SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0EAR2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameNR2F6
DescriptionOrphan nuclear receptor ear-2 (v-erba-related protein ear-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003677 DNA binding (TAS)
0003707 steroid hormone receptor activity (TAS)
0004887 thyroid hormone receptor activity (TAS)
0007165 signal transduction (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1258621847.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences ().onnected via a linker region to a C-terminal ligand-binding domain. In addition.ertain nuclear hormone receptors have an N-terminal modulatory domain (). The ligand-binding domain acts in response to ligand binding.hich caused a conformational change in the receptor to induce a response.hereby acting as a molecular switch to turn on transcriptional activity . For example.fter binding of the glucocorticoid receptor to the corticosteroid ligand.he receptor is induced to perform functions ranging from nuclear translocation.ligomerisation.ofactor/kinase/transcription factor association.nd DNA binding . The ligand-binding domain is a flexible unit.here the binding of a ligand stabilises its conformation.hich in turn favours coactivator binding to modify receptor activity ; the coactivator can bind to the activator function 2 (AF2) site at the C-terminal end of the ligand-binding domain . The binding of different ligands can alter the conformation of the ligand-binding domain.hich ultimately affects the DNA-binding specificity of the DNA-binding domain. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components. This entry represents the C-terminal ligand-binding domain.
  IPR000536:Nuclear hormone receptor, ligand-binding
This domain is found to the C terminus of C4 type zinc fingers () in metazoan steroid/thyroid hormone receptors. Proteins in this family include the chicken ovalbumin upstream promoter transcription factor (COUP-TF.lso known as NR2F) which functions as a transcriptional regulator and plays a major role in the development of the nervous system .
  IPR013629:Zinc finger, C4-type, C-terminal
Steroid or nuclear hormone receptors constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. The receptors function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. Nuclear hormone receptors consist of a highly conserved DNA-binding domain that recognises specific sequences.onnected via a linker region to a C-terminal ligand-binding domain (). In addition.ertain nuclear hormone receptors have an N-terminal modulatory domain (). The DNA-binding domain can elicit either an activating or repressing effect by binding to specific regions of the DNA known as hormone-response elements . These response elements position the receptors.nd the complexes recruited by them.lose to the genes of which transcription is affected. The DNA-binding domains of nuclear receptors consist of two zinc-nucleated modules and a C-terminal extension.here residues in the first zinc module determine the specificity of the DNA recognition and residues in the second zinc module are involved in dimerisation. The DNA-binding domain is furthermore involved in several other functions including nuclear localization.nd interaction with transcription factors and co-activators . This entry represents the two zinc finger modules involved in DNA-binding.
  IPR001628:Nuclear hormone receptor, DNA-binding
Steroid or nuclear hormone receptors (4A nuclear receptor.Rs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed orphan receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.
  IPR001723:Steroid hormone receptor
Steroid or nuclear hormone receptors (4A nuclear receptor.Rs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed orphan receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) genes encode transcription factors that belong to the orphan group of the steroid/thyroid hormone receptor superfamily . COUP-TF binds to the ovalbumin promoter and.n conjunction with the S300-II protein.timulates initiation of transcription. The protein binds to both direct repeats and palindromes of the 5-AGGTCA-3 motif. Murine homologues of members of the COUP-TF family.OUP-TF1.RP-1 and EAR2.ave been isolated and shown to be highly similar to their human counterparts . Although these three genes appear to be expressed in tissues derived from all three germ layers.OUP-TF1 and ARP-1 have been found to be expressed predominantly in the developing central nervous system in mutually exclusive domains. Strong ARP-1 expression has also been detected in lung and kidney . Results from such studies suggest an important role for the members of the COUP-TF family in the hormonal control of gene expression regulating embryogenesis.nd in thedevelopment and differentiation of the CNS.ncluding the specificationof diencephalic neuromeres .Synonym(s): 2F nuclear receptor
  IPR003068:Transcription factor COUP
Steroid or nuclear hormone receptors (4A nuclear receptor.Rs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions.ncluding control of embryonic development.ell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone.etinoids..5-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner . In addition to C-terminal ligand-binding domains.hese nuclear receptors contain a highly-conserved.-terminal zinc-finger that mediates specific binding to target DNA sequences.ermed ligand-responsive elements. In the absence of ligand.teroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research. large number of them being implicated in diseases such as cancer.iabetes.ormone resistance syndromes.tc. While several NRs act as ligand-inducible transcription factors.any do not yet have a defined ligand and are accordingly termed orphan receptors. During the last decade.ore than 300 NRs have been described.any of which are orphans.hich cannot easily be named due to current nomenclature confusions in the literature. However. new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR008946:Nuclear receptor, ligand-binding
IPR000536:Hormone_recep 
Evalue:-59.2146682739258 
Location:207-389IPR001628:zf-C4 
Evalue:-55.1426658630371 
Location:54-129IPR013629:zf-C4_C 
Evalue:-8.06048107147217 
Location:140-205IPR008946:Str_ncl_receptor 
Evalue:0 
Location:4-15
SequencesProtein: EAR2_HUMAN (404 aa)
mRNA: NM_005234
Local Annotation
Synapse Ontology
the generation of action potential at soma of neurons.
sdb:0313 generation of AP at soma  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 248 residues, 17203694-17204435Exon2: 191 residues, 17207307-17207874Exon3: 33 residues, 17212479-17212574Exon4: 135 residues, 17216751-17217151Exon5: 2 residues, -Jump to EAR2_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4379 17203694-17217151 ~-13K 18279(NR2F6)(-)Loci: 3097 17187167-17191638 ~-4K 18275(USE1L)(+)Link out to UCSC