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0E2F1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameE2F1
DescriptionTranscription factor e2f1 (e2f-1) (retinoblastoma binding protein 3) (rbbp-3) (prb-binding protein e2f-1) (pbr3) (retinoblastoma-associated protein 1) (rbap-1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (IPI)
0003714 transcription corepressor activity (TAS)
0003700 transcription factor activity (TAS)
0006915 apoptosis (TAS)
0008283 cell proliferation (TAS)
0000080 G1 phase of mitotic cell cycle (TAS)
0000122 negative regulation of transcription from R... (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The mammalian transcription factor E2F plays an important role in regulating the expression of genes that are required for passage through the cell cycle. Multiple E2F family members have been identified that bind to DNA as heterodimers.nteracting with proteins known as DP - the dimerisation partners .
  IPR003316:Transcription factor E2F/dimerisation partner (TDP)
Winged helix DNA-binding proteins share a related winged helix-turn-helix DNA-binding motif.here the "wings".r loops.re small beta-sheets. The winged helix motif consists of two wings (W1.2).hree alpha helices (H1.2.3) and three beta-sheets (S1.2.3) arranged in the order H1-S1-H2-H3-S2-W1-S3-W2 . The DNA-recognition helix makes sequence-specific DNA contacts with the major groove of DNA.hile the wings make different DNA contacts.ften with the minor groove or the backbone of DNA. Several winged-helix proteins display an exposed patch of hydrophobic residues thought to mediate protein-protein interactions.Many different proteins with diverse biological functions contain a winged helix DNA-binding domain.ncluding transcriptional repressors such as biotin repressor.exA repressor and the arginine repressor ; transcription factors such as the hepatocyte nuclear factor-3 proteins involved in cell differentiation.eat-shock transcription factor.nd the general transcription factors TFIIE and TFIIF . helicases such as RuvB that promotes branch migration at the Holliday junction.nd CDC6 in the pre-replication complex . endonucleases such as FokI and TnsA ; histones; and Mu transposase.here the flexible wing of the enhancer-binding domain is essential for efficient transposition .
  IPR011991:Winged helix repressor DNA-binding
IPR003316:E2F_TDP 
Evalue:-34.5850257873535 
Location:127-192
SequencesProtein: E2F1_HUMAN (437 aa)
mRNA: NM_005225
Local Annotation
Synapse Ontology
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 433 residues, 31727149-31728446Exon2: 77 residues, 31728571-31728797Exon3: 40 residues, 31728892-31729007Exon4: 53 residues, 31729667-31729820Exon5: 75 residues, 31731221-31731441Exon6: 32 residues, 31731792-31731883Exon7: 130 residues, 31737470-31737854Exon8: 2 residues, -Jump to E2F1_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4516 31459423-31495359 ~-36K 22912(SNTA1)(-)Loci: 4517 31727149-31737854 ~-11K 22925(E2F1)(-)Loci: 3247 31862779-31905830 ~-43K 22928(CHMP4B)(+)Loci: 4515 31410305-31452998 ~-43K 22906(CDK5RAP1)(-)Link out to UCSC