SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0EAA4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC1A6
DescriptionExcitatory amino acid transporter 4 (sodium-dependent glutamate/aspartate transporter).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005624 membrane fraction (TAS)
0015183 L-aspartate transporter activity (TAS)
0015810 L-aspartate transport (TAS)
0015813 L-glutamate transport (TAS)
0007268 synaptic transmission (TAS)

Warning: fopen(/home/kongl/syndb/www/temp/1209013.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
It has been shown that integral membrane proteins that mediate the uptakeof a wide variety of molecules with the concomitant uptake of sodium ions(sodium symporters) can be grouped.n the basis of sequence and functionalsimilarities into a number of distinct families. One of these families isknown as the sodium:dicarboxylate symporter family (SDF).Such re-uptake of neurotransmitters from the synapses.s thought to be an important mechanism for terminating their action.y removing these chemicals from the synaptic cleft.nd transporting them into presynaptic nerve terminals.nd surrounding neuroglia. this removal is also believed to prevent them accumulating to the point of reaching neurotoxic .The structure of these transporter proteins has been variously reported tocontain from 8 to 10 transmembrane (TM) regions.lthough 10 now seems tobe the accepted value.Members of the family include: several mammalian excitatory amino acid transporters.nd a number of bacterial transporters. They vary with regars to their dependence on transport of sodium.nd other ions.
  IPR001991:Sodium:dicarboxylate symporter
IPR001991:SDF 
Evalue:-210.88606262207 
Location:58-522
SequencesProtein: EAA4_HUMAN (564 aa)
mRNA: NM_005071
Local Annotation
Synapse Ontology
Na channel plays an important role in the course of action potential.
sdb:0287 Na channel  (Evidence:keywords)
KO assignmentK05617
  Level 3 annotation:
    solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
  Level 2 annotation:
    Other ion-coupled transporters
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 71 residues, 14921990-14922202Exon2: 47 residues, 14924739-14924874Exon3: 67 residues, 14925946-14926141Exon4: 80 residues, 14928287-14928521Exon5: 116 residues, 14933813-14934157Exon6: 16 residues, 14936130-14936173Exon7: 70 residues, 14940114-14940319Exon8: 48 residues, 14943548-14943686Exon9: 73 residues, 14944517-14944730Exon10: 2 residues, -Jump to EAA4_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4372 14380630-14391171 ~-11K 18171(DDX39)(-)Loci: 3093 14430110-14443670 ~-14K 18178(+)Loci: 4373 14852137-14853264 ~-1K 18201(-)Loci: 4374 14921990-14944730 ~-23K 18203(SLC1A6)(-)Loci: 4375 15325340-15351603 ~-26K 18217(AKAP8)(-)Loci: 4376 15351858-15390833 ~-39K 18218(AKAP8L)(-)Loci: 3094 15699833-15700862 ~-1K 18230(OR10H2)(+)Loci: 4377 15778890-15779847 ~-1K 18231(OR10H1)(-)Loci: 3095 16083489-16105443 ~-22K 18238(RAB8A)(+)Loci: 3096 16169730-16207156 ~-37K 18242(AP1M1)(+)Loci: 4378 16333407-16443762 ~-110K 18245(EPS15L1)(-)Loci: 4371 14119550-14177997 ~-58K 18165(LPHN1)(-)Link out to UCSC