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0ECHB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHADHB
DescriptionTrifunctional enzyme beta subunit, mitochondrial precursor (tp-beta) .
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005740 mitochondrial membrane (TAS)
0003857 3-hydroxyacyl-CoA dehydrogenase activity (TAS)
0003988 acetyl-CoA C-acyltransferase activity (TAS)
0004300 enoyl-CoA hydratase activity (TAS)
0006635 fatty acid beta-oxidation (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Two different types of thiolase are found both in eukaryotes and in prokaryotes: acetoacetyl-CoA thiolase () and 3-ketoacyl-CoA thiolase (). 3-ketoacyl-CoA thiolase (also called thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. Acetoacetyl-CoA thiolase (also called thiolase II) is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or steroid biogenesis.In eukaryotes.here are two forms of 3-ketoacyl-CoA thiolase: one located in the mitochondrion and the other in peroxisomes.There are two conserved cysteine residues important for thiolase activity. The first located in the N-terminal section of the enzymes is involved in the formation of an acyl-enzyme intermediate; the second located at the C-terminal extremity is the active site base involved in deprotonation in the condensation reaction.Mammalian nonspecific lipid-transfer protein (nsL-TP) (also known as sterol carrier protein 2) is a protein which seems to exist in two different forms: a 14 Kd protein (SCP-2) and a larger 58 Kd protein (SCP-x). The former is found in the cytoplasm or the mitochondria and is involved in lipid transport; the latter is found in peroxisomes. The C-terminal part of SCP-x is identical to SCP-2 while the N-terminal portion is evolutionary related to thiolases .
  IPR002155:Thiolase
IPR002155:Thiolase_N 
Evalue:-126.853874206543 
Location:52-325IPR002155:Thiolase_C 
Evalue:-79.3098068237305 
Location:332-472IPR000408:RCC1_2 
Evalue:0 
Location:0-0
SequencesProtein: ECHB_HUMAN (475 aa)
mRNA: NM_000183
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK00632
  Level 3 annotation:
    acetyl-CoA acyltransferase
  Level 2 annotation:
    Fatty acid metabolism
    Bile acid biosynthesis
    Valine
     leucine and isoleucine degradation
    Benzoate degradation via hydroxylation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 13 residues, 26321324-26321362Exon2: 26 residues, 26330618-26330690Exon3: 17 residues, 26330801-26330846Exon4: 35 residues, 26339751-26339851Exon5: 17 residues, 26346324-26346369Exon6: 35 residues, 26350022-26350122Exon7: 31 residues, 26353444-26353532Exon8: 64 residues, 26354985-26355173Exon9: 62 residues, 26355506-26355687Exon10: 42 residues, 26356365-26356487Exon11: 28 residues, 26359216-26359296Exon12: 18 residues, 26359375-26359423Exon13: 31 residues, 26360488-26360576Exon14: 27 residues, 26361254-26361329Exon15: 57 residues, 26361778-26361943Exon16: 184 residues, 26366289-26366836Exon17: 2 residues, -Jump to ECHB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4427 26267012-26320993 ~-54K 20116(HADHA)(-)Loci: 3150 26321324-26366836 ~-46K 20117(HADHB)(+)Loci: 3149 26110477-26213782 ~-103K 20115(RAB10)(+)Link out to UCSC