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0EST1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameCES1
DescriptionLiver carboxylesterase 1 precursor (ec 3.1.1.1) (acyl coenzyme a:cholesterol acyltransferase) (acat) (monocyte/macrophage serine esterase) (hmse) (serine esterase 1) (brain carboxylesterase hbr1) (triacylglycerol hydrolase) (tgh) (egasyn).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004759 serine esterase activity (TAS)
0008152 metabolism (TAS)
0009636 response to toxin (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Higher eukaryotes have many distinct esterases. Among the different types arethose which act on carboxylic esters (). Carboxyl-esterases havebeen classified into three categories (A. and C) on the basis ofdifferential patterns of inhibition by organophosphates. The sequence of anumber of type-B carboxylesterases indicates that the majority are evolutionary related. As is the case for lipases and serine proteases.he catalytic apparatus ofesterases involves three residues (catalytic triad): a serine. glutamate oraspartate and a histidine.
  IPR002018:Carboxylesterase, type B
IPR002018:COesterase 
Evalue:-212.142669677734 
Location:1-547
SequencesProtein: EST1_HUMAN (567 aa)
mRNA: NM_001025194 NM_001025195 NM_001266 S73751
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK01044
  Level 3 annotation:
    carboxylesterase
  Level 2 annotation:
    Alkaloid biosynthesis II
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 127 residues, 54394266-54394645Exon2: 26 residues, 54394941-54395014Exon3: 46 residues, 54397745-54397877Exon4: 51 residues, 54401929-54402077Exon5: 29 residues, 54402339-54402420Exon6: 49 residues, 54404315-54404456Exon7: 15 residues, 54408336-54408375Exon8: 37 residues, 54410947-54411052Exon9: 38 residues, 54411784-54411892Exon10: 53 residues, 54412780-54412934Exon11: 46 residues, 54414962-54415096Exon12: 50 residues, 54417563-54417708Exon13: 70 residues, 54420179-54420384Exon14: 55 residues, 54424416-54424576Exon15: 2 residues, -Jump to EST1_HUMANExon1: 127 residues, 54394266-54394645Exon2: 26 residues, 54394941-54395014Exon3: 46 residues, 54397745-54397877Exon4: 51 residues, 54401929-54402077Exon5: 30 residues, 54402339-54402423Exon6: 49 residues, 54404315-54404456Exon7: 15 residues, 54408336-54408375Exon8: 37 residues, 54410947-54411052Exon9: 38 residues, 54411784-54411892Exon10: 53 residues, 54412780-54412934Exon11: 46 residues, 54414962-54415096Exon12: 50 residues, 54417563-54417708Exon13: 70 residues, 54420179-54420384Exon14: 55 residues, 54424416-54424576Exon15: 2 residues, -Jump to EST1_HUMANExon1: 127 residues, 54394266-54394645Exon2: 26 residues, 54394941-54395014Exon3: 46 residues, 54397745-54397877Exon4: 51 residues, 54401929-54402077Exon5: 30 residues, 54402339-54402423Exon6: 49 residues, 54404315-54404456Exon7: 15 residues, 54408336-54408375Exon8: 37 residues, 54410947-54411052Exon9: 38 residues, 54411784-54411892Exon10: 53 residues, 54412780-54412934Exon11: 46 residues, 54414962-54415096Exon12: 50 residues, 54417563-54417708Exon13: 71 residues, 54420179-54420387Exon14: 55 residues, 54424416-54424576Exon15: 2 residues, -Jump to EST1_HUMANExon1: 73 residues, 54394428-54394645Exon2: 26 residues, 54394941-54395014Exon3: 46 residues, 54397745-54397877Exon4: 51 residues, 54401929-54402077Exon5: 30 residues, 54402339-54402423Exon6: 49 residues, 54404315-54404456Exon7: 15 residues, 54408336-54408375Exon8: 37 residues, 54410947-54411052Exon9: 38 residues, 54411784-54411892Exon10: 53 residues, 54412780-54412934Exon11: 46 residues, 54414962-54415096Exon12: 50 residues, 54417563-54417708Exon13: 71 residues, 54420179-54420386Exon14: 27 residues, 54424415-54424490Exon15: 2 residues, -Jump to EST1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4225 54394266-54424576 ~-30K 14117(CES1)(-)Loci: 2940 54248056-54295199 ~-47K 14116(SLC6A2)(+)Link out to UCSC