SynDB Home Page
SynDB Home Page
Browse
Search
Download
Help
People
links

blue bulletSynDB protein details  


Parse error: syntax error, unexpected T_VARIABLE in /home/kongl/syndb/www/sdb_nats.php on line 52
0DREB_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDBN1
DescriptionDrebrin (developmentally regulated brain protein).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0042641 actomyosin (NAS)
0005737 cytoplasm (NAS)
0030425 dendrite (NAS)
0003779 actin binding (NAS)
0005522 profilin binding (ISS)
0007015 actin filament organization (ISS)
0050773 regulation of dendrite morphogenesis (NAS)
0048168 regulation of neuronal synaptic plasticity (NAS)

Warning: fopen(/home/kongl/syndb/www/temp/1595755504.dot) [function.fopen]: failed to open stream: Permission denied in /home/kongl/syndb/www/sdb_pro.php on line 269

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 270

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 271

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 272

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 273

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 274

Warning: fwrite(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 299

Warning: fclose(): supplied argument is not a valid stream resource in /home/kongl/syndb/www/sdb_pro.php on line 300
schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The ADF/cofilins are a family of actin-binding proteins expressed in all eukaryotic cells so far examined. Members of this family remodel the actin cytoskeleton.or example during cytokinesis.hen the actin-rich contractile ring shrinks as it contracts through the interaction of ADF/cofilins with both monomeric and filamentous actin. ADF/cofilins sever actin filaments (F-actin) and/or bind to actin monomers.r G-actin.hus preventing actin-polymerization by sequestering the monomers. The ADF/cofilins are formed by a single folded domain.he ADF homology domain.hich is also found in other actin-binding protein families and is the most conserved region of these proteins consisting of a twenty amino-acid segment that ends some 30 residues from their C-terminal extremity . The main actin-binding structure being a long alpha-helix. Plants and animals have multiple ADF/cofilin genes.elonging in vertebrates to two types.DF and cofilins. Other eukaryotes (such as yeast.canthamoeba and slime moulds) have a single ADF/cofilin gene. The following proteins are evolutionary related and belong to a family of low molecular weight (137 to 166 residues) actin-depolymerizing proteins .Cofilin from vertebrates.lime mold and yeast. Cofilin binds to F-actin and acts as a pH-dependent actin-depolymerizing protein.Destrin from vertebrates. Destrin binds to G-actin in a pH-independent manner and prevents polymerization.Caenorhabditis elegans unc-60.Acanthamoeba castellanii actophorin.Plants actin depolymerizing factor (ADF).
  IPR002108:Actin-binding, cofilin/tropomyosin type
IPR002108:Cofilin_ADF 
Evalue:-30.2006587982178 
Location:10-133
SequencesProtein: DREB_HUMAN (648 aa)
mRNA: NM_004395
Local Annotation
Synapse Ontology
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 298 residues, 176816219-176817110Exon2: 36 residues, 176817261-176817364Exon3: 218 residues, 176817664-176818314Exon4: 59 residues, 176818704-176818875Exon5: 43 residues, 176820038-176820162Exon6: 22 residues, 176820250-176820310Exon7: 23 residues, 176826378-176826442Exon8: 52 residues, 176826517-176826669Exon9: 28 residues, 176826861-176826939Exon10: 51 residues, 176827087-176827234Exon11: 27 residues, 176827349-176827424Exon12: 39 residues, 176827714-176827827Exon13: 20 residues, 176828450-176828506Exon14: 78 residues, 176833042-176833271Exon15: 2 residues, -Jump to DREB_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 4757 176660813-176663311 ~-2K 30017(RAB24)(-)Loci: 4758 176816219-176833271 ~-17K 30039(DBN1)(-)Loci: 3512 176493531-176655367 ~-162K 30012(NSD1)(+)Link out to UCSC