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0DYH5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDNAH5
DescriptionCiliary dynein heavy chain 5 (axonemal beta dynein heavy chain 5) (hl1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003777 microtubule motor activity (NAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Dynein is a multisubunit microtubule-dependent motor enzyme that acts as the force generating protein of eukaryotic cilia and flagella. The cytoplasmic isoform of dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein is composed of a number of ATP-binding large subunits.ntermediate size subunits and small subunits (see ). This family represents the C-terminal region of dynein heavy chain. The dynein heavy chain also exhibits ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules.
  IPR004273:Dynein heavy chain
Dynein heavy chains interact with other heavy chains to form dimers.nd with intermediate chain-light chain complexes to form a basal cargo binding unit . The region featured in this family includes the sequences implicated in mediating these interactions . It is thought to be flexible and not to adopt a rigid conformation .
  IPR013594:Dynein heavy chain, N-terminal region 1
Dyneins are described as motor proteins of eukaryotic cells.s they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers.uch as microtubules. Dyneins generally contain one to three heavy chains.here each heavy chain consists of a C-terminal globular head. flexible microtubule-binding stalk.nd a flexible N-terminal tail known as the cargo-binding domain . The two categories of dyneins are the axonemal dyneins.hich produce the bending motions that propagate along cilia and flagella.nd the cytosolic dyneins.hich drive a variety of fundamental cellular processes including nuclear migration.rganization of the mitotic spindle.hromosome separation during mitosis.nd the positioning and function of many intracellular organelles. Cytoplasmic dyneins contain several accessory subunits ranging from light to intermediate chains.This entry represents a region found C-terminal to the dynein heavy chain N-terminal region 1 () in many members of this family. No functions seem to have been attributed specifically to this region.
  IPR013602:Dynein heavy chain, N-terminal region 2
This entry includes some of the AAA proteins not detected by the model.
  IPR011704:ATPase associated with various cellular activities, AAA-5
AAA ATPases form a large.unctionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases.hich exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase domain.hich is the most abundant class of NTP-binding protein fold.nd is found throughout all kingdoms of life . P-loop NTPase domains act to hydrolyse the beta-gamma phosphate bond of bound nucleoside triphosphate. There are two classes of P-loop domains: the KG (kinase-GTPase) division.nd the ASCE division.he latter including the AAA+ group as well as several other ATPases.There are at least six major clades of AAA domains (metalloproteases.eiotic proteins.1 and D2 domains of ATPases with two AAA domains.roteasome subunits.nd BSC1).s well as several minor clades.ome of which consist of hypothetical proteins . The domain organisation of AAA ATPases consists of a non-ATPase N-terminal domain that acts in substrate recognition.ollowed by one or two AAA domains (D1 and D2).ne of which may be degenerate.
  IPR003593:AAA ATPase
This domain consists of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix.here the repeats that make up this structure are arranged about a common axis . These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. This topology has been found with a number of repeats and domains.ncluding the armadillo repeat (found in beta-catenins and importins).he HEAT repeat (found in protein phosphatase 2a and initiation factor eIF4G).he PHAT domain (found in Smaug RNA-binding protein).he leucine-rich repeat variant.he Pumilo repeat.nd in the H regulatory subunit of V-type ATPases. The sequence similarity among these different repeats or domains is low.owever they exhibit considerable structural similarity. Furthermore.he number of repeats present in the superhelical structure can vary between orthologues.ndicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats .
  IPR011989:Armadillo-like helical
IPR004273:Dynein_heavy 
Evalue:-255.53759765625 
Location:3927-4622IPR013594:DHC_N1 
Evalue:-219.769546508789 
Location:246-804IPR013602:DHC_N2 
Evalue:-190.346786499023 
Location:1400-1812IPR011704:AAA_5 
Evalue:-6.76955127716064 
Location:2257-2401IPR003593:AAA 
Evalue:-1.18045606445813 
Location:2582-2780IPR003593:AAA 
Evalue:-0.823908740944319 
Location:1975-2111
SequencesProtein: DYH5_HUMAN (4624 aa)
mRNA: NM_001369
Local Annotation
Synapse Ontology
The directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
sdb:0057 axon transport  (Evidence:keywords)
microtubules of the presynaptic compartment function as the tracks for the intense traffic of organelles from cell body to axon terminals and vice versa. It is generally excluded from the presynaptic vesicle cluster.Microtubules do not directly regulate synapse morphology or function
sdb:0087 microtubules  (Evidence:keywords)
It carries vesicles and organelles from the soma toward the axon terminal (anterograde transport) or vesicles containing sampled extracellular material from the terminal to the soma (retrograde transport)
sdb:0244 organelle and vesicle transport  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 69 residues, 13745038-13745244Exon2: 79 residues, 13753748-13753980Exon3: 53 residues, 13754392-13754545Exon4: 73 residues, 13761231-13761444Exon5: 74 residues, 13767513-13767729Exon6: 70 residues, 13769595-13769799Exon7: 70 residues, 13770423-13770629Exon8: 75 residues, 13771990-13772210Exon9: 84 residues, 13774108-13774354Exon10: 52 residues, 13780615-13780765Exon11: 42 residues, 13782547-13782669Exon12: 65 residues, 13788239-13788430Exon13: 40 residues, 13788926-13789041Exon14: 83 residues, 13790360-13790604Exon15: 63 residues, 13804186-13804369Exon16: 54 residues, 13805242-13805398Exon17: 107 residues, 13806341-13806658Exon18: 47 residues, 13807311-13807447Exon19: 48 residues, 13811954-13812092Exon20: 62 residues, 13815830-13816010Exon21: 70 residues, 13819084-13819288Exon22: 61 residues, 13822068-13822245Exon23: 40 residues, 13822609-13822724Exon24: 79 residues, 13823857-13824089Exon25: 91 residues, 13829547-13829815Exon26: 53 residues, 13830310-13830464Exon27: 45 residues, 13833937-13834068Exon28: 59 residues, 13839287-13839460Exon29: 68 residues, 13841824-13842023Exon30: 76 residues, 13845102-13845326Exon31: 73 residues, 13846623-13846837Exon32: 43 residues, 13847044-13847167Exon33: 47 residues, 13860699-13860834Exon34: 49 residues, 13862152-13862295Exon35: 69 residues, 13863167-13863369Exon36: 61 residues, 13864755-13864932Exon37: 82 residues, 13867713-13867955Exon38: 51 residues, 13870656-13870803Exon39: 53 residues, 13873454-13873608Exon40: 38 residues, 13876371-13876479Exon41: 47 residues, 13877307-13877442Exon42: 67 residues, 13882618-13882813Exon43: 64 residues, 13883134-13883322Exon44: 61 residues, 13883705-13883884Exon45: 59 residues, 13892464-13892637Exon46: 77 residues, 13894014-13894239Exon47: 73 residues, 13894800-13895013Exon48: 54 residues, 13897945-13898102Exon49: 56 residues, 13903760-13903924Exon50: 53 residues, 13912560-13912714Exon51: 68 residues, 13915656-13915856Exon52: 82 residues, 13917505-13917746Exon53: 81 residues, 13918776-13919015Exon54: 23 residues, 13919328-13919391Exon55: 75 residues, 13920882-13921101Exon56: 80 residues, 13923875-13924111Exon57: 69 residues, 13924672-13924874Exon58: 46 residues, 13929792-13929926Exon59: 31 residues, 13935836-13935924Exon60: 65 residues, 13936012-13936203Exon61: 82 residues, 13938097-13938337Exon62: 57 residues, 13939072-13939238Exon63: 50 residues, 13944084-13944230Exon64: 59 residues, 13947758-13947930Exon65: 71 residues, 13953314-13953521Exon66: 109 residues, 13954360-13954682Exon67: 30 residues, 13955161-13955247Exon68: 38 residues, 13964494-13964602Exon69: 74 residues, 13966851-13967067Exon70: 43 residues, 13967628-13967751Exon71: 38 residues, 13969456-13969564Exon72: 40 residues, 13970251-13970365Exon73: 61 residues, 13972284-13972461Exon74: 48 residues, 13973588-13973726Exon75: 76 residues, 13975215-13975437Exon76: 55 residues, 13976388-13976549Exon77: 30 residues, 13981202-13981287Exon78: 47 residues, 13984218-13984353Exon79: 35 residues, 13997490-13997589Exon80: 2 residues, -Jump to DYH5_HUMAN  
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