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0DRD5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDRD5
DescriptionD(1b) dopamine receptor (d(5) dopamine receptor) (d1beta dopamine receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0004952 dopamine receptor activity (TAS)
0007191 dopamine receptor, adenylate cyclase activa... (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.
  IPR000929:Dopamine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G protein coupling.igand specificity.natomicaldistribution and physiological effects.D1 receptors are found in greatest abundance in the caudate-putamen.ucleus accumbens and olfactory tubercle.ith lower levels in the frontalcortex.abenula.mygdala.ypothalamus and thalamus. In the periphery.inding sites are found in the kidney.eart.iver and parathyroid gland. The receptors stimulate adenylyl cyclase through G proteins; they may alsobe able to stimulate phosphoinositide metabolism .
  IPR000497:Dopamine 1B receptor
IPR000276:7tm_1 
Evalue:-95.7447280883789 
Location:57-359IPR000497:DOPAMINED1BR 
Evalue:0 
Location:402-418IPR000929:DOPAMINER 
Evalue:0 
Location:360-374IPR000497:DOPAMINED1BR 
Evalue:0 
Location:40-53IPR000497:DOPAMINED1BR 
Evalue:0 
Location:382-390
SequencesProtein: DRD5_HUMAN (477 aa)
mRNA: NM_000798
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK05840
  Level 3 annotation:
    dopamine receptor D5
  Level 2 annotation:
    Calcium signaling pathway
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 677 residues, 9392700-9394730Exon2: 2 residues, -Jump to DRD5_HUMAN  
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