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0ESPL1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameESPL1
DescriptionSeparin (ec 3.4.22.49) (separase) (caspase-like protein espl1) (extra spindle poles-like 1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005813 centrosome (IEP)
0003824 catalytic activity (NAS)
0008234 cysteine-type peptidase activity (NAS)
0005515 protein binding (IPI)
0006915 apoptosis (TAS)
0000910 cytokinesis (NAS)
0040001 establishment of mitotic spindle localization (NAS)
0000070 mitotic sister chromatid segregation (IMP)
0045875 negative regulation of sister chromatid coh... (NAS)
0045842 positive regulation of mitotic metaphase/an... (NAS)
0000074 regulation of progression through cell cycle (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Peptidases are grouped into clans and families. Clans are groups of families for which there is evidence of common ancestry. Families are grouped by their catalytic type.he first character representing the catalytic type: A.spartic; C.ysteine; G.lutamic acid; M.etallo; S.erine; T.hreonine; and U.nknown. A clan that contains families of more than one type is described as being of type P. The serine.hreonine and cysteine peptidases utilise the catalytic part of an amino acid as a nucleophile and form an acyl intermediate - these peptidases can also readily act as transferases. In the case of aspartic.lutamic and metallopeptidases.he nucleophile is an activated water molecule. Cysteine peptidases have characteristic molecular topologies.hich can be seen not only in their three-dimensional structures.ut commonly also in the two-dimensional structures. The peptidase domain is responsible for peptide bond hydrolysis; in Merops this is termed the peptidase unit. These are peptidases in which the nucleophile is the sulphydryl group of a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related).nd further sub-divided into families.n the basis of the architecture of their catalytic dyad or triad : Clan CA contains the families of papain (C1).alpain (C2).treptopain (C10) and the ubiquitin-specific peptidases (C12.19).s well as many families of viral cysteine endopeptidases. Clan CD contains the families of clostripain (C11).ingipain R (C25).egumain (C13).aspase-1 (C14) and separin (C50). These enzymes have specificities dominated by the interactions of the S1 subsite. Clan CE contains the families of adenain (C5) from adenoviruses.he eukaryotic Ulp1 protease (C48) and the bacterial YopJ proteases (C55). Clan CF contains only pyroglutamyl peptidase I (C15). Clan PA contains the picornains (C3).hich have probably evolved from serine peptidases and which form the majority of enzymes in this clan. Clans PB and CH contain the autolytic cysteine peptidases. This group of cysteine peptidases belong to MEROPS peptidase family C50 (separase family.lan CD). The active site residues for members of this family and family C14 occur in the same order in the sequence: H..The separases are caspase-like proteases.hich plays a central role in the chromosome segregation. In yeast they cleave the rad21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle.eparase is inactivated by the securin/cut2 protein.hich probably covers its active site.
  IPR005314:Peptidase C50, separase
IPR005314:Peptidase_C50 
Evalue:-159.148742675781 
Location:1708-2069
SequencesProtein: ESPL1_HUMAN (2120 aa)
mRNA: NM_012291
Local Annotation
Synapse Ontology
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK02365
  Level 3 annotation:
    separase
  Level 2 annotation:
    Cell cycle
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 51948817-51948898Exon2: 356 residues, 51949074-51950136Exon3: 37 residues, 51950428-51950533Exon4: 42 residues, 51950728-51950849Exon5: 47 residues, 51952771-51952908Exon6: 66 residues, 51954867-51955061Exon7: 82 residues, 51956670-51956910Exon8: 50 residues, 51957133-51957278Exon9: 48 residues, 51957520-51957659Exon10: 48 residues, 51957871-51958011Exon11: 47 residues, 51959782-51959917Exon12: 42 residues, 51961557-51961677Exon13: 59 residues, 51962314-51962486Exon14: 45 residues, 51963179-51963308Exon15: 54 residues, 51963432-51963589Exon16: 38 residues, 51964108-51964218Exon17: 331 residues, 51965974-51966963Exon18: 125 residues, 51968022-51968392Exon19: 56 residues, 51968588-51968750Exon20: 73 residues, 51969140-51969354Exon21: 65 residues, 51969454-51969645Exon22: 44 residues, 51970135-51970263Exon23: 43 residues, 51970397-51970520Exon24: 54 residues, 51970891-51971047Exon25: 59 residues, 51971740-51971911Exon26: 37 residues, 51972034-51972139Exon27: 40 residues, 51972328-51972444Exon28: 30 residues, 51972624-51972708Exon29: 57 residues, 51972856-51973021Exon30: 126 residues, 51973323-51973697Exon31: 2 residues, -Jump to ESPL1_HUMAN  
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Loci Cluster (Details)Loci: 2755 50587468-50601120 ~-14K 8882(ACVRL1)(+)Loci: 2756 50631752-50677126 ~-45K 8883(ACVR1B)(+)Loci: 2757 50687014-50695938 ~-9K 8886(GRASP)(+)Loci: 4034 50965965-50971566 ~-6K 8896(KRTHB1)(-)Loci: 2758 50981917-50988684 ~-7K 8897(KRTHB6)(+)Loci: 4035 50994358-51001438 ~-7K 8898(KRTHB3)(-)Loci: 4036 51040058-51047576 ~-8K 8899(KRTHB5)(-)Loci: 4037 51057862-51065684 ~-8K 8900(KRTHB4)(-)Loci: 4038 51104120-51114373 ~-10K 8902(-)Loci: 4039 51148861-51153824 ~-5K 8903(KRT6D)(-)Loci: 4040 51167243-51173287 ~-6K 8904(KRT6A)(-)Loci: 4041 51194627-51200510 ~-6K 8905(KRT5)(-)Loci: 4042 51265639-51281559 ~-16K 8909(-)Loci: 4043 51448205-51457372 ~-9K 8917(KRT2P)(-)Loci: 4044 51486600-51494602 ~-8K 8920(KRT4)(-)Loci: 4045 51577237-51585127 ~-8K 8924(KRT8)(-)Loci: 2759 51629109-51632951 ~-4K 8926(KRT18)(+)Loci: 2761 51948817-51973697 ~-25K 8948(ESPL1)(+)Loci: 4046 52160546-52179538 ~-19K 8970(MAP3K12)(-)Loci: 4047 52186740-52187689 ~-1K 8973(NPFF)(-)Loci: 4048 52345211-52356779 ~-12K 8978(ATP5G2)(-)Loci: 2754 50271286-50488365 ~-217K 8878(SCN8A)(+)Link out to UCSC