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0DPOG1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePOLG
DescriptionDna polymerase gamma subunit 1 (ec 2.7.7.7) (mitochondrial dna polymerase catalytic subunit) (polg-alpha).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005739 mitochondrion (TAS)
0003891 delta DNA polymerase activity (TAS)
0003895 gamma DNA-directed DNA polymerase activity (TAS)
0006259 DNA metabolism (TAS)
0006261 DNA-dependent DNA replication (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Synonym(s): DNA nucleotidyltransferase (DNA-directed) DNA-directed DNA polymerases() are the key enzymes catalyzing theaccurate replication of DNA. They require either a small RNA molecule or aprotein as a primer for the de novo synthesis of a DNA chain. A number ofpolymerases belong to this family.
  IPR001098:DNA-directed DNA polymerase
DNA carries the biological information that instructs cells how to existin an ordered fashion. Accurate replication is thus one of the mostimportant events in the cell life cycle. This function is mediated byDNA-directed DNA-polymerases.hich add nucleotide triphosphate (dNTP)residues to the 5-end of the growing DNA chain.sing a complementary DNA as template. Small RNA molecules are generally used as primers forchain elongation.lthough terminal proteins may also be used.DNA-dependent DNA-polymerases have been grouped into families.enoted A.and X.n the basis of sequence similarities . Members of family A.hich includes bacterial and bacteriophage polymerases.hare significantsimilarity to Escherichia coli polymerase I; hence family A is also known as the pol Ifamily. The bacterial polymerases also contain an exonuclease activity.hich is coded for in the N-terminal portion. The yeast gamma polymerasesshow some similarity to the prokaryotic nuclear polymerases of family A.ut their function is restricted to mitochondrial DNA replication and repair .Three motifs.. and C.s defined by Delarue et al. .re seen to be conserved across all DNA-polymerases.ith motifs A and C also seen in RNA- polymerases. They are centered on invariant residues.nd their structural significance was implied from the Klenow (E. coli) structure. Motif A contains a strictly-conserved aspartate at the junction of a beta-strand and an alpha-helix; motif B contains an alpha-helix with positive charges; and motif C has a doublet of negative charges.ocated in a beta-turn-beta secondary structure .
  IPR002297:DNA-polymerase gamma A
The catalytic domain of several polynucleotidyl transferases share a similar structure.onsisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets.uggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII).IV RNase (reverse transcriptase domain).etroviral integrase (catalytic domain).u transposase (core domain).ransposase inhibitor Tn5 (containing additional all-alpha subdomains).naQ-like 3-5 exonucleases (exonuclease domains).uvC resolvase.nd mitochondrial resolvase ydc2 (catalytic domain) .
  IPR012337:Polynucleotidyl transferase, Ribonuclease H fold
IPR001098:DNA_pol_A 
Evalue:-243.420211791992 
Location:730-1182IPR002297:DNA_polG 
Evalue:0 
Location:158-705IPR002297:DNAPOLG 
Evalue:0 
Location:127-139
SequencesProtein: DPOG1_HUMAN (1239 aa)
mRNA: NM_002693
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK02332
  Level 3 annotation:
    DNA polymerase gamma subunit
  Level 2 annotation:
    DNA polymerase
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 167 residues, 87660562-87661062Exon2: 55 residues, 87661610-87661771Exon3: 71 residues, 87662775-87662984Exon4: 58 residues, 87663165-87663334Exon5: 43 residues, 87663462-87663585Exon6: 84 residues, 87665000-87665247Exon7: 47 residues, 87665359-87665495Exon8: 41 residues, 87665970-87666088Exon9: 20 residues, 87666196-87666250Exon10: 55 residues, 87666976-87667137Exon11: 38 residues, 87667638-87667746Exon12: 31 residues, 87668049-87668136Exon13: 42 residues, 87668341-87668462Exon14: 81 residues, 87669684-87669921Exon15: 44 residues, 87670846-87670973Exon16: 52 residues, 87671146-87671298Exon17: 63 residues, 87671401-87671584Exon18: 28 residues, 87672690-87672770Exon19: 51 residues, 87672919-87673066Exon20: 58 residues, 87673177-87673345Exon21: 67 residues, 87674315-87674511Exon22: 274 residues, 87677330-87678148Exon23: 43 residues, 87678907-87679030Exon24: 2 residues, -Jump to DPOG1_HUMAN  
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Loci Cluster (Details)Loci: 4193 88008602-88023595 ~-15K 12995(PLIN)(-)Loci: 4194 88129129-88150938 ~-22K 13000(ANPEP)(-)Loci: 4195 88177792-88238206 ~-60K 13001(AP3S2)(-)Loci: 2905 88609898-88616447 ~-7K 13015(+)Loci: 4196 88691822-88693673 ~-2K 13016(GABARAPL3)(-)Loci: 2906 88732476-88846479 ~-114K 13020(IQGAP1)(+)Loci: 4192 87660562-87679030 ~-18K 12989(POLG)(-)Link out to UCSC