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0ENPP7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameENPP7
DescriptionEctonucleotide pyrophosphatase/phosphodiesterase 7 precursor (ec 3.1.4.12) (enpp-7) (alkaline sphingomyelin phosphodiesterase) (intestinal alkaline sphingomyelinase) (alk-smase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005794 Golgi apparatus (IDA)
0016020 membrane (NAS)
0005902 microvillus (IDA)
0004767 sphingomyelin phosphodiesterase activity (IDA)
0008285 negative regulation of cell proliferation (IDA)
0008156 negative regulation of DNA replication (IDA)
0006684 sphingomyelin metabolism (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This family consists of phosphodiesterases.ncluding humanplasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase I/ nucleotide pyrophosphatase (nppase). These enzymes catalyse thecleavage of phosphodiester and phosphosulphate bonds in NAD.eoxynucleotides and nucleotide sugars . Another member of this family isATX an autotaxin.umor cell motility-stimulating protein which exhibits type I phosphodiesterases activity .The alignment encompasses the active site .Also present with in this family is 60 kDa Ca2+-ATPase from Myroides odoratus .
  IPR002591:Type I phosphodiesterase/nucleotide pyrophosphatase
IPR002591:Phosphodiest 
Evalue:-107.431800842285 
Location:31-356
SequencesProtein: ENPP7_HUMAN (458 aa)
mRNA: AK126250 NM_178543
Local Annotation
Synapse Ontology
endosome of the presynaptic compartment. A cellular structure that is involved in the transport of proteins in the neuron after the proteins are endocytosed from the outside to the inside of the cell.
sdb:0088 endosome  (Evidence:keywords)
KO assignmentK01117
  Level 3 annotation:
    sphingomyelin phosphodiesterase
  Level 2 annotation:
    Glycosphingolipid metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 159 residues, 75319275-75319749Exon2: 50 residues, 75321900-75322046Exon3: 211 residues, 75323436-75324063Exon4: 75 residues, 75325434-75325654Exon5: 51 residues, 75326309-75326456Exon6: 143 residues, 75330187-75330612Exon7: 2 residues, -Jump to ENPP7_HUMANExon1: 92 residues, 75319476-75319749Exon2: 50 residues, 75321900-75322046Exon3: 211 residues, 75323436-75324063Exon4: 75 residues, 75325434-75325654Exon5: 51 residues, 75326309-75326456Exon6: 144 residues, 75330187-75330615Exon7: 2 residues, -Jump to ENPP7_HUMAN  
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Loci Cluster (Details)Loci: 4322 75797684-75808719 ~-11K 16775(SGSH)(-)Loci: 3044 75319275-75330615 ~-11K 16762(ENPP7)(+)Link out to UCSC