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0EVPL_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEVPL
DescriptionEnvoplakin (210 kda paraneoplastic pemphigus antigen) (p210) (210 kda cornified envelope precursor protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0009506 plasmodesma (TAS)
0005198 structural molecule activity (TAS)
0008544 epidermis development (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Spectrin repeats are found in several proteins involved incytoskeletal structure. These include spectrin.lpha-actininand dystrophin. The spectrin repeat forms athree helix bundle. The second helix is interrupted by prolinein some sequences. The repeats are defined by a characteristictryptophan (W) residue at position 17 in helix A and a leucine(L) at 2 residues from the carboxyl end of helix C.
  IPR002017:Spectrin repeat
Plectin may have a role in cross-linking intermediate filaments.n inter-linking intermediate filaments with microtubules and microfilaments and in anchoring intermediate filaments to the plasma and nuclear membranes. Plectin is recruited into hemidesmosomes multiprotein complexes that facilitate adhesion of epithelia to the basement membrane.hereby providing linkage between the intracellular keratin filaments to the laminins of the extracellular matrix. Plectin binds to hemidesmosomes through association of its actin-binding domain with the first pair of fibronectin type III repeats and a small part of the connecting segment of the integrin-beta4 subunit.he latter (integrin-alpha6.eta4) acting as a receptor for the extracellular matrix component laminin-5.The plectin repeat is also seen in the cell adhesion junction plaque proteins.esmoplakin.nvoplakin.nd bullous pemphigoid antigen. The domains in plakins show considerable sequence homology. The N-terminus consists of a plakin domain containing a number of subdomains with high alpha-helical content.hile the central coiled-coil domain is composed of heptad repeats involved in the dimerisation of plakin.nd the C-terminus contains one or more homologous repeat sequences referred to plectin repeats . This entry represents the plectin repeats found in the C-terminus of plakin proteins.
  IPR001101:Plectin repeat
IPR001101:Plectin 
Evalue:-17.2518119812012 
Location:1856-1900IPR001101:Plectin 
Evalue:-13.0915145874023 
Location:1932-1976IPR001101:PLEC 
Evalue:-6.1249387366083 
Location:1818-1855IPR002017:SPEC 
Evalue:-4.82390874094432 
Location:229-330IPR001101:PLEC 
Evalue:-4.76955107862173 
Location:1678-1713IPR001101:PLEC 
Evalue:-1.92081875395238 
Location:1185-1226IPR001101:PLEC 
Evalue:1.41497334797082 
Location:1729-1763
SequencesProtein: EVPL_HUMAN (2033 aa)
mRNA: NM_001988
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords)
A dendritic spine is a mushroom-shaped bud that protrudes from a dendrite and forms one half of a synapse, especially in synapses of the cortex. The dendrites of cortical neurons typically are densely covered with such spines, which enable single cells to receive input from thousands of others.
sdb:0134 dendritic spine  (Evidence:keywords)
cytoskeleton filaments is one kind of structural components to maintain synapse morphology and bear the related function which is connected with the synaptic morphology.
sdb:0280 cytoskeletal filaments  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1233 residues, 71514521-71518219Exon2: 33 residues, 71519251-71519344Exon3: 39 residues, 71519447-71519558Exon4: 30 residues, 71519681-71519765Exon5: 52 residues, 71522101-71522252Exon6: 66 residues, 71522591-71522785Exon7: 48 residues, 71522902-71523041Exon8: 61 residues, 71523125-71523304Exon9: 59 residues, 71525414-71525587Exon10: 34 residues, 71525836-71525934Exon11: 53 residues, 71526121-71526276Exon12: 51 residues, 71526589-71526736Exon13: 44 residues, 71527203-71527329Exon14: 34 residues, 71529143-71529239Exon15: 38 residues, 71529349-71529457Exon16: 56 residues, 71529542-71529704Exon17: 15 residues, 71529864-71529903Exon18: 44 residues, 71530088-71530214Exon19: 44 residues, 71530967-71531094Exon20: 53 residues, 71531175-71531330Exon21: 35 residues, 71531696-71531796Exon22: 67 residues, 71534776-71534972Exon23: 2 residues, -Jump to EVPL_HUMAN  
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Loci Cluster (Details)Loci: 3038 70178864-70255068 ~-76K 16552(+)Loci: 3039 70256378-70277089 ~-21K 16559(SLC9A3R1)(+)Loci: 4310 70349762-70367602 ~-18K 16565(GRIN2C)(-)Loci: 4311 70370220-70380710 ~-10K 16567(FDXR)(-)Loci: 4312 70546549-70554669 ~-8K 16577(ATP5H)(-)Loci: 4313 70637918-70639472 ~-2K 16582(NT5C)(-)Loci: 4314 70744289-70769272 ~-25K 16589(GGA3)(-)Loci: 4315 70780668-70797109 ~-16K 16594(SLC25A19)(-)Loci: 4316 71265612-71272875 ~-7K 16620(GALK1)(-)Loci: 4317 71514521-71534972 ~-20K 16639(EVPL)(-)Loci: 4318 71546785-71580202 ~-33K 16642(SRP68)(-)Loci: 3040 71582486-71585168 ~-3K 16644(GALR2)(+)Loci: 3041 71586857-71590480 ~-4K 16645(+)Loci: 4319 71588681-71611451 ~-23K 16647(EXOC7)(-)Loci: 3037 69833964-69859062 ~-25K 16537(+)Link out to UCSC