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0DRD3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDRD3
DescriptionD(3) dopamine receptor.
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005886 plasma membrane (TAS)
0004952 dopamine receptor activity (TAS)
0007610 behavior (TAS)
0007212 dopamine receptor signaling pathway (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.
  IPR000929:Dopamine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.D3 receptors have a similar pharmacological profile to D2 receptors. Theyare expressed predominantly in the limbic area (including the olfactorytubercle.ucleus accumbens.slands of Calleja and hypothalamus).nd theyare present in lower levels in the caudate-putamen and cerebral cortex.The receptors are also found in dopamine cell bodies in the substantianigra. The distribution of the receptors is consistent with a role incognition and emotional functions; they may thus be the target of antipsychotic therapy involving dopamine antagonists .
  IPR001620:Dopamine D3 receptor
IPR000276:7tm_1 
Evalue:-86.1674880981445 
Location:46-383IPR001620:DOPAMINED3R 
Evalue:0 
Location:10-29IPR000929:DOPAMINER 
Evalue:0 
Location:385-399
SequencesProtein: DRD3_HUMAN (400 aa)
mRNA: NM_000796
Local Annotation
Synapse Ontology
?
sdb:0219 GPCR mediated signaling  (Evidence:domains)
KO assignmentK04146
  Level 3 annotation:
    dopamine receptor D3
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 68 residues, 115330246-115330449Exon2: 96 residues, 115332654-115332937Exon3: 67 residues, 115341036-115341233Exon4: 49 residues, 115348951-115349094Exon5: 39 residues, 115361291-115361404Exon6: 103 residues, 115373259-115373563Exon7: 86 residues, 115380193-115380446Exon8: 2 residues, -Jump to DRD3_HUMAN  
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