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0EFTS_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameTSFM
DescriptionElongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0003711 transcriptional elongation regulator activity (TAS)
0006414 translational elongation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
In prokaryotes elongation factor Ts (EF-Ts) is a component of the elongation cycle of protein biosynthesis. It associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP.t remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome .EF-Ts is also a component of the chloroplast protein biosynthetic machinery and is encoded in the genome of some algal chloroplast . It is also present in mitochondria .
  IPR001816:Elongation factor Ts
UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway.NA excision-repair.nd cell signaling via protein kinases . The human homologue of yeast Rad23A is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of human Rad23A UBA(2) showed that the domain forms a compact three-helix bundle . Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch which may be a common protein-interacting surface present in diverse UBA domains. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin .
  IPR000449:Ubiquitin-associated
Enolase (2-phospho-D-glycerate hydrolase) is an essential glycolytic enzyme that catalyses the interconversion of 2-phosphoglycerate and phosphoenolpyruvate . In vertebrates.here are 3 different.issue-specific isoenzymes.esignated alpha.eta and gamma. Alpha is present in most tissues.eta is localised in muscle tissue.nd gamma is found only in nervous tissue. The functional enzyme exists as a dimer of any 2 isoforms. In immature organs and in adult liver.t is usually an alpha homodimer.n adult skeletal muscle. beta homodimer.nd in adult neurons. gamma homodimer. In developing muscle.t is usually an alpha/beta heterodimer.nd in the developing nervous system.n alpha/gamma heterodimer . The tissue specific forms display minor kinetic differences. Tau-crystallin.ne of the major lens proteins in some fish.eptiles and birds.as been shown to be evolutionary related to enolase.Neuron-specific enolase is released in a variety of neurological diseases.uch as multiple sclerosis and after seizures or acute stroke. Several tumour cells have also been found positive for neuron-specific enolase. Beta-enolase deficiency is associated with glycogenosis type XIII defect.
  IPR000941:Enolase
UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway.NA excision-repair.nd cell signalling via protein kinases . HHR23A.he human homologue of yeast Rad23A is a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The fold of the UBA domain consists of a compact three-helical bundle with a right-handed twist.nd have a conserved hydrophobic surface patch for protein-protein interactions. UBA-like domains can be found in other proteins as well.uch as the TS-N domain in the elongation factor Ts (EF-Ts).hich catalyses the recycling of the GTPase EF-Tu required for the binding of aminoacyl-tRNA top the ribosomal A site ; and the C-terminal domain of TAP/NXF1.hich functions in nuclear export through the interaction of its UBA-like domain with FG nucleoporins .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR009060:UBA-like
IPR001816:EF_TS 
Evalue:-73.4814834594727 
Location:102-317IPR000449:UBA 
Evalue:-7.10237312316894 
Location:45-85IPR000941:Enolase 
Evalue:0 
Location:0-0
SequencesProtein: EFTS_HUMAN (325 aa)
mRNA: BC093068 NM_005726
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
KO assignmentK02357
  Level 3 annotation:
    elongation factor EF-Ts
  Level 2 annotation:
    Translation factors
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 56462825-56462908Exon2: 60 residues, 56463159-56463333Exon3: 45 residues, 56466212-56466341Exon4: 43 residues, 56467089-56467212Exon5: 23 residues, 56472014-56472077Exon6: 31 residues, 56473035-56473123Exon7: 188 residues, 56476226-56476784Exon8: 2 residues, -Jump to EFTS_HUMANExon1: 24 residues, 56462839-56462908Exon2: 60 residues, 56463159-56463333Exon3: 45 residues, 56466212-56466341Exon4: 43 residues, 56467089-56467212Exon5: 31 residues, 56473035-56473123Exon6: 188 residues, 56476226-56476784Exon7: 2 residues, -Jump to EFTS_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 2768 56462825-56476784 ~-14K 9198(TSFM)(+)Loci: 4058 56477709-56496119 ~-18K 9200(AVIL)(-)Loci: 4057 56210360-56227245 ~-17K 9162(DCTN2)(-)Link out to UCSC