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0EAA2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC1A2
DescriptionExcitatory amino acid transporter 2 (sodium-dependent glutamate/aspartate transporter 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005624 membrane fraction (TAS)
0005313 L-glutamate transporter activity (TAS)
0015813 L-glutamate transport (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
It has been shown that integral membrane proteins that mediate the uptakeof a wide variety of molecules with the concomitant uptake of sodium ions(sodium symporters) can be grouped.n the basis of sequence and functionalsimilarities into a number of distinct families. One of these families isknown as the sodium:dicarboxylate symporter family (SDF).Such re-uptake of neurotransmitters from the synapses.s thought to be an important mechanism for terminating their action.y removing these chemicals from the synaptic cleft.nd transporting them into presynaptic nerve terminals.nd surrounding neuroglia. this removal is also believed to prevent them accumulating to the point of reaching neurotoxic .The structure of these transporter proteins has been variously reported tocontain from 8 to 10 transmembrane (TM) regions.lthough 10 now seems tobe the accepted value.Members of the family include: several mammalian excitatory amino acid transporters.nd a number of bacterial transporters. They vary with regars to their dependence on transport of sodium.nd other ions.
  IPR001991:Sodium:dicarboxylate symporter
IPR001991:SDF 
Evalue:-259.180450439453 
Location:46-496
SequencesProtein: EAA2_HUMAN (574 aa)
mRNA: NM_004171
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
KO assignmentK05613
  Level 3 annotation:
    solute carrier family 1 (glial high affinity glutamate transporter), member 2
  Level 2 annotation:
    Other ion-coupled transporters
    Amyotrophic lateral sclerosis (ALS)
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 3254 residues, 35229328-35239088Exon2: 79 residues, 35243649-35243881Exon3: 47 residues, 35258989-35259124Exon4: 67 residues, 35264879-35265074Exon5: 80 residues, 35270409-35270643Exon6: 44 residues, 35279641-35279768Exon7: 58 residues, 35284196-35284365Exon8: 85 residues, 35290320-35290571Exon9: 53 residues, 35293145-35293298Exon10: 48 residues, 35295499-35295639Exon11: 102 residues, 35397072-35397372Exon12: 2 residues, -Jump to EAA2_HUMAN  
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