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0EDG4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEDG4
DescriptionLysophosphatidic acid receptor edg-4 (lpa receptor 2) (lpa-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004930 G-protein coupled receptor activity (TAS)
0008289 lipid binding (TAS)
0007204 elevation of cytosolic calcium ion concentr... (TAS)
0007186 G-protein coupled receptor protein signalin... (TAS)
0007202 phospholipase C activation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Lysophospholipids (LPs).uch as lysophosphatidic acid (LPA).phingosine1-phosphate (S1P) and sphingosylphosphorylcholine (SPC).ave long been known to act as signalling molecules in addition to their roles as intermediates in membrane biosynthesis . They have roles in the regulation of cell growth.ifferentiation.poptosis and development.nd have been implicated in a wide range of pathophysiological conditions.ncluding: blood clotting.orneal wounding.ubarachinoid haemorrhage.nflammation and colitis . A number of G protein-coupled receptors bind members of the lysophopholipid family - these include: the cannabinoid receptors; platelet activating factor receptor; OGR1.n SPC receptor identified in ovarian cancer cell lines; PSP24.n orphan receptor that has been proposed to bind LPA; and at least 8 closely related receptors.he EDG family.hat bind LPA and S1P .LPA is found in all cell types in small quantities (associated with membranebiosynthesis) but is produced in significant quantities by some cellularsources.ccounting for the levels of LPA in serum. LPA is also found inelevated levels in ovarian cancer ascites.nd acts to stimulate proliferation and promote survival of the cancer cells . The effects of LPA on the proliferation and morphology of a number of other cell types have been well documented . However.dentification of the mechanisms by which these effects are accomplished has been complicated by a number of factors.uch as: a lack of antagonists.ifficulty in ligand-binding experiments and the responsiveness of many cell types to LPA . The G protein-coupled receptors EDG-2.DG-4 and EDG-7 have now been identifiedas high affinity receptors for LPA. It has been suggested that these receptors should now be referred to as lpA1.pA2 and lpA3 respectively .
  IPR004065:Lysophosphatidic acid receptor
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Lysophospholipids (LPs).uch as lysophosphatidic acid (LPA).phingosine1-phosphate (S1P) and sphingosylphosphorylcholine (SPC).ave long been known to act as signalling molecules in addition to their roles as intermediates in membrane biosynthesis . They have roles in the regulation of cell growth.ifferentiation.poptosis and development.nd have been implicated in a wide range of pathophysiological conditions.ncluding: blood clotting.orneal wounding.ubarachinoid haemorrhage.nflammation and colitis . A number of G protein-coupled receptors bind members of the lysophopholipid family - these include: the cannabinoid receptors; platelet activating factor receptor; OGR1.n SPC receptor identified in ovarian cancer cell lines; PSP24.n orphan receptor that has been proposed to bind LPA; and at least 8 closely related receptors.he EDG family.hat bind LPA and S1P .LPA is found in all cell types in small quantities (associated with membranebiosynthesis) but is produced in significant quantities by some cellularsources.ccounting for the levels of LPA in serum. LPA is also found inelevated levels in ovarian cancer ascites.nd acts to stimulate proliferation and promote survival of the cancer cells . The effects of LPA on the proliferation and morphology of a number of other cell types have been well documented . However.dentification of the mechanisms by which these effects are accomplished has been complicated by a number of factors.uch as: a lack of antagonists.ifficulty in ligand-binding experiments and the responsiveness of many cell types to LPA . The G protein-coupled receptors EDG-2.DG-4 and EDG-7 have now been identifiedas high affinity receptors for LPA. It has been suggested that these receptors should now be referred to as lpA1.pA2 and lpA3 respectively .EDG-4 is expressed at high levels in the testis and peripheral bloodleukocytes of humans.nd the testis.idney and embryonic brain in mouse.Lower levels of expression are found in human pancreas.pleen.hymus andprostate.nd mouse heart.ung.pleen.hymus.tomach and brain . Variant forms of the receptor are also expressed in cancer cells . Binding of LPA to EDG-4 results in increased calcium levels.nhibition of adenyly cylase.ctivation of MAP kinases and cell rounding.hrough coupling to Gi/o.q/11 and G12/13 proteins .
  IPR004066:EDG-4 lysophosphatidic acid receptor
IPR000276:7tm_1 
Evalue:-32.5086364746094 
Location:49-295IPR004066:EDG4RECEPTOR 
Evalue:0 
Location:313-325IPR004066:EDG4RECEPTOR 
Evalue:0 
Location:336-348IPR004066:EDG4RECEPTOR 
Evalue:0 
Location:23-34IPR004065:LPARECEPTOR 
Evalue:0 
Location:7-16
SequencesProtein: EDG4_HUMAN (351 aa)
mRNA: NM_004720
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK04291
  Level 3 annotation:
    endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 301 residues, 19595476-19596378Exon2: 270 residues, 19598351-19599155Exon3: 41 residues, 19599900-19600017Exon4: 2 residues, -Jump to EDG4_HUMAN  
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