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0ELF2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameELF2
DescriptionEts-related transcription factor elf-2 (e74-like factor 2) (new ets- related factor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (IC)
0005515 protein binding (IPI)
0016563 transcriptional activator activity (IDA)
0006357 regulation of transcription from RNA polyme... (IDA)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Transcription factors are protein molecules that bind to specific DNAsequences in the genome.esulting in the induction or inhibition of genetranscription . The ets oncogene is such a factor.ossessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain . This domain is rich inpositively-charged and aromatic residues.nd binds to purine-rich segmentsof DNA. The ETS domain has been identified in other transcription factorssuch as PU.1.uman erg.uman elf-1.uman elk-1.A binding protein.nda number of others .It is generally localized at the C-terminus of the protein.ith the exception of ELF-1.LK-1.LK-3.LK-4 and ERF where it is found atthe N-terminus. NMR-analysis of the structure of the Ets domains revealed that it contains three alpha-helixes (13) and four-stranded beta-sheets (14) arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4 forming a winged helixturnhelix (wHTH) topology . The third alpha-helix is responsive to contact to the major groove of the DNA. Different members of the Ets family proteins display distinct DNA binding specificities. The Ets domains and the flanking amino acid sequences of the proteins influence the binding affinity.nd the alteration of a single amino acid in the Ets domain can change its DNA binding specificities.Avian leukemia virus E26 is a replication defective retrovirus that induces amixed erythroid/myeloid leukemia in chickens. E26 virus carries two distinctoncogenes.-myb and v-ets. The ets portion of this oncogene is required forthe induction of erythroblastosis. V-ets and c-ets-1.ts cellular progenitor.ave been shown to be nuclear DNA-binding proteins. Ets-1 differs slightlyfrom v-ets at its carboxy-terminal region. In most species where it has beensequenced.-ets-1 exists in various isoforms generated by alternativesplicing and differential phosphorylation.
  IPR000418:Ets
Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif.here the "wings".r loops.re small beta-sheets. The winged helix motif consists of two wings (W1.2).hree alpha helices (H1.2.3) and three beta-sheets (S1.2.3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 . The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA.hile the wings make different DNA contacts.ften with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions.Many different proteins with diverse biological functions contain a winged helix DNA-binding domain.ncluding transcriptional repressors such as biotin repressor.exA repressor and the arginine repressor ; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation.eat-shock transcription factor.nd the general transcription factors TFIIE and TFIIF . helicases such as RuvB that promotes branch migration at the Holliday junction.nd CDC6 in the pre-replication complex . endonucleases such as FokI and TnsA ; histones; and Mu transposase.here the flexible wing of the enhancer-binding domain is essential for efficient transposition .
  IPR011991:Winged helix repressor DNA-binding
IPR000418:Ets 
Evalue:-51.0915145874023 
Location:207-292
SequencesProtein: ELF2_HUMAN (593 aa)
mRNA: NM_201999
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity.
sdb:0043 positive regulation of short-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 631 residues, 140198320-140200211Exon2: 119 residues, 140200927-140201278Exon3: 66 residues, 140202468-140202661Exon4: 31 residues, 140208287-140208374Exon5: 48 residues, 140212469-140212607Exon6: 40 residues, 140214057-140214171Exon7: 57 residues, 140265767-140265933Exon8: 81 residues, 140278233-140278471Exon9: 15 residues, 140280016-140280056Exon10: 2 residues, -Jump to ELF2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3426 140442125-140531385 ~-89K 28199(NARG1)(+)Loci: 3427 140594410-140616513 ~-22K 28200(RAB33B)(+)Loci: 3428 140806371-140844854 ~-38K 28202(MGST2)(+)Loci: 4690 140198320-140280056 ~-82K 28195(ELF2)(-)Link out to UCSC