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0ENC1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameENC1
DescriptionEctoderm-neural cortex-1 protein (enc-1) (p53-induced protein 10) (nuclear matrix protein nrp/b).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (TAS)
0007275 development (TAS)
0007399 neurogenesis (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found associated with and .
  IPR011705:BTB/Kelch-associated
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR013069:BTB/POZ
The BTB (for BR-C.tk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N terminus of a fraction of zinc finger() proteins and in proteins that contain the motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation .The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule .POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT .The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
  IPR000210:BTB
Kelch is a 50-residue motif.amed after the Drosophila mutant in which it was first identified . The motif appears 6 times in Drosophila egg-chamber regulatory protein.nd is also found in mouse protein MIPP and in a number of poxviruses. In addition.elch repeats have been recognised in alpha- and beta-scruin and in galactose oxidase from the fungus Dactylium dendroides . The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded anti-parallel beta-sheet motif that forms the repeat unit in a super-barrel structural fold .The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; neuraminidase hydrolyses sialic acid residues from glycoproteins; and kelch may have a cytoskeletal function.s it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila . Nevertheless.ased on the location of the kelch pattern in the catalytic unit in galactose oxidase.unctionally important residues have been predicted in glyoxal oxidase .
  IPR006652:Kelch repeat
Galactose oxidase () is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehyde . The protein contains an unusual covalent thioether bond between a tyrosine and a cysteine that forms during its maturation . Galactose oxidase is a three-domain protein: the N-terminal domain forms a jelly-roll sandwich.he central domain forms a seven 4-bladed beta-propeller.nd the C-terminal domain has an immunoglobulin-like fold.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011043:Galactose oxidase, central
IPR011705:BACK 
Evalue:-41.6777801513672 
Location:149-251IPR013069:BTB 
Evalue:-39.3872146606445 
Location:36-144IPR006652:Kelch 
Evalue:-12.7695510786217 
Location:389-444IPR006652:Kelch_1 
Evalue:-12.2924299240112 
Location:329-375IPR006652:Kelch_1 
Evalue:-11.4948501586914 
Location:527-572IPR006652:Kelch_1 
Evalue:-6.82390880584717 
Location:481-525IPR000169:THIOL_PROTEASE_HIS 
Evalue:0 
Location:0-0
SequencesProtein: ENC1_HUMAN (589 aa)
mRNA: NM_003633
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 862 residues, 73958990-73961573Exon2: 607 residues, 73966264-73968079Exon3: 130 residues, 73971887-73972273Exon4: 2 residues, -Jump to ENC1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3466 74016766-74052867 ~-36K 29006(HEXB)(+)Loci: 4718 73958990-73972273 ~-13K 29005(ENC1)(-)Link out to UCSC