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0EAA1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameSLC1A3
DescriptionExcitatory amino acid transporter 1 (sodium-dependent glutamate/aspartate transporter 1) (glial glutamate transporter) (glast-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005624 membrane fraction (TAS)
0005313 L-glutamate transporter activity (TAS)
0015813 L-glutamate transport (TAS)
0001504 neurotransmitter uptake (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
It has been shown that integral membrane proteins that mediate the uptakeof a wide variety of molecules with the concomitant uptake of sodium ions(sodium symporters) can be grouped.n the basis of sequence and functionalsimilarities into a number of distinct families. One of these families isknown as the sodium:dicarboxylate symporter family (SDF).Such re-uptake of neurotransmitters from the synapses.s thought to be an important mechanism for terminating their action.y removing these chemicals from the synaptic cleft.nd transporting them into presynaptic nerve terminals.nd surrounding neuroglia. this removal is also believed to prevent them accumulating to the point of reaching neurotoxic .The structure of these transporter proteins has been variously reported tocontain from 8 to 10 transmembrane (TM) regions.lthough 10 now seems tobe the accepted value.Members of the family include: several mammalian excitatory amino acid transporters.nd a number of bacterial transporters. They vary with regars to their dependence on transport of sodium.nd other ions.
  IPR001991:Sodium:dicarboxylate symporter
IPR001991:SDF 
Evalue:-261.795867919922 
Location:50-497
SequencesProtein: EAA1_HUMAN (542 aa)
mRNA: NM_004172
Local Annotation
Synapse Ontology
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK05614
  Level 3 annotation:
    solute carrier family 1 (glial high affinity glutamate transporter), member 3
  Level 2 annotation:
    Other ion-coupled transporters
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 50 residues, 36642447-36642594Exon2: 94 residues, 36644187-36644463Exon3: 48 residues, 36665308-36665446Exon4: 70 residues, 36706887-36707092Exon5: 16 residues, 36709907-36709950Exon6: 99 residues, 36712750-36713043Exon7: 80 residues, 36715485-36715719Exon8: 67 residues, 36716253-36716448Exon9: 47 residues, 36719722-36719857Exon10: 758 residues, 36721923-36724191Exon11: 2 residues, -Jump to EAA1_HUMAN  
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Loci Cluster (Details)Loci: 3449 36912741-37101677 ~-189K 28716(NIPBL)(+)Loci: 3448 36642447-36724191 ~-82K 28713(SLC1A3)(+)Link out to UCSC