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0EP400_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEP400
DescriptionE1a binding protein p400 (ec 3.6.1.-) (p400 kda swi2/snf2-related protein) (domino homolog) (hdomino) (cag repeat protein 32) (trinucleotide repeat-containing gene 12 protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found in proteins involved in a variety of processes including transcription regulation (e.g..NF2.TH1.rahma.OT1).NA repair (e.g..RCC6.AD16.AD5).NA recombination (e.g..AD54).nd chromatin unwinding (e.g..SWI) as well as a variety of other proteins with little functional information (e.g..odestar.TL1) . SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex.hich utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions.esulting in the increased accessibility of DNA to transcription factors.Proteins that contain this domain appear to be distantly related to theDEAX box helicases .oweverno helicase activity has ever been demonstrated for these proteins.
  IPR000330:SNF2-related
This domain of unknown function is found in helicases and other DNA-binding proteins of eukaryotes . This entry occurs in the same type of proteins as .ut has fewer matches.
  IPR013999:HAS subgroup
This domain of unknown function is found in helicases and other DNA-binding proteins of eukaryotes .
  IPR006562:HSA
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
The retroviral oncogene v-myb.nd its cellular counterpart c-myb.ncode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognize the sequence YAAC(G/T)G . In myb.ne of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding .
  IPR001005:Myb, DNA-binding
Homeodomain proteins are transcription factors that share a related DNA binding homeodomain . The homeodomain was first identified in a number of Drosophila homeotic and segmentation proteins.ut is now known to be well conserved in many other animals.ncluding vertebrates. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha-helices.hich make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions.hich occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. Many proteins contain homeodomains.ncluding Drosophila Engrailed.east mating type proteins.epatocyte nuclear factor 1a and HOX proteins.The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins.ncluding recombinases.yb proteins.ARP response regulators.uman telomeric proteins (hTRF1).aired domain proteins (PAX).east RAP1.entromere-binding proteins CENP-B and ABP-1.ranscriptional regulators (TyrR).raC-type transcriptional activators.nd tetracycline repressor-like proteins (TetR.acR.cdC) .
  IPR009057:Homeodomain-like
Homeodomain proteins are transcription factors that share a related DNA binding homeodomain . The homeodomain was first identified in a number of Drosophila homeotic and segmentation proteins.ut is now known to be well conserved in many other animals.ncluding vertebrates. The domain binds DNA through a helix-turn-helix (HTH) structure. The HTH motif is characterised by two alpha helices.hich make intimate contacts with the DNA and are joined by a short turn. The second helix binds to DNA via a number of hydrogen bonds and hydrophobic interactions.hich occur between specific side chains and the exposed bases and thymine methyl groups within the major groove of the DNA. The first helix helps to stabilise the structure. Many proteins contain homeodomains.ncluding Drosophila Engrailed.east mating type proteins.epatocyte nuclear factor 1a and HOX proteins.The homeodomain motif is very similar in sequence and structure to domains in a wide range of DNA-binding proteins.ncluding recombinases.yb proteins.ARP response regulators.uman telomeric proteins (hTRF1).aired domain proteins (PAX).east RAP1.entromere-binding proteins CENP-B and ABP-1.ranscriptional regulators (TyrR).raC-type transcriptional activators.nd tetracycline repressor-like proteins (TetR.acR.cdC) .
  IPR012287:Homeodomain-related
IPR000330:SNF2_N 
Evalue:-55.5376014709473 
Location:1094-1374IPR013999:HSA 
Evalue:-32.0757207139381 
Location:800-871IPR001650:Helicase_C 
Evalue:-6.56863641738892 
Location:1933-2000IPR001005:SANT 
Evalue:-1.39794000867204 
Location:2364-2431IPR001005:MYB_2 
Evalue:0 
Location:0-0
SequencesProtein: EP400_HUMAN (3160 aa)
mRNA: AY044869 NM_015409
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentK01529
  Level 3 annotation:
    
  Level 2 annotation:
    Starch and sucrose metabolism
    Folate biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 25 residues, 131000460-131000534Exon2: 458 residues, 131011082-131012452Exon3: 34 residues, 131030194-131030291Exon4: 38 residues, 131031986-131032094Exon5: 130 residues, 131032590-131032976Exon6: 100 residues, 131037011-131037305Exon7: 64 residues, 131038202-131038388Exon8: 49 residues, 131040461-131040602Exon9: 28 residues, 131041133-131041212Exon10: 18 residues, 131041904-131041954Exon11: 21 residues, 131042670-131042728Exon12: 32 residues, 131045364-131045454Exon13: 38 residues, 131055574-131055682Exon14: 65 residues, 131056609-131056800Exon15: 61 residues, 131057197-131057375Exon16: 47 residues, 131061995-131062132Exon17: 58 residues, 131063506-131063676Exon18: 60 residues, 131063987-131064162Exon19: 47 residues, 131064274-131064411Exon20: 64 residues, 131068032-131068219Exon21: 57 residues, 131068707-131068874Exon22: 58 residues, 131070546-131070716Exon23: 83 residues, 131071576-131071819Exon24: 57 residues, 131074274-131074439Exon25: 55 residues, 131076143-131076302Exon26: 33 residues, 131077934-131078029Exon27: 92 residues, 131078514-131078786Exon28: 69 residues, 131080198-131080401Exon29: 58 residues, 131080486-131080656Exon30: 67 residues, 131082450-131082647Exon31: 39 residues, 131088179-131088291Exon32: 50 residues, 131088450-131088594Exon33: 55 residues, 131093801-131093960Exon34: 30 residues, 131094142-131094226Exon35: 47 residues, 131094674-131094809Exon36: 17 residues, 131095168-131095213Exon37: 53 residues, 131095297-131095451Exon38: 82 residues, 131095816-131096058Exon39: 60 residues, 131096224-131096398Exon40: 47 residues, 131100820-131100957Exon41: 21 residues, 131101096-131101153Exon42: 28 residues, 131103643-131103722Exon43: 87 residues, 131103840-131104095Exon44: 17 residues, 131105471-131105517Exon45: 38 residues, 131105596-131105706Exon46: 73 residues, 131112607-131112821Exon47: 80 residues, 131112963-131113199Exon48: 75 residues, 131115165-131115384Exon49: 67 residues, 131117271-131117467Exon50: 43 residues, 131117859-131117984Exon51: 51 residues, 131119992-131120139Exon52: 28 residues, 131127013-131127091Exon53: 1021 residues, 131127898-131130957Exon54: 2 residues, -Jump to EP400_HUMANExon1: 458 residues, 131011081-131012452Exon2: 35 residues, 131030191-131030291Exon3: 38 residues, 131031986-131032094Exon4: 130 residues, 131032590-131032976Exon5: 100 residues, 131037011-131037305Exon6: 64 residues, 131038202-131038388Exon7: 49 residues, 131040461-131040602Exon8: 28 residues, 131041133-131041212Exon9: 18 residues, 131041904-131041954Exon10: 21 residues, 131042670-131042728Exon11: 32 residues, 131045364-131045454Exon12: 38 residues, 131055574-131055682Exon13: 65 residues, 131056609-131056800Exon14: 61 residues, 131057197-131057375Exon15: 47 residues, 131061995-131062132Exon16: 58 residues, 131063506-131063676Exon17: 60 residues, 131063987-131064162Exon18: 47 residues, 131064274-131064411Exon19: 64 residues, 131068032-131068219Exon20: 57 residues, 131068707-131068874Exon21: 58 residues, 131070546-131070716Exon22: 83 residues, 131071576-131071819Exon23: 57 residues, 131074274-131074439Exon24: 55 residues, 131076143-131076302Exon25: 33 residues, 131077934-131078029Exon26: 92 residues, 131078514-131078786Exon27: 69 residues, 131080198-131080401Exon28: 58 residues, 131080486-131080656Exon29: 67 residues, 131082450-131082647Exon30: 39 residues, 131088179-131088291Exon31: 50 residues, 131088450-131088594Exon32: 55 residues, 131093801-131093960Exon33: 30 residues, 131094142-131094226Exon34: 47 residues, 131094674-131094809Exon35: 17 residues, 131095168-131095213Exon36: 53 residues, 131095297-131095451Exon37: 82 residues, 131095816-131096058Exon38: 60 residues, 131096224-131096398Exon39: 47 residues, 131100820-131100957Exon40: 21 residues, 131101096-131101153Exon41: 28 residues, 131103643-131103722Exon42: 87 residues, 131103840-131104095Exon43: 17 residues, 131105471-131105517Exon44: 38 residues, 131105596-131105706Exon45: 73 residues, 131112607-131112821Exon46: 80 residues, 131112963-131113199Exon47: 75 residues, 131115165-131115384Exon48: 67 residues, 131117271-131117467Exon49: 43 residues, 131117859-131117984Exon50: 51 residues, 131119992-131120139Exon51: 28 residues, 131127013-131127091Exon52: 295 residues, 131127898-131128777Exon53: 2 residues, -Jump to EP400_HUMAN  
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Loci Cluster (Details)Loci: 2803 130979741-130994355 ~-15K 10034(PUS1)(+)Loci: 2804 131000460-131130957 ~-130K 10036(EP400)(+)Loci: 2802 130945231-130973649 ~-28K 10032(ULK1)(+)Link out to UCSC