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0DYNA_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDCTN1
DescriptionDynactin-1 (150 kda dynein-associated polypeptide) (dp-150) (dap-150) (p150-glued) (p135).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005737 cytoplasm (TAS)
0007067 mitosis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cytoskeleton-associated proteins (CAP) are made of three distinct parts.n N-terminal section that is most probably globular and contains the CAP-Gly domain. large central region predicted to be in an alpha-helical coiled-coil conformation and.inally. short C-terminal globular domain. The CAP-Gly domain is a conserved.lycine-rich domain of about 42 residues found in some CAPs . Proteins known to contain this domain include restin (also known as cytoplasmic linker protein-170 or CLIP-170). 160 kDa protein associated with intermediate filaments and that links endocytic vesicles to microtubules; vertebrate dynactin (150 kDa dynein-associated polypeptide; DAP) and Drosophila glued. major component of activator I; yeast protein BIK1.hich seems to be required for the formation orstabilisation of microtubules during mitosis and for spindle pole body fusion during conjugation; yeast protein NIP100 (NIP80); human protein CKAP1/TFCB; Schizosaccharomyces pombe protein alp11 and Caenorhabditis elegans hypothetical protein F53F4.3. The latter proteins contain a N-terminal ubiquitin domain and a C-terminal CAP-Gly domain. The crystal structure of the CAP-Gly domain of C. elegans F53F4.3 protein.olved by single wavelength sulphur-anomalous phasing.evealed a novel protein fold containing three beta-sheets. The most conserved sequence.KNDG.s located in two consecutive sharp turns on the surface.orming the entrance to a groove. Residues in the groove are highly conserved as measured from the information content of the aligned sequences. The C-terminal tail of another molecule in the crystal is bound in this groove .
  IPR000938:CAP-Gly
Tropomyosins .re a family of closely related proteins present in muscle and non-muscle cells. In striated muscle.ropomyosin mediate the interactions between the troponin complex and actin so as to regulate muscle contraction . The role of tropomyosin in smooth muscle and non-muscle tissues is not clear. Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites . There are multiple cell-specific isoforms.reated by differential splicing of the messenger RNA from one gene.ut the proportions of the isoforms vary between different cell types. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region.hereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.Some of the proteins in this family are allergens. Allergies are hypersensitivity reactions of the immune system to specific substances called allergens (such as pollen.tings.rugs.r food) that.n most people.esult in no symptoms. A nomenclature system has been established for antigens (allergens) that cause IgE-mediated atopic allergies in humans [WHO/IUIS Allergen Nomenclature Subcommittee King T.P..offmann D..oewenstein H..arsh D.G..latts-Mills T.A.E..homas W. Bull. World Health Organ. 72:797-806(1994)]. This nomenclature system is defined by a designation that is composed ofthe first three letters of the genus; a space; the first letter of thespecies name; a space and an arabic number. In the event that two speciesnames have identical designations.hey are discriminated from one anotherby adding one or more letters (as necessary) to each species designation. The allergens in this family include allergens with the following designations: Met e 1.
  IPR000533:Tropomyosin
IPR000938:CAP_GLY 
Evalue:-36.0604820251465 
Location:29-95IPR000533:TROPOMYOSIN 
Evalue:0 
Location:0-0
SequencesProtein: DYNA_HUMAN (1278 aa)
mRNA: BX640799 NM_004082
Local Annotation
Synapse Ontology
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
?
sdb:0247 cytoskeleton protein transport  (Evidence:keywords)
?
sdb:0329 actin in synaptic vesicle cycling  (Evidence:keywords)
KO assignmentK04648
  Level 3 annotation:
    dynactin 1
  Level 2 annotation:
    Huntington's disease
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 161 residues, 74441789-74442271Exon2: 32 residues, 74442686-74442776Exon3: 28 residues, 74443284-74443364Exon4: 63 residues, 74443628-74443812Exon5: 46 residues, 74443928-74444062Exon6: 7 residues, 74444248-74444263Exon7: 57 residues, 74445709-74445876Exon8: 49 residues, 74446149-74446292Exon9: 44 residues, 74446527-74446653Exon10: 46 residues, 74446878-74447010Exon11: 56 residues, 74447093-74447255Exon12: 52 residues, 74447417-74447567Exon13: 23 residues, 74447679-74447742Exon14: 25 residues, 74447986-74448055Exon15: 58 residues, 74448330-74448499Exon16: 55 residues, 74448605-74448766Exon17: 53 residues, 74449362-74449515Exon18: 41 residues, 74449732-74449849Exon19: 66 residues, 74449934-74450126Exon20: 37 residues, 74450599-74450704Exon21: 55 residues, 74450820-74450980Exon22: 28 residues, 74451100-74451179Exon23: 70 residues, 74451255-74451460Exon24: 68 residues, 74451613-74451811Exon25: 66 residues, 74452171-74452363Exon26: 9 residues, 74453562-74453583Exon27: 8 residues, 74454957-74454975Exon28: 9 residues, 74457376-74457397Exon29: 13 residues, 74458066-74458101Exon30: 28 residues, 74458282-74458361Exon31: 84 residues, 74458634-74458880Exon32: 279 residues, 74460639-74461472Exon33: 2 residues, -Jump to DYNA_HUMANExon1: 160 residues, 74441793-74442271Exon2: 32 residues, 74442686-74442776Exon3: 28 residues, 74443284-74443364Exon4: 63 residues, 74443628-74443812Exon5: 46 residues, 74443928-74444062Exon6: 7 residues, 74444248-74444265Exon7: 57 residues, 74445711-74445876Exon8: 49 residues, 74446149-74446292Exon9: 44 residues, 74446527-74446653Exon10: 46 residues, 74446878-74447010Exon11: 56 residues, 74447093-74447255Exon12: 52 residues, 74447417-74447567Exon13: 23 residues, 74447679-74447742Exon14: 25 residues, 74447986-74448055Exon15: 58 residues, 74448330-74448499Exon16: 55 residues, 74448605-74448766Exon17: 53 residues, 74449362-74449515Exon18: 41 residues, 74449732-74449849Exon19: 66 residues, 74449934-74450126Exon20: 37 residues, 74450599-74450704Exon21: 55 residues, 74450820-74450980Exon22: 28 residues, 74451100-74451179Exon23: 70 residues, 74451255-74451460Exon24: 68 residues, 74451613-74451811Exon25: 66 residues, 74452171-74452363Exon26: 9 residues, 74453562-74453583Exon27: 8 residues, 74454957-74454975Exon28: 9 residues, 74457376-74457397Exon29: 13 residues, 74458066-74458101Exon30: 28 residues, 74458282-74458361Exon31: 84 residues, 74458634-74458880Exon32: 44 residues, 74460639-74460767Exon33: 2 residues, -Jump to DYNA_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3171 73973600-74000287 ~-27K 20655(ACTG2)(+)Loci: 3172 74007460-74039594 ~-32K 20656(DGUOK)(+)Loci: 4449 74441789-74461472 ~-20K 20675(DCTN1)(-)Loci: 4450 74613453-74634593 ~-21K 20704(LOXL3)(-)Loci: 3170 73909654-73943518 ~-34K 20654(STAMBP)(+)Link out to UCSC