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0ERF1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameETF1
DescriptionEukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (cl1 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0043022 ribosome binding (TAS)
0003747 translation release factor activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in the release factor eRF1 which terminates protein biosynthesis by recognizing stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase center. The crystal structure of human eRF1 is known . The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1..nd 3 of eRF1 corresponding to the anticodon loop.minoacyl acceptor stem.nd T stem of a tRNA molecule.espectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase center. A conserved groove on domain 1.0 A from the GGQ motif.s proposed to form the codon recognition site . This domain is also found in other proteins for which the precise molecular function is unknown. Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.
  IPR005140:eRF1 domain 1
This domain is found in the release factor eRF1 which terminates protein biosynthesis by recognizing stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase center. The crystal structure of human eRF1 is known . The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1..nd 3 of eRF1 corresponding to the anticodon loop.minoacyl acceptor stem.nd T stem of a tRNA molecule.espectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase center. A conserved groove on domain 1.0 A from the GGQ motif.s proposed to form the codon recognition site . This domain is also found in other proteins which may also be involved in translation termination but this awaits experimental verification.
  IPR005142:eRF1 domain 3
This domain is found in the release factor eRF1 which terminates protein biosynthesis by recognizing stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase center. The crystal structure of human eRF1 is known . The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1..nd 3 of eRF1 corresponding to the anticodon loop.minoacyl acceptor stem.nd T stem of a tRNA molecule.espectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase center. A conserved groove on domain 1.0 A from the GGQ motif.s proposed to form the codon recognition site . This domain is also found in other proteins which may also be involved in translation termination
  IPR005141:eRF1 domain 2
These proteins are translation factors that have been characterized in eukaryotes as the non-GTP-binding subunit of a cytosolic heterodimer that acts as a translation release factor for all three stop codons. Members of this orthologous family are found in Eukarya and Archaea. The name used should be eRF1 for the Archaea and aRF1 for the Eukarya. Alternative names include eRF1.UP45.mnipotent suppressor protein 1.
  IPR004403:Peptide chain release factor eRF/aRF subunit 1
IPR005140:eRF1_1 
Evalue:-72.2924270629883 
Location:6-140IPR005142:eRF1_3 
Evalue:-71.6575775146484 
Location:279-417IPR005141:eRF1_2 
Evalue:-69.5086364746094 
Location:144-276
SequencesProtein: ERF1_HUMAN (436 aa)
mRNA: BC014269 NM_004730
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK03265
  Level 3 annotation:
    peptide chain release factor eRF subunit 1
  Level 2 annotation:
    Translation factors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 764 residues, 137869686-137871975Exon2: 51 residues, 137872256-137872404Exon3: 23 residues, 137874152-137874217Exon4: 54 residues, 137874632-137874788Exon5: 45 residues, 137875062-137875192Exon6: 65 residues, 137876351-137876542Exon7: 48 residues, 137877155-137877294Exon8: 48 residues, 137881148-137881288Exon9: 60 residues, 137882279-137882455Exon10: 103 residues, 137906221-137906524Exon11: 46 residues, 137906684-137906817Exon12: 2 residues, -Jump to ERF1_HUMANExon1: 764 residues, 137869686-137871975Exon2: 51 residues, 137872256-137872404Exon3: 23 residues, 137874152-137874217Exon4: 54 residues, 137874632-137874788Exon5: 45 residues, 137875062-137875192Exon6: 65 residues, 137876351-137876542Exon7: 48 residues, 137877155-137877294Exon8: 48 residues, 137881148-137881288Exon9: 60 residues, 137882279-137882455Exon10: 36 residues, 137906420-137906524Exon11: 41 residues, 137906684-137906802Exon12: 2 residues, -Jump to ERF1_HUMAN  
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Loci Cluster (Details)Loci: 4729 137412871-137542257 ~-129K 29467(-)Loci: 3480 137543247-137551259 ~-8K 29476(KIF20A)(+)Loci: 4730 137869686-137906817 ~-37K 29489(ETF1)(-)Loci: 4731 138236311-138238878 ~-3K 29494(LRRTM2)(-)Loci: 3479 137171360-137173313 ~-2K 29461(+)Link out to UCSC