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0DSG3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDSG3
DescriptionDesmoglein-3 precursor (130 kda pemphigus vulgaris antigen) (pva).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Cadherins are a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in all solid tissues of the organism which modulate a wide variety of processes including cell polarisation and migration . Cadherin-mediated cell-cell junctions are formed as a result of interaction between extracellular domains of identical cadherins.hich are located on the membranes of the neighbouring cells. The stability of these adhesive junctions is ensured by binding of the intracellular cadherin domain with the actin cytoskeleton. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changes involving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing. Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins.Structurally.adherins comprise a number of domains: classically.hese include a signal sequence; a propeptide of around 130 residues; a single transmembrane domain and five tandemly repeated extracellular cadherin domains. of which are cadherin repeats.nd the fifth contains 4 conserved cysteines and a N-terminal cytoplasmic domain . However.roteins are designated as members of the broadly defined cadherin family if they have one or more cadherin repeats. A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE.XNDNAPXF.nd DXD. Crystal structures have revealed that multiple cadherin domains form Ca2+-dependent rod-like structures with a conserved Ca2+-binding pocket at thedomain-domain interface. Cadherins depend on calcium for their function: calcium ions bind to specific residues in each cadherin repeat to ensure its proper folding.o confer rigidity upon the extracellular domain and is essential for cadherin adhesive function and for protection against protease digestion.
  IPR002126:Cadherin
Cadherins.irst discovered in mouse teratocarcinoma cells .re structurally and functionally similar molecules that take part in selective calcium-dependent adhesion interactions between cell surfaces. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changesinvolving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing.Structurally.adherins comprise a number of domains: these include asignal sequence; a propeptide of ~130 residues; an extracellular domain of~600 residues; a single transmembrane (TM) domain; and a well-conservedC-terminal cytoplasmic domain of ~150 residues. The extracellular domain can be subdivided into 5 parts. of which are repeats of ~110 residues.nd the fifth contains 4 conserved cysteines. The calcium-binding regionof cadherins is thought to be located in the extracellular domain.Desmosomes are localised junctions that hold cells tightly together.ommon in tissues subject to mechanical strain (e.g..pithelia). Desmosomal cadherins are TM protein components of desmosomes (for review.ee ).hose extracellular cadherin repeats are responsible for adhesion and whoseintracellular regions interact with intermediate filaments via desmosomalplaque proteins plakoglobin.lakobilin and desmoplakin. They are believed to play a wider role in regulation of epithelial differentiation. Two sub-families of desmosomal cadherin have been identified.esmocollin (DSC) and desmoglein (DSG).
  IPR009122:Desmosomal cadherin
Cadherins.irst discovered in mouse teratocarcinoma cells .re structurally and functionally similar molecules that take part in selective calcium-dependent adhesion interactions between cell surfaces. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of organisms. Cells containing different cadherins tend to segregate in vitro.hile those that contain the same cadherins tend to preferentially aggregate together. This observation is linked to the finding that cadherin expression causes morphological changesinvolving the positional segregation of cells into layers.uggesting they may play an important role in the sorting of different cell types during morphogenesis.istogenesis and regeneration. They may also be involved in the regulation of tight and gap junctions.nd in the control of intercellular spacing.Structurally.adherins comprise a number of domains: these include asignal sequence; a propeptide of ~130 residues; an extracellular domain of~600 residues; a single transmembrane (TM) domain; and a well-conservedC-terminal cytoplasmic domain of ~150 residues. The extracellular domain can be subdivided into 5 parts. of which are repeats of ~110 residues.nd the fifth contains 4 conserved cysteines. The calcium-binding regionof cadherins is thought to be located in the extracellular domain.Desmosomes are localised junctions that hold cells tightly together.ommon in tissues subject to mechanical strain (e.g..pithelia). Desmosomal cadherins are TM protein components of desmosomes (for review.ee ).hose extracellular cadherin repeats are responsible for adhesion and whoseintracellular regions interact with intermediate filaments via desmosomalplaque proteins plakoglobin.lakobilin and desmoplakin. They are believed to play a wider role in regulation of epithelial differentiation. Two sub-families of desmosomal cadherin have been identified.esmocollin (DSC) and desmoglein (DSG). For each subfamily.hree subtypes have been identified.xpressed in acell-type and differentiation-specific manner. Studies in normally desmosome-free cells have shown that expression of at least one DSC and one DSG in combination with plakoglobin is required to promote adhesion .Little is known about functional differences between the DSG or DSC sub- families. In sequence.owever.SG differs from DSC in having a longercytoplasmic region containing DSG repeats. Desmogleins have been implicated in autoimmune blistering skin lesion diseases. DSG1 has been shown to be a target antigen in pemphigus foliaceous.nd DSG3 in pemphigus vulgaris . DSG1 is also the target of the Staphylococcus aureus blister-causing toxin A. Mutations in DSG1resulting in reduced levels or extracellularly truncated proteinsare the cause of hepatokeratotic bands on palms and soles. dominant inherited disease termed palmoplantar keratoderma .
  IPR009123:Desmoglein
IPR002126:Cadherin 
Evalue:-31.8860569000244 
Location:272-375IPR002126:Cadherin 
Evalue:-22.2076091766357 
Location:162-258IPR002126:CA 
Evalue:-10.5086383061657 
Location:70-155IPR002126:CA 
Evalue:-10.3467874862247 
Location:409-493IPR009123:DESMOGLEIN 
Evalue:0 
Location:805-821IPR009123:DESMOGLEIN 
Evalue:0 
Location:775-789IPR009123:DESMOGLEIN 
Evalue:0 
Location:790-804IPR009123:DESMOGLEIN 
Evalue:0 
Location:825-839IPR009122:DESMOCADHERN 
Evalue:0 
Location:851-862
SequencesProtein: DSG3_HUMAN (999 aa)
mRNA: NM_001944
Local Annotation
Synapse Ontology
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
sdb:0033 regulation of synapse structure  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
KO assignmentK07598
  Level 3 annotation:
    desmoglein 3
  Level 2 annotation:
    Membrane and intracellular structural molecules
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 44 residues, 27281755-27281886Exon2: 14 residues, 27290400-27290436Exon3: 46 residues, 27290953-27291085Exon4: 54 residues, 27292405-27292561Exon5: 50 residues, 27292993-27293138Exon6: 57 residues, 27293805-27293972Exon7: 45 residues, 27294793-27294922Exon8: 64 residues, 27295187-27295373Exon9: 92 residues, 27298071-27298343Exon10: 48 residues, 27299278-27299418Exon11: 77 residues, 27300490-27300715Exon12: 89 residues, 27303049-27303310Exon13: 48 residues, 27306244-27306384Exon14: 23 residues, 27306685-27306749Exon15: 96 residues, 27308081-27308365Exon16: 291 residues, 27309606-27310474Exon17: 2 residues, -Jump to DSG3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3060 27210737-27247877 ~-37K 17168(DSG4)(+)Loci: 3061 27281755-27310474 ~-29K 17170(DSG3)(+)Loci: 4335 26900004-26936375 ~-36K 17162(DSC2)(-)Link out to UCSC