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0DRD4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDRD4
DescriptionD(4) dopamine receptor (d(2c) dopamine receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004952 dopamine receptor activity (TAS)
0007166 cell surface receptor linked signal transdu... (TAS)
0007212 dopamine receptor signaling pathway (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.
  IPR000929:Dopamine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.D4 receptors have a similar pharmacological profile to D2 receptors. Theyare expressed in the brain.redominantly in the medulla.mgdala.idbrainand frontal cortex; lower levels are found in the striatum and olfactorytubercle. D4 receptor mRNA has also been detected in peripheral tissues.nd the protein appears to be expressed preferentially in the cardiovascularsystem in the rat. They inhibit adenylyl cyclase through a pertussis-toxin-sensitive G-protein.robably belonging to the Gi/Go class .D4 subfamily may include fragments.hich the parent.opamine receptor family.oes not.
  IPR002185:Dopamine D4 receptor
IPR000276:7tm_1 
Evalue:-78.1938171386719 
Location:51-448IPR002185:DOPAMINED4R 
Evalue:0 
Location:29-46IPR000929:DOPAMINER 
Evalue:0 
Location:450-464
SequencesProtein: DRD4_HUMAN (467 aa)
mRNA: NM_000797
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 96 residues, 627304-627589Exon2: 39 residues, 629432-629545Exon3: 221 residues, 629647-630306Exon4: 103 residues, 630400-630703Exon5: 2 residues, -Jump to DRD4_HUMAN  
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Loci Cluster (Details)Loci: 2642 627304-630703 ~-3K 6078(DRD4)(+)Loci: 3928 780475-786221 ~-6K 6091(SLC25A22)(-)Loci: 3929 789178-795245 ~-6K 6092(-)Loci: 2643 915840-1002239 ~-86K 6112(AP2A2)(+)Loci: 3927 192923-197383 ~-4K 6029(-)Link out to UCSC