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0ERG24_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTM7SF2
DescriptionDelta(14)-sterol reductase (ec 1.3.1.70) (c-14 sterol reductase) (sterol c14-reductase) (delta14-sr) (transmembrane 7 superfamily member 2) (another new gene 1 protein) (putative sterol reductase sr- 1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (TAS)
0005887 integral to plasma membrane (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The two fungal enzymes.-14 sterol reductase (gene ERG24 in budding yeast and erg3 inNeurospora Crassa) and C-24(28) sterol reductase (gene ERG4 in budding yeast and sts1in fission yeast).re involved in ergosterol biosynthesis. They act by reducingdouble bonds in precursors of ergosterol .These proteins are highly hydrophobic and seem to contain seven or eight transmembraneregions. Chicken lamin B receptor that is thought to anchor the lamina to the innernuclear membrane belongs to this family.
  IPR001171:ERG4/ERG24 ergosterol biosynthesis protein
IPR001171:ERG4_ERG24 
Evalue:-170.193817138672 
Location:7-418
SequencesProtein: ERG24_HUMAN (418 aa)
mRNA: AF096304 BC009052
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00222
  Level 3 annotation:
    D14-sterol reductase
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 61 residues, 64635935-64636115Exon2: 67 residues, 64636562-64636759Exon3: 20 residues, 64636858-64636913Exon4: 67 residues, 64637267-64637462Exon5: 36 residues, 64637538-64637642Exon6: 42 residues, 64638760-64638880Exon7: 58 residues, 64638960-64639129Exon8: 29 residues, 64639361-64639442Exon9: 43 residues, 64639523-64639646Exon10: 113 residues, 64639940-64640274Exon11: 2 residues, -Jump to ERG24_HUMANExon1: 60 residues, 64635937-64636115Exon2: 67 residues, 64636562-64636759Exon3: 20 residues, 64636858-64636913Exon4: 67 residues, 64637267-64637462Exon5: 36 residues, 64637538-64637642Exon6: 42 residues, 64638760-64638880Exon7: 58 residues, 64638960-64639129Exon8: 29 residues, 64639361-64639442Exon9: 43 residues, 64639523-64639646Exon10: 54 residues, 64639940-64640097Exon11: 23 residues, 64640210-64640274Exon12: 2 residues, -Jump to ERG24_HUMAN  
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Loci Cluster (Details)Loci: 2672 63498654-63500590 ~-2K 6992(COX8A)(+)Loci: 2673 63758841-63762834 ~-4K 7008(VEGFB)(+)Loci: 2674 63775570-63791969 ~-16K 7011(PLCB3)(+)Loci: 2675 63883200-63896262 ~-13K 7031(RPS6KA4)(+)Loci: 3958 64130223-64247236 ~-117K 7042(NRXN2)(-)Loci: 3959 64376783-64402767 ~-26K 7059(EHD1)(-)Loci: 2676 64551485-64564618 ~-13K 7071(SNX15)(+)Loci: 2677 64635935-64640274 ~-4K 7081(TM7SF2)(+)Loci: 2678 64705918-64736052 ~-30K 7088(CAPN1)(+)Loci: 2679 65049159-65062750 ~-14K 7102(+)Loci: 3960 65121802-65138296 ~-16K 7115(MAP3K11)(-)Loci: 3961 65407787-65412586 ~-5K 7136(FIBP)(-)Loci: 3962 65416267-65424573 ~-8K 7139(FOSL1)(-)Loci: 2680 65594399-65768789 ~-174K 7153(PACS1)(+)Loci: 2681 65792680-65801537 ~-9K 7155(RAB1B)(+)Loci: 2682 65815916-65820707 ~-5K 7159(+)Loci: 3963 65856117-65860576 ~-4K 7162(RIN1)(-)Loci: 2683 66140672-66151387 ~-11K 7189(RBM14)(+)Loci: 2684 66162753-66170514 ~-8K 7192(RBM4)(+)Loci: 3964 66209298-66245446 ~-36K 7194(SPTBN2)(-)Loci: 3965 66372572-66478456 ~-106K 7198(PC)(-)Loci: 2685 66547466-66574905 ~-27K 7200(SYT12)(+)Loci: 2686 66580896-66596059 ~-15K 7201(RHOD)(+)Loci: 3966 66922227-66925952 ~-4K 7219(PPP1CA)(-)Loci: 2687 66979393-66983261 ~-4K 7229(CABP4)(+)Loci: 2688 67130982-67136581 ~-6K 7239(NDUFV1)(+)Loci: 2689 67554684-67560690 ~-6K 7248(NDUFS8)(+)Loci: 2690 67836710-67973317 ~-137K 7259(LRP5)(+)Loci: 2671 63412650-63433621 ~-21K 6988(MARK2)(+)Link out to UCSC