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0ETFB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameETFB
DescriptionElectron transfer flavoprotein beta-subunit (beta-etf).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005759 mitochondrial matrix (TAS)
0009055 electron carrier activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The electron transfer flavoprotein (ETF) .erves as a specific electronacceptor for various mitochondrial dehydrogenases. ETF transfers electrons tothe main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is anheterodimer that consist of an alpha and a beta subunit and which bind onemolecule of FAD per dimer. A similar system also exists in some bacteria.The beta subunit of ETF is a protein of about 28 Kd which is structurallyrelated to the bacterial nitrogen fixation protein fixA which could play arole in a redox process and feed electrons to ferredoxin.The beta subunit protein is distantly related to and forms aheterodimer with the alpha subunit .
  IPR000049:Electron transfer flavoprotein beta-subunit
Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases.ransferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive.housekeeping" ETFs.ainly involved in the oxidation of fatty acids (Group I).nd ETFs produced by some prokaryotes under specific growth conditions.eceiving electrons only from the oxidation of specific substrates (Group II) . ETFs are heterodimeric proteins composed of an alpha and beta subunit.nd contain an FAD cofactor and AMP . ETF consists of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit.espectively.hile domain III is formed by the beta subunit. Domains I and III share an almost identical alpha-beta-alpha sandwich fold.hile domain II forms an alpha-beta-alpha sandwhich similar to that of bacterial flavodoxins. FAD is bound in a cleft between domains II and III.hile domain III binds the AMP molecule. Interactions between domains I and III stabilise the protein.orming a shallow bowl where domain II resides.This entry represents the beta subunit (domain III) of both Group I and Group II ETFs.
  IPR012255:Electron transfer flavoprotein, beta subunit
IPR000049:ETF 
Evalue:-79.3872146606445 
Location:25-217
SequencesProtein: ETFB_HUMAN (255 aa)
mRNA: NM_001985
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK03521
  Level 3 annotation:
    electron transfer flavoprotein beta subunit
  Level 2 annotation:
    Oxidative phosphorylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 76 residues, 56540220-56540447Exon2: 55 residues, 56541965-56542124Exon3: 23 residues, 56545394-56545457Exon4: 55 residues, 56548197-56548356Exon5: 55 residues, 56549215-56549374Exon6: 51 residues, 56561335-56561484Exon7: 2 residues, -Jump to ETFB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4415 56940838-56946962 ~-6K 19471(FPR1)(-)Loci: 3134 57385045-57421482 ~-36K 19494(PPP2R1A)(+)Loci: 4414 56540220-56561484 ~-21K 19449(ETFB)(-)Link out to UCSC