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0EST1A_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionTelomerase-binding protein est1a (ever shorter telomeres 1a) (telomerase subunit est1a) (est1-like protein a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
PINc describes a large group of domains which are predicted to play a role in nucleotide-binding.otentially being found in RNases. PINc domains in nematode SMG-5 and yeast NMD4p are predicted to be involved in the posttranscriptional gene silencing pathway known as RNA interference (RNAi). In an early step in RNAi.he initiating dsRNA is cleaved into small interfering RNAs (siRNAs).1–23 nucleotides long.y the enzyme Dicer. After processing by Dicer.iRNAs associate with a multicomponent complex called the RNA-induced silencing complex that recognizes and cleaves the cognate message .
  IPR006596:Nucleotide binding protein, PINc
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the tetratricopeptide repeat (TPR) (found in kinesin light chains.NAP regulatory proteins.lathrin heavy chains and bacterial aspartyl-phosphate phosphatases).nd the pentatricopeptide repeat (PPR) (RNA-processing proteins). The TRP is likely to be an ancient repeat.ince it is found in eukaryotes.acteria and archaea.hereas the PPR repeat is found predominantly in higher plants. The superhelix formed from these repeats can bind ligands at a number of different regions.nd has the ability to acquire multiple functional roles .
  IPR011990:Tetratricopeptide-like helical
SequencesProtein: EST1A_HUMAN (1419 aa)
mRNA: NM_017575
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 594 residues, 1909887-1911666Exon2: 29 residues, 1915116-1915198Exon3: 72 residues, 1915511-1915723Exon4: 53 residues, 1918821-1918975Exon5: 51 residues, 1931853-1932000Exon6: 61 residues, 1935768-1935945Exon7: 69 residues, 2022701-2022903Exon8: 58 residues, 2036706-2036875Exon9: 41 residues, 2038442-2038559Exon10: 50 residues, 2086535-2086681Exon11: 22 residues, 2094701-2094763Exon12: 73 residues, 2132690-2132903Exon13: 39 residues, 2133668-2133779Exon14: 28 residues, 2142595-2142674Exon15: 37 residues, 2142914-2143021Exon16: 39 residues, 2147286-2147397Exon17: 66 residues, 2147906-2148099Exon18: 588 residues, 2148949-2150708Exon19: 33 residues, 2153676-2153769Exon20: 2 residues, -Jump to EST1A_HUMAN  
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