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0EDNRA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEDNRA
DescriptionEndothelin-1 receptor precursor (endothelin a receptor) (et-a) (het- ar) (eta-r).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0016020 membrane (NAS)
0001599 endothelin-A receptor activity (NAS)
0004435 phosphoinositide phospholipase C activity (TAS)
0005515 protein binding (ISS)
0007190 adenylate cyclase activation (TAS)
0008283 cell proliferation (NAS)
0007204 elevation of cytosolic calcium ion concentr... (TAS)
0007186 G-protein coupled receptor protein signalin... (NAS)
0015758 glucose transport (ISS)
0007202 phospholipase C activation (TAS)
0007585 respiratory gaseous exchange (ISS)
0007165 signal transduction (TAS)
0006939 smooth muscle contraction (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Endothelins play an important role in the regulation of the cardiovascularsystem . They are the most potent vasoconstrictors identified.timulatecardiac contraction.egulate release of vasoactive substances.ndstimulate mitogenesis in blood vessels in primary culture. They alsostimulate contraction in almost all other smooth muscles (e.g..terus.ronchus.as deferens.tomach) and stimulate secretion in several tissues(e.g..idney.iver and adrenals). Endothelin receptors have also beenfound in the brain..g. cerebral cortex.erebellum and glial cells.Endothelins have been implicated in a variety of pathophysiologicalconditions associated with stress.
  IPR000499:Endothelin receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Endothelins play an important role in the regulation of the cardiovascularsystem . They are the most potent vasoconstrictors identified.timulatecardiac constraction.egulate release of vasoactive substances.ndstimulate mitogenesis in blood vessels in primary culture. They alsostimulate contraction in almost all other smooth muscles (e.g..terus.ronchus.as deferens.tomach) and stimulate secretion in several tissues(e.g..idney.iver and adrenals). Endothelin receptors have also beenfound in the brain..g. cerebral cortex.erebellum and glial cells.Endothelins have been implicated in a variety of pathophysiologicalconditions associated with stress.The ETA receptor is the predominant type of endothelin receptor. Itmediates contraction in blood vessels.ronchus.terus and heart; it alsoinhibits aldosterone secretion. The receptors have been identified in glialcells in the CNS. They activate the phosphoinositide pathway through apertussis-toxin-insensitive G-protein.robably of the Gq/G11 class .
  IPR002175:Endothelin A receptor
IPR000276:7tm_1 
Evalue:-32.1549034118652 
Location:97-369IPR000499:ENDOTHELINR 
Evalue:0 
Location:69-88IPR002175:ENDOTHELINAR 
Evalue:0 
Location:390-409IPR002175:ENDOTHELINAR 
Evalue:0 
Location:8-26IPR002175:ENDOTHELINAR 
Evalue:0 
Location:27-44IPR002175:ENDOTHELINAR 
Evalue:0 
Location:412-426
SequencesProtein: EDNRA_HUMAN (427 aa)
mRNA: NM_001957
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04197
  Level 3 annotation:
    endothelin receptor type A
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 134 residues, 148621579-148621978Exon2: 165 residues, 148626213-148626703Exon3: 44 residues, 148660452-148660580Exon4: 68 residues, 148673107-148673306Exon5: 53 residues, 148676478-148676631Exon6: 46 residues, 148680418-148680552Exon7: 38 residues, 148680978-148681087Exon8: 827 residues, 148683079-148685555Exon9: 2 residues, -Jump to EDNRA_HUMAN  
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