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0DYHC_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDNCH1
DescriptionDynein heavy chain, cytosolic (dyhc) (cytoplasmic dynein heavy chain 1) (dhc1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005868 cytoplasmic dynein complex (NAS)
0042623 ATPase activity, coupled (NAS)
0003777 microtubule motor activity (NAS)
0007018 microtubule-based movement (NAS)
0007052 mitotic spindle organization and biogenesis (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein is composed of a number of ATP-binding large subunits.ntermediate size subunits and small subunits (see ). This family represents the C-terminal region of dynein heavy chain. The dynein heavy chain also exhibits ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules.
  IPR004273:Dynein heavy chain
Dynein heavy chains interact with other heavy chains to form dimers.nd with intermediate chain-light chain complexes to form a basal cargo binding unit . The region featured in this family includes the sequences implicated in mediating these interactions . It is thought to be flexible and not to adopt a rigid conformation .
  IPR013594:Dynein heavy chain, N-terminal region 1
Dyneins are described as motor proteins of eukaryotic cells.s they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers.uch as microtubules. Dyneins generally contain one to three heavy chains.here each heavy chain consists of a C-terminal globular head. flexible microtubule-binding stalk.nd a flexible N-terminal tail known as the cargo-binding domain . The two categories of dyneins are the axonemal dyneins.hich produce the bending motions that propagate along cilia and flagella.nd the cytosolic dyneins.hich drive a variety of fundamental cellular processes including nuclear migration.rganization of the mitotic spindle.hromosome separation during mitosis.nd the positioning and function of many intracellular organelles. Cytoplasmic dyneins contain several accessory subunits ranging from light to intermediate chains.This entry represents a region found C-terminal to the dynein heavy chain N-terminal region 1 () in many members of this family. No functions seem to have been attributed specifically to this region.
  IPR013602:Dynein heavy chain, N-terminal region 2
This entry includes some of the AAA proteins not detected by the model.
  IPR011704:ATPase associated with various cellular activities, AAA-5
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes . Repeated WD40 motifs act as a site for protein-protein interaction.nd proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. In Arabidopsis sp..everal WD40-containig proteins act as key regulators of plant-specific developmental events. WD40 repeats usually assume a 7-8 bladed beta-propeller fold.ut proteins have been found with 4 to 16 repeated units.The structures of several WD40 repeat-containing proteins have been determined.ncluding the beta-1 subunit of the signal-transducing G protein heterotrimer.he C-terminal domain of yeast Tup1.he C-terminal domain of Groucho/tle1.he Cdc4 propeller domain.he bovine Arp2/3 complex 41 kDa subunit ARPC1.nd actin interacting protein 1. The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011046:WD40-like
Several biological processes regulate the activity of target proteins through changes in the redox state of thiol groups (S2 to SH2).here a hydrogen donor is linked to an intermediary disulphide protein. Such processes include the ferredoxin/thioredoxin system.he NADP/thioredoxin system.nd the glutathione/glutaredoxin system . Several of these disulphide proteins share a common structure.onsisting of a three-layer alpha/beta/alpha core. Proteins that contain this thioredoxin fold include: 2Fe-2S ferredoxin.hioltransferase.hosducin.lutathione peroxidase-like enzymes.rsenate reductase.isulphide bond isomerase DsbC (C-terminal domain).isulphide bond facilitator DsbA (contains an alpha-helical insertion).lutathione S-transferase (N-terminal domain).ndoplasmic reticulum protein ERP29 (N-terminal domain).pliceosomal protein U5-15Kd.ircadian oscillation regulator KaiB.rotein disulphide isomerase PDI (contains two tandem repeats of this fold).nd calsequestrin (contains three tandem repeats of this fold).This entry differs from the thioredoxin-like fold protein.he classification of this fold in glutathione S-transferase enzymes.here this entry defines two regions containing this fold.nd the thioredoxin-like fold protein defines only the N-terminal as containing this fold.
  IPR012335:Thioredoxin fold
IPR004273:Dynein_heavy 
Evalue:-1e+125 
Location:3915-4645IPR013594:DHC_N1 
Evalue:-261.886047363281 
Location:238-834IPR013602:DHC_N2 
Evalue:-212.124938964844 
Location:1317-1725IPR011704:AAA_5 
Evalue:-15.8538722991943 
Location:2219-2367IPR003593:AAA 
Evalue:-6.07572071393812 
Location:2587-2737IPR003593:AAA 
Evalue:-4.32790214206428 
Location:2929-3095IPR003593:AAA 
Evalue:-1.26760624017703 
Location:1901-2045
SequencesProtein: DYHC_HUMAN (4646 aa)
mRNA: NM_001376
Local Annotation
Synapse Ontology
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
It carries vesicles and organelles from the soma toward the axon terminal (anterograde transport) or vesicles containing sampled extracellular material from the terminal to the soma (retrograde transport)
sdb:0244 organelle and vesicle transport  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 101 residues, 101500736-101501037Exon2: 31 residues, 101511801-101511889Exon3: 60 residues, 101515408-101515582Exon4: 87 residues, 101515808-101516064Exon5: 64 residues, 101516453-101516640Exon6: 92 residues, 101519108-101519380Exon7: 78 residues, 101519471-101519699Exon8: 361 residues, 101521776-101522853Exon9: 62 residues, 101523542-101523722Exon10: 52 residues, 101524792-101524942Exon11: 51 residues, 101527616-101527763Exon12: 49 residues, 101530273-101530414Exon13: 61 residues, 101530762-101530939Exon14: 39 residues, 101531075-101531186Exon15: 42 residues, 101531270-101531390Exon16: 82 residues, 101533124-101533364Exon17: 54 residues, 101536078-101536234Exon18: 40 residues, 101536375-101536489Exon19: 39 residues, 101537043-101537154Exon20: 72 residues, 101537234-101537444Exon21: 51 residues, 101537624-101537771Exon22: 57 residues, 101538626-101538793Exon23: 60 residues, 101538881-101539055Exon24: 57 residues, 101540607-101540773Exon25: 65 residues, 101540851-101541040Exon26: 67 residues, 101541131-101541326Exon27: 96 residues, 101541977-101542260Exon28: 35 residues, 101543097-101543198Exon29: 55 residues, 101544267-101544427Exon30: 83 residues, 101545932-101546176Exon31: 63 residues, 101546365-101546549Exon32: 73 residues, 101546829-101547042Exon33: 81 residues, 101547964-101548203Exon34: 54 residues, 101548403-101548560Exon35: 78 residues, 101551194-101551422Exon36: 79 residues, 101551945-101552176Exon37: 49 residues, 101552438-101552579Exon38: 80 residues, 101552855-101553089Exon39: 71 residues, 101553177-101553384Exon40: 42 residues, 101553472-101553594Exon41: 57 residues, 101554540-101554706Exon42: 56 residues, 101555982-101556146Exon43: 45 residues, 101558840-101558970Exon44: 46 residues, 101562663-101562797Exon45: 40 residues, 101563263-101563378Exon46: 56 residues, 101563472-101563634Exon47: 73 residues, 101563708-101563923Exon48: 70 residues, 101564026-101564231Exon49: 60 residues, 101565628-101565802Exon50: 42 residues, 101565908-101566028Exon51: 42 residues, 101566251-101566372Exon52: 67 residues, 101568361-101568557Exon53: 41 residues, 101569154-101569272Exon54: 74 residues, 101569358-101569574Exon55: 73 residues, 101570065-101570278Exon56: 44 residues, 101570414-101570542Exon57: 53 residues, 101572578-101572732Exon58: 51 residues, 101574549-101574696Exon59: 52 residues, 101574787-101574938Exon60: 86 residues, 101575090-101575344Exon61: 47 residues, 101575501-101575636Exon62: 33 residues, 101575727-101575822Exon63: 60 residues, 101576325-101576500Exon64: 27 residues, 101576687-101576763Exon65: 55 residues, 101577663-101577824Exon66: 39 residues, 101578102-101578214Exon67: 22 residues, 101578317-101578378Exon68: 43 residues, 101578473-101578597Exon69: 40 residues, 101578724-101578838Exon70: 59 residues, 101579964-101580135Exon71: 74 residues, 101580363-101580581Exon72: 36 residues, 101580684-101580788Exon73: 72 residues, 101583906-101584118Exon74: 53 residues, 101584605-101584759Exon75: 49 residues, 101585529-101585672Exon76: 58 residues, 101585803-101585972Exon77: 44 residues, 101586160-101586288Exon78: 123 residues, 101586524-101586887Exon79: 2 residues, -Jump to DYHC_HUMAN  
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Loci Cluster (Details)Loci: 4153 101616858-101675776 ~-59K 11788(HSPCA)(-)Loci: 2863 101500736-101586887 ~-86K 11786(DNCH1)(+)Link out to UCSC