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0E2AK3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameEIF2AK3
DescriptionEukaryotic translation initiation factor 2-alpha kinase 3 precursor (ec 2.7.1.-) (prkr-like endoplasmic reticulum kinase) (pancreatic eif2-alpha kinase) (hspek).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004672 protein kinase activity (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Eukaryotic protein kinases are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. There are a number of conserved regions in thecatalytic domain of protein kinases. In the N-terminal extremity of the catalytic domain there is aglycine-rich stretch of residues in the vicinity of a lysine residue.hich has been shown to be involvedin ATP binding. In the central part of the catalytic domain there is a conserved aspartic acid residuewhich is important for the catalytic activity of the enzyme . This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too.
  IPR000719:Protein kinase
Pyrrolo-quinoline quinone (PQQ) is a redox coenzyme.hich serves as a cofactor for a number of enzymes (quinoproteins) and particularly for some bacterial dehydrogenases . A number of bacterial quinoproteins belong to this family.Enzymes in this group have repeats of a beta propeller.
  IPR002372:Pyrrolo-quinoline quinone
Protein kinases () catalyze the phosphotransfer reaction fundamental to most signalling and regulatory processes in the eukaryotic cell . The catalytic subunit contains a core that is common to both serine/threonine and tyrosine protein kinases. The catalytic domain contains the nucleotide-binding site and the catalytic apparatus in an inter-lobe cleft. Structurally it shares functional and structural similarities with the ATP-grasp fold.hich is found in enzymes that catalyse the formation of an amide bond.nd with PIPK (phosphoinositol phosphate kinase). The three-dimensional fold of the protein kinase catalytic domain is similar to domains found in several other proteins. These include the catalytic domain of actin-fragmin kinase.n atypical protein kinase that regulates the F-actin capping activity in plasmodia ; the catalytic domain of phosphoinositide-3-kinase (PI3K).hich phosphorylates phosphoinositides and as such is involved in a number of fundamental cellular processes such as apoptosis.roliferation.otility and adhesion ; the catalytic domain of the MHCK/EF2 kinase.n atypical protein kinase that includes the TRP (transient channel potential) calcium-channel kinase involved in the modulation of calcium channels in eukaryotic cells in response to external signals ; choline kinase.hich catalyses the ATP-dependent phosphorylation of choline during the biosynthesis of phosphatidylcholine ; and 3.-aminoglycoside phosphotransferase type IIIa. bacterial enzyme that confers resistance to a range of aminoglycoside antibiotics .
  IPR011009:Protein kinase-like
Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase.ype II includes soluble quinohaemoprotein with a C-terminal containing haem C.nd type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain . These quinoproteins contain an 8-bladed beta-propeller motif.hich is present in the N-terminal domain of quinoprotein alcohol dehydrogenase.thanol dehydrogenase.nd the heavy chain (alpha subunit) of methanol dehydrogenase () .The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011047:Quinonprotein alcohol dehydrogenase-like
IPR000719:Pkinase 
Evalue:-37.6020584106445 
Location:592-1071IPR011047:Quin_alc_DH_like 
Evalue:0 
Location:85-431IPR002372:PQQ 
Evalue:0 
Location:0-0
SequencesProtein: E2AK3_HUMAN (1115 aa)
mRNA: NM_004836
Local Annotation
Synapse Ontology
A typical resting membrane potential for neurons varies from -65 to -90 mV. This potential represents the sum of the equilibrium potentials for each contributing ion.
sdb:0237 resting membrane potentiaion  (Evidence:keywords)
KO assignmentK00924
  Level 3 annotation:
    
  Level 2 annotation:
    Inositol phosphate metabolism
    Nicotinate and nicotinamide metabolism
    Benzoate degradation via CoA ligation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 399 residues, 88637375-88638569Exon2: 23 residues, 88639549-88639612Exon3: 36 residues, 88642921-88643023Exon4: 58 residues, 88651506-88651674Exon5: 262 residues, 88655298-88656079Exon6: 52 residues, 88657186-88657336Exon7: 43 residues, 88660150-88660273Exon8: 39 residues, 88664062-88664175Exon9: 75 residues, 88666473-88666694Exon10: 43 residues, 88668614-88668737Exon11: 49 residues, 88669393-88669534Exon12: 56 residues, 88671075-88671238Exon13: 80 residues, 88671450-88671685Exon14: 46 residues, 88673904-88674038Exon15: 67 residues, 88676101-88676296Exon16: 45 residues, 88694356-88694486Exon17: 160 residues, 88707599-88708074Exon18: 2 residues, -Jump to E2AK3_HUMAN  
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