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0ERCC4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameERCC4
DescriptionDna repair endonuclease xpf (ec 3.1.-.-) (dna excision repair protein ercc-4) (dna-repair protein complementing xp-f cell) (xeroderma pigmentosum group f complementing protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004520 endodeoxyribonuclease activity (TAS)
0006289 nucleotide-excision repair (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is predicted to be a nuclease domain.nd is found in DNA repair proteins and proteins involved in recombination events during meiosis in Drosophila melanogaster.
  IPR006166:ERCC4
All proteins in this family.or which functions are known.re components in a multiprotein endonuclease complex.sually made up of Rad1 and Rad10 homologues. This complex is used primarily for nucleotide excision repair but also for some aspects of recombinational repair in some species. Most Archaeal species also have homologues of these genes.ut the function of the Archaeal proteins is not known.o are not included in this family.
  IPR006167:DNA repair protein
In prokaryotes.uvA.uvB.nd RuvC process the universal DNA intermediate of homologous recombination.ermed Holliday junction. The tetrameric DNA helicase RuvA specifically binds to the Holliday junction and facilitates the isomerization of the junction from the stacked folded configuration to the square-planar structure . In the RuvA tetramer.ach subunit consists of three domains..I and III.here I and II form the major core that is responsible for Holliday junction binding and base pair rearrangements of Holliday junction executed at the crossover point.hereas domain III regulates branch migration through direct contact with RuvB. Domain 2 has a SAM (sterile alpha motif)-like alpha bundle fold that occurs as a duplication containing two helix-hairpin-helix (HhH) motifs.The C-terminal domain (CTD) of the excision repair protein UvrC shows structural similarity to RuvA domain 2. The CTD of UvrC is essential for 5 incision in the prokaryotic nucleotide excision repair process.nd acts to mediate structure-specific binding to single-stranded-double-stranded junction DNA .Domain 3 of NAD+-dependent DNA ligase consists of a duplication of two RuvA-like domains (four HhH motifs).nd also contains a zinc-finger subdomain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication.epair and recombination.tilizing either ATP or NAD+ as a cofactor .
  IPR010994:RuvA domain 2-like
IPR006166:ERCC4 
Evalue:-46.3187599182129 
Location:672-752IPR010994:RuvA_2_like 
Evalue:0 
Location:840-894
SequencesProtein: ERCC4_HUMAN (905 aa)
mRNA: U64315
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK01175
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 64 residues, 13921541-13921730Exon2: 62 residues, 13923388-13923569Exon3: 67 residues, 13927918-13928114Exon4: 71 residues, 13929385-13929593Exon5: 62 residues, 13932067-13932248Exon6: 45 residues, 13933514-13933643Exon7: 39 residues, 13935549-13935660Exon8: 201 residues, 13936503-13937101Exon9: 33 residues, 13939123-13939216Exon10: 39 residues, 13946080-13946193Exon11: 291 residues, 13948971-13949840Exon12: 2 residues, -Jump to ERCC4_HUMAN  
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Loci Cluster (Details)Loci: 2926 14072696-14268130 ~-195K 13537(MKL2)(+)Loci: 2925 13921541-13949840 ~-28K 13535(ERCC4)(+)Link out to UCSC