 71514521-71534972 ~-20K 16639(EVPL)(-)Loci: 4318 71546785-71580202 ~-33K 16642(SRP68)(-)Loci: 3040 71582486-71585168 ~-3K 16644(GALR2)(+)Loci: 3041 71586857-71590480 ~-4K 16645(+)Loci: 4319 71588681-71611451 ~-23K 16647(EXOC7)(-)Loci: 3037 69833964-69859062 ~-25K 16537(+)Link out to UCSC