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0DTNB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDTNB
DescriptionDystrobrevin beta (beta-dystrobrevin) (dtn-b).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005515 protein binding (TAS)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Skeletal muscle dystrophin is a 427 kDa protein thought to act as a link between the actin cytoskeleton and the extracellular matrix. Perturbations of the dystrophin-associated complex.or example.etween dystrophin and the transmembrane glycoprotein beta-dystroglycan.ay lead to muscular dystrophy. Previously.he cysteine-rich region and first half of the carboxy-terminal domain of dystrophin were shown to interact with beta-dystroglycan through a stretch of fifteen amino acids at the carboxy-terminus of beta-dystroglycan. This region of dystrophin implicated in binding beta-dystroglycan contains four modular protein domains: a WW domain.wo putative Ca2+-binding EF-hand motifs.nd a putative zinc finger ZZ domain .
  IPR000433:Zinc finger, ZZ-type
Pentatricopeptide repeat proteins are characterised by the presence of a tandem array of repeats.here the number of PPR motifs controls the affinity and specificity of the PPR protein for RNA. These proteins occur predominantly in plants.here they appear to play essential roles in RNA/DNA metabolism in mitochondria and chloroplasts . It has been suggested that each of the highly variable PPR proteins is a gene-specific regulator of plant organellar RNA metabolism. PPR proteins may also play a role in organelle biogenesis.robably via binding to organellar transcripts . Examples of PPR repeat-containing proteins include PET309 .hich may be involved in RNA stabilisation .nd crp1.hich is involved in RNA processing . The repeat is associated with a predicted plant protein that has a domain organization similar to the human BRCA1 protein.
  IPR002885:Pentatricopeptide repeat
This domain consists of a duplication of two EF-hand units.here each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain . These include: calbindin D9K.100 proteins such as calcyclin.olcalcin phl p 7 (a calcium-binding pollen allergen).steonectin.arvalbumin.almodulin family of proteins (troponin C.altractin.dc4p.yosin essential chain.alcineurin.ecoverin.eurocalcin).lasmodial-specific CaII-binding protein Cbp40.enta-EF-Hand proteins (sorcin.rancalcin.alpain).s well as multidomain proteins such as phosphoinositide-specific phospholipase C.ystrophin.b1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.
  IPR011992:EF-Hand type
IPR000433:ZnF_ZZ 
Evalue:-14.8860566476932 
Location:237-282IPR011992:EF-Hand_type 
Evalue:0 
Location:144-220
SequencesProtein: DTNB_HUMAN (627 aa)
mRNA: NM_021907
Local Annotation
Synapse Ontology
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 104 residues, 25453615-25453926Exon2: 13 residues, 25455662-25455696Exon3: 20 residues, 25460208-25460262Exon4: 32 residues, 25463661-25463751Exon5: 55 residues, 25464574-25464734Exon6: 9 residues, 25495887-25495908Exon7: 34 residues, 25503907-25504004Exon8: 40 residues, 25509258-25509372Exon9: 30 residues, 25510282-25510368Exon10: 31 residues, 25527920-25528008Exon11: 32 residues, 25531777-25531867Exon12: 28 residues, 25559168-25559246Exon13: 43 residues, 25607845-25607970Exon14: 57 residues, 25653210-25653377Exon15: 37 residues, 25657093-25657199Exon16: 53 residues, 25672458-25672613Exon17: 30 residues, 25683608-25683694Exon18: 73 residues, 25704543-25704757Exon19: 29 residues, 25715386-25715467Exon20: 24 residues, 25728966-25729034Exon21: 85 residues, 25749758-25750007Exon22: 2 residues, -Jump to DTNB_HUMAN  
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