SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0ERCC5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameERCC5
DescriptionDna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004520 endodeoxyribonuclease activity (TAS)
0006283 transcription-coupled nucleotide-excision r... (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/140367704.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Xeroderma pigmentosum (XP) is a human autosomal recessive disease.haracterized by a high incidence of sunlight-induced skin cancer. Peoples skin cells with this condition are hypersensitive to ultraviolet light.ue to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically heterogeneous of XP.howing anything from slight to extreme dysfunction in DNA excision repair . XP-G can be corrected by a 133 Kd nuclear protein.PGC . XPGC is an acidic protein that confers normal UV resistance in expressing cells . It is a magnesium-dependent.ingle-strand DNA endonuclease that makes structure-specific endonucleolytic incisions in a DNA substrate containing a duplex region and single-stranded arms . XPGC cleaves one strand of the duplex at the border with the single-stranded region .XPG belongs to a family of proteins that includes RAD2 from budding yeast and rad13 from fission yeast.hich are single-stranded DNA endonucleases . mouse and human FEN-1. structure-specific endonuclease; RAD2 from fission yeast and RAD27 from budding yeast; fission yeast exo1. 5-3 double-stranded DNA exonuclease that may act in a pathway that corrects mismatched base pairs; yeast DHS1.nd yeast DIN7. Sequence alignment of this family of proteins reveals that similarities are largely confined to two regions. The first is located at the N-terminal extremity (N-region) and corresponds to the first 95 to 105 amino acids. The second region is internal (I-region) and found towards the C-terminus; it spans about 140 residues and contains a highly conserved core of 27 amino acids that includes a conserved pentapeptide (E-A-[DE]-A-[QS]). It is possible that the conserved acidic residues are involved in the catalytic mechanism of DNA excision repair in XPG. The amino acids linking the N- and I-regions are not conserved.
  IPR006085:XPG N-terminal
Xeroderma pigmentosum (XP) is a human autosomal recessive disease.haracterized by a high incidence of sunlight-induced skin cancer. Peoples skin cells with this condition are hypersensitive to ultraviolet light.ue to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically heterogeneous of XP.howing anything from slight to extreme dysfunction in DNA excision repair . XP-G can be corrected by a 133 Kd nuclear protein.PGC . XPGC is an acidic protein that confers normal UV resistance in expressing cells . It is a magnesium-dependent.ingle-strand DNA endonuclease that makes structure-specific endonucleolytic incisions in a DNA substrate containing a duplex region and single-stranded arms . XPGC cleaves one strand of the duplex at the border with the single-stranded region .XPG belongs to a family of proteins that includes RAD2 from budding yeast and rad13 from fission yeast.hich are single-stranded DNA endonucleases . mouse and human FEN-1. structure-specific endonuclease; RAD2 from fission yeast and RAD27 from budding yeast; fission yeast exo1. 5-3 double-stranded DNA exonuclease that may act in a pathway that corrects mismatched base pairs; yeast DHS1.nd yeast DIN7. Sequence alignment of this family of proteins reveals that similarities are largely confined to two regions. The first is located at the N-terminal extremity (N-region) and corresponds to the first 95 to 105 amino acids. The second region is internal (I-region) and found towards the C-terminus; it spans about 140 residues and contains a highly conserved core of 27 amino acids that includes a conserved pentapeptide (E-A-[DE]-A-[QS]). It is possible that the conserved acidic residues are involved in the catalytic mechanism of DNA excision repair in XPG. The amino acids linking the N- and I-regions are not conserved.
  IPR006086:XPG I
The helix-hairpin-helix (HhH) motif is an around 20 amino acids domain present in prokaryotic and eukaryotic non-sequence-specific DNA binding proteins. The HhH motif is similar to.ut distinct from.he helix-turn-helix (HtH) and the helix-loop-helix (HLH) motifs. All three motifs have two helices (H1 and H2) connected by a short turn. DNA-binding proteins with a HhH structural motif are involved in non-sequence-specific DNA binding that occurs via the formation of hydrogen bonds between protein backbone nitrogens and DNA phosphate groups. These HhH motifs are observed in DNA repair enzymes and in DNA polymerases. By contrast.roteins with a HtH motif bind DNA in a sequence-specific manner through the binding of H2 with the major groove; these proteins are primarily gene regulatory proteins. DNA-binding proteins with the HLH structural motif are transcriptional regulatory proteins and are principally related to a wide array of developmental processes .Examples of proteins that contain a HhH motif include the 5-exonuclease domains of prokaryotic DNA polymerases .he eukaryotic/prokaryotic RAD2 family of 5-3 exonulceases such as T4 RNase H and T5 eukaryotic 5 endonucleases such as FEN-1 (Flap) .nd some viral exonucleases.
  IPR008918:Helix-hairpin-helix motif, class 2
Defects in DNA repair proteins can give rise.n humans.o the autosomalrecessive disorders xeroderma pigmentosum (XP) and Cockaynes syndrome . XP is characterised by a high incidence of sunlight-induced skincancer.he effect of skin-cell hypersensitivity to UV resulting from defects inthe nucleotide excision pathway. Seven XP complementation groups havebeen identified: XP-A to XP-G. XP-G is one of the most rare and phenotypicallyheterogeneous of XP.howing anything from slight to extreme dysfunction in DNAexcision repair .XPGC.n acidic protein that confers normal UV resistance in expressing cells.ancorrect XP-G. It is a magnesium-dependent.ingle-strand DNA endonuclease thatmakes structure-specific endonucleolytic incisions in a DNA substrate containinga duplex region and single-stranded arms. XPGC cleaves one strand of the duplex at theborder with the single-stranded region .
  IPR001044:Xeroderma pigmentosum group G protein
Xeroderma pigmentosum (XP) is a human autosomal recessive disease.haracterized by a high incidence of sunlight-induced skin cancer. Peoples skin cells with this condition are hypersensitive to ultraviolet light.ue to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically heterogeneous of XP.howing anything from slight to extreme dysfunction in DNA excision repair . XP-G can be corrected by a 133 Kd nuclear protein.PGC . XPGC is an acidic protein that confers normal UV resistance in expressing cells . It is a magnesium-dependent.ingle-strand DNA endonuclease that makes structure-specific endonucleolytic incisions in a DNA substrate containing a duplex region and single-stranded arms . XPGC cleaves one strand of the duplex at the border with the single-stranded region .XPG belongs to a family of proteins that includes RAD2 from budding yeast and rad13 from fission yeast.hich are single-stranded DNA endonucleases . mouse and human FEN-1. structure-specific endonuclease; RAD2 from fission yeast and RAD27 from budding yeast; fission yeast exo1. 5-3 double-stranded DNA exonuclease that may act in a pathway that corrects mismatched base pairs; yeast DHS1.nd yeast DIN7. Sequence alignment of this family of proteins reveals that similarities are largely confined to two regions. The first is located at the N-terminal extremity (N-region) and corresponds to the first 95 to 105 amino acids. The second region is internal (I-region) and found towards the C-terminus; it spans about 140 residues and contains a highly conserved core of 27 amino acids that includes a conserved pentapeptide (E-A-[DE]-A-[QS]). It is possible that the conserved acidic residues are involved in the catalytic mechanism of DNA excision repair in XPG. The amino acids linking the N- and I-regions are not conserved.
  IPR006084:DNA repair protein (XPGC)/yeast Rad
IPR006085:XPG_N 
Evalue:-55.6020584106445 
Location:1-98IPR006086:XPG_I 
Evalue:-47.8239097595215 
Location:777-865IPR008918:5_3_exo_C 
Evalue:0 
Location:923-988IPR001044:XRODRMPGMNTG 
Evalue:0 
Location:216-241IPR001044:XRODRMPGMNTG 
Evalue:0 
Location:272-296IPR001044:XRODRMPGMNTG 
Evalue:0 
Location:876-896IPR001044:XRODRMPGMNTG 
Evalue:0 
Location:175-193IPR001044:XRODRMPGMNTG 
Evalue:0 
Location:644-662IPR001044:XRODRMPGMNTG 
Evalue:0 
Location:727-743
SequencesProtein: ERCC5_HUMAN (1186 aa)
mRNA: NM_000123
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 178 residues, 102296174-102296705Exon2: 60 residues, 102302468-102302644Exon3: 40 residues, 102304107-102304223Exon4: 31 residues, 102304638-102304725Exon5: 22 residues, 102306402-102306463Exon6: 50 residues, 102308625-102308769Exon7: 71 residues, 102311857-102312065Exon8: 360 residues, 102312380-102313454Exon9: 83 residues, 102316017-102316262Exon10: 42 residues, 102316612-102316732Exon11: 73 residues, 102316982-102317196Exon12: 50 residues, 102318463-102318608Exon13: 69 residues, 102322548-102322749Exon14: 30 residues, 102323609-102323694Exon15: 231 residues, 102325657-102326346Exon16: 2 residues, -Jump to ERCC5_HUMAN  
Tune and view alternative isoforms