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0DRD2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDRD2
DescriptionD(2) dopamine receptor (dopamine d2 receptor).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005887 integral to plasma membrane (TAS)
0005882 intermediate filament (TAS)
0005886 plasma membrane (TAS)
0004952 dopamine receptor activity (TAS)
0004888 transmembrane receptor activity (TAS)
0007195 dopamine receptor, adenylate cyclase inhibi... (TAS)
0007399 neurogenesis (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains assigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.
  IPR000929:Dopamine receptor
InterPro domains unassigned to SynO:
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .
  IPR000276:Rhodopsin-like GPCR superfamily
G-protein-coupled receptors.PCRs.onstitute a vast protein family that encompasses a wide range of functions (including various autocrine.aracrine and endocrine processes). They show considerable diversity at the sequence level.n the basis of which they can be separated into distinct groups. We use the term clan to describe the GPCRs.s they embrace a group of families for which there are indications of evolutionary relationship.ut between which there is no statistically significant similarity in sequence . The currently known clan members include the rhodopsin-like GPCRs.he secretin-like GPCRs.he cAMP receptors.he fungal mating pheromone receptors.nd the metabotropic glutamate receptor family. There is a specialized database for GPCRs: http://www.gpcr.org/7tm/. The rhodopsin-like GPCRs themselves represent a widespread protein family that includes hormone.eurotransmitter and light receptors.ll of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. Although their activating ligands vary widely in structure and character.he amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7transmembrane (TM) helices .Dopamine neurons in the vertebrate central nervous system are involved inthe initiation and execution of movement.he maintenance of emotionalstability.nd the regulation of pituitary function . Various humanneurological diseases (e.g..arkinson disease and schizophrenia).rebelieved to be manifestations of dopamine and dopamine receptor imbalance.The receptors have been divided into several different subtypes.istinguished by their G-protein coupling.igand specificity.natomicaldistribution and physiological effects.D2 receptors have a similar pharmacological profile to D3 and D4 receptors.They are present in high levels in the principal dopamine projection areas(including the caudate-putamen.ucleus accumbens and olfactory tubercle);they are found in cell bodies of dopaminergic neurons in the substantianigra and ventral tegmental area; and.n the periphery.hey are found inthe pituitary.eart and blood vessels .
  IPR001922:Dopamine D2 receptor
IPR000276:7tm_1 
Evalue:-101.443695068359 
Location:51-426IPR000929:DOPAMINER 
Evalue:0 
Location:428-442IPR001922:DOPAMINED2R 
Evalue:0 
Location:2-13
SequencesProtein: DRD2_HUMAN (443 aa)
mRNA: AB209832 AF176812 NM_000795
Local Annotation
Synapse Ontology
intermediate filaments of the presynaptic compartments. Both microtubles and intermediate filaments represent the main structural scaffold of axons.
sdb:0086 intermediate filaments  (Evidence:keywords,domains)
Typical ecretory organelles, some 50 nm in diameter, of presynaptic nerve terminals; accumulate high concentrations of nonpeptide neurotransmitters and secrete these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
sdb:0094 typical synaptic vesicle  (Evidence:keywords,domains)
Various stages of the synaptic vesicle cycle, including attachment, prefusion, triggering, recycling and reloading of the vesicles with transmitter.
sdb:0098 synaptic vesicle cycling  (Evidence:keywords,domains)
?
sdb:0219 GPCR mediated signaling  (Evidence:keywords,domains)
KO assignmentK04145
  Level 3 annotation:
    dopamine receptor D2
  Level 2 annotation:
    G-protein coupled receptors
    Neuroactive ligand-receptor interaction
    Gap junction
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 442 residues, 112785527-112786852Exon2: 111 residues, 112788487-112788815Exon3: 31 residues, 112790306-112790393Exon4: 65 residues, 112791352-112791543Exon5: 47 residues, 112792794-112792931Exon6: 38 residues, 112793958-112794068Exon7: 107 residues, 112800298-112800614Exon8: 30 residues, 112851007-112851091Exon9: 2 residues, -Jump to DRD2_HUMANExon1: 436 residues, 112785547-112786852Exon2: 111 residues, 112788487-112788815Exon3: 31 residues, 112790306-112790393Exon4: 65 residues, 112791352-112791543Exon5: 47 residues, 112792794-112792931Exon6: 36 residues, 112793958-112794061Exon7: 109 residues, 112800294-112800616Exon8: 2 residues, -Jump to DRD2_HUMANExon1: 117 residues, 112786504-112786852Exon2: 113 residues, 112788487-112788821Exon3: 31 residues, 112790306-112790393Exon4: 65 residues, 112791352-112791543Exon5: 47 residues, 112792794-112792931Exon6: 38 residues, 112793958-112794068Exon7: 100 residues, 112800298-112800592Exon8: 2 residues, -Jump to DRD2_HUMAN  
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Loci Cluster (Details)Loci: 3992 113063482-113082305 ~-19K 7767(TMPRSS5)(-)Loci: 3993 113109120-113149635 ~-41K 7769(ZW10)(-)Loci: 2706 113280798-113322492 ~-42K 7774(+)Loci: 2707 113351119-113366242 ~-15K 7775(HTR3A)(+)Loci: 2708 113435640-113626604 ~-191K 7782(ZBTB16)(+)Loci: 3991 112785527-112851091 ~-66K 7762(DRD2)(-)Link out to UCSC