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0ERCC3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameERCC3
DescriptionTfiih basal transcription factor complex helicase xpb subunit (ec 3.6.1.-) (basic transcription factor 2 89 kda subunit) (btf2-p89) (tfiih 89 kda subunit) (dna-repair protein complementing xp-b cells) (xeroderma pigmentosum group b complementing protein) (dna excision repair protein ercc-3).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0005675 transcription factor TFIIH complex (TAS)
0043138 3' to 5' DNA helicase activity (IMP)
0003684 damaged DNA binding (TAS)
0008094 DNA-dependent ATPase activity (IMP)
0005515 protein binding (IPI)
0006281 DNA repair (TAS)
0006265 DNA topological change (IMP)
0006917 induction of apoptosis (IMP)
0006366 transcription from RNA polymerase II promoter (IMP)
0006283 transcription-coupled nucleotide-excision r... (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
This family includes the res subunit of type III restriction enzymes () .
  IPR006935:Type III restriction enzyme, res subunit
Defects in DNA repair proteins can give rise.n humans.o the autosomalrecessive disorders xeroderma pigmentosum (XP) and Cockaynes syndrome . XP is characterised by a highincidence of sunlight-induced skin cancer.he effect of skin-cell hypersensitivityto UV resulting from defects in the nucleotide excision pathway. Seven XP complementationgroups have been identified: XP-A to XP-G. XP group B (XP-B) give rise to both XP andCockayne syndrome . The DNA/RNA helicase domain is also present in this group of proteins.
  IPR001161:Xeroderma pigmentosum group B protein (XP-B)
IPR014001:DEXDc 
Evalue:-17.7212463990472 
Location:312-492IPR001650:Helicase_C 
Evalue:-12.8239088058472 
Location:574-647IPR001161:XRODRMPGMNTB 
Evalue:0 
Location:653-676IPR001161:XRODRMPGMNTB 
Evalue:0 
Location:500-522IPR001161:XRODRMPGMNTB 
Evalue:0 
Location:74-94IPR001161:XRODRMPGMNTB 
Evalue:0 
Location:742-761IPR001161:XRODRMPGMNTB 
Evalue:0 
Location:160-179IPR001161:XRODRMPGMNTB 
Evalue:0 
Location:537-552
SequencesProtein: ERCC3_HUMAN (782 aa)
mRNA: NM_000122
Local Annotation
Synapse Ontology
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords)
KO assignmentK01529
  Level 3 annotation:
    
  Level 2 annotation:
    Starch and sucrose metabolism
    Folate biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 147 residues, 127731335-127731773Exon2: 53 residues, 127733341-127733494Exon3: 41 residues, 127735273-127735392Exon4: 41 residues, 127745381-127745499Exon5: 34 residues, 127746910-127747007Exon6: 69 residues, 127753218-127753421Exon7: 63 residues, 127754492-127754677Exon8: 107 residues, 127760748-127761063Exon9: 70 residues, 127762705-127762910Exon10: 57 residues, 127763382-127763547Exon11: 47 residues, 127763734-127763870Exon12: 18 residues, 127764269-127764319Exon13: 81 residues, 127766655-127766892Exon14: 70 residues, 127767558-127767764Exon15: 43 residues, 127768099-127768222Exon16: 2 residues, -Jump to ERCC3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4463 127731335-127768222 ~-37K 21224(ERCC3)(-)Loci: 4462 127522076-127581334 ~-59K 21214(-)Link out to UCSC