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0DPOE1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NamePOLE
DescriptionDna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0003677 DNA binding (TAS)
0005515 protein binding (IPI)
0006260 DNA replication (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This domain is found on the epsilon catalytic subunit of DNA polymerase. It is foundC-terminal to and .
  IPR013697:Domain of unknown function DUF1744
DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases ) by adding nucleotide triphosphate (dNTP) residues to the 5-end of the growing chain of DNA.sing a complementary DNA chain as a template. Small RNA molecules are generally used as primers for chain elongation.lthough terminal proteins may also be used for the de novo synthesis of a DNA chain. Even though there are 2 different methods of priming.hese are mediated by 2 very similar polymerases classes. and B.ith similar methods of chain elongation. A number of DNA polymerases have been grouped under the designation of DNA polymerase family B. Six regions of similarity (numbered from I to VI) are found in all or a subset of the B family polymerases. The most conserved region (I) includes a conserved tetrapeptide with two aspartate residues. Its function is not yet known. However.t has been suggested that it may be involved in binding a magnesium ion. All sequences in the B family contain a characteristic DTDS motif.nd possess many functional domains.ncluding a 5-3 elongation domain. 3-5 exonuclease domain . DNA binding domain.nd binding domains for both dNTPs and pyrophosphate . This domain has 3 to 5 exonuclease activity and adopts a ribonuclease H type fold .
  IPR006133:DNA polymerase B, exonuclease
DNA is the biological information that instructs cells how to exist in anordered fashion: accurate replication is thus one of the most importantevents in the life cycle of a cell. This function is performed by DNA-directed DNA-polymerases () by adding nucleotide triphosphate (dNTP) residues to the 5-end of the growing chain of DNA.sing a complementary DNA chain as a template. Small RNA molecules are generally used as primers for chain elongation.lthough terminal proteins may also be used for the de novo synthesis of a DNA chain. Even though there are 2 different methods of priming.hese are mediated by 2 very similar polymerases classes. and B.ith similar methods of chain elongation. A number of DNA polymerases have been groupedunder the designation of DNA polymerase family B.Six regions of similarity (numbered from I to VI) are found in all or a subsetof the B family polymerases. The most conserved region (I) includes a conservedtetrapeptide with two aspartate residues. Its function is not yet known.However.t has been suggested that it may be involved in binding amagnesium ion. All sequences in the Bfamily contain a characteristic DTDS motif.nd possess many functionaldomains.ncluding a 5-3 elongation domain. 3-5 exonuclease domain . DNA binding domain.nd binding domains for both dNTPs and pyrophosphate .
  IPR006172:DNA-directed DNA polymerase B
DNA is the biological information that instructs cells how to exist in an ordered fashion: accurate replication is thus one of the most important events in the life cycle of a cell. This function is performed by DNA- directed DNA-polymerases ) by adding nucleotide triphosphate (dNTP) residues to the 5-end of the growing chain of DNA.sing a complementary DNA chain as a template. Small RNA molecules are generally used as primers for chain elongation.lthough terminal proteins may also be used for the de novo synthesis of a DNA chain. Even though there are 2 different methods of priming.hese are mediated by 2 very similar polymerases classes. and B.ith similar methods of chain elongation. A number of DNA polymerases have been grouped under the designation of DNA polymerase family B. Six regions of similarity (numbered from I to VI) are found in all or a subset of the B family polymerases. The most conserved region (I) includes a conserved tetrapeptide with two aspartate residues. Its function is not yet known.owever.t has been suggested that it may be involved in binding a magnesium ion. All sequences in the B family contain a characteristic DTDS motif.nd possess many functional domains.ncluding a 5-3 elongation domain. 3-5 exonuclease domain . DNA binding domain.nd binding domains for both dNTPs and pyrophosphate . This region of DNA polymerase B appears to consist of more than one structural domain.ossibly including elongation.NA-binding and dNTP binding activities .
  IPR006134:DNA polymerase B region
The catalytic domain of several polynucleotidyl transferases share a similar structure.onsisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets.uggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII).IV RNase (reverse transcriptase domain).etroviral integrase (catalytic domain).u transposase (core domain).ransposase inhibitor Tn5 (containing additional all-alpha subdomains).naQ-like 3-5 exonucleases (exonuclease domains).uvC resolvase.nd mitochondrial resolvase ydc2 (catalytic domain) .
  IPR012337:Polynucleotidyl transferase, Ribonuclease H fold
IPR013697:DUF1744 
Evalue:-249.853866577148 
Location:1525-1925IPR006133:DNA_pol_B_exo 
Evalue:-134.468521118164 
Location:86-427IPR006134:DNA_pol_B 
Evalue:-4.58502674102783 
Location:496-1161
SequencesProtein: DPOE1_HUMAN (2286 aa)
mRNA: NM_006231
Local Annotation
Synapse Ontology
attachment of the vesicle filled with transmitters involves a specific interaction between the vesicle membrane and the presynaptic active zone.
sdb:0148 docking  (Evidence:keywords)
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK02324
  Level 3 annotation:
    DNA polymerase epsilon, subunit A
  Level 2 annotation:
    DNA polymerase
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 350 residues, 131710420-131711469Exon2: 32 residues, 131711563-131711653Exon3: 44 residues, 131712303-131712429Exon4: 69 residues, 131712775-131712976Exon5: 66 residues, 131718973-131719167Exon6: 46 residues, 131719322-131719454Exon7: 66 residues, 131720844-131721037Exon8: 46 residues, 131722550-131722683Exon9: 44 residues, 131724672-131724798Exon10: 60 residues, 131725783-131725957Exon11: 70 residues, 131728305-131728510Exon12: 75 residues, 131728835-131729056Exon13: 76 residues, 131729164-131729388Exon14: 61 residues, 131729478-131729655Exon15: 37 residues, 131729882-131729989Exon16: 53 residues, 131730065-131730219Exon17: 49 residues, 131730495-131730636Exon18: 50 residues, 131735587-131735731Exon19: 72 residues, 131735964-131736174Exon20: 73 residues, 131736335-131736548Exon21: 43 residues, 131743794-131743917Exon22: 29 residues, 131744007-131744088Exon23: 36 residues, 131744526-131744629Exon24: 73 residues, 131745953-131746168Exon25: 67 residues, 131747627-131747823Exon26: 54 residues, 131748185-131748343Exon27: 50 residues, 131750662-131750807Exon28: 33 residues, 131751028-131751121Exon29: 51 residues, 131751960-131752109Exon30: 50 residues, 131754161-131754307Exon31: 51 residues, 131755014-131755161Exon32: 36 residues, 131755293-131755396Exon33: 45 residues, 131755469-131755598Exon34: 38 residues, 131758873-131758981Exon35: 73 residues, 131759285-131759498Exon36: 40 residues, 131759822-131759936Exon37: 46 residues, 131760233-131760366Exon38: 42 residues, 131762056-131762176Exon39: 30 residues, 131762393-131762479Exon40: 39 residues, 131762752-131762863Exon41: 38 residues, 131763204-131763312Exon42: 29 residues, 131764021-131764102Exon43: 49 residues, 131764236-131764378Exon44: 53 residues, 131766155-131766310Exon45: 33 residues, 131766612-131766705Exon46: 17 residues, 131766836-131766881Exon47: 29 residues, 131767265-131767346Exon48: 49 residues, 131767796-131767938Exon49: 37 residues, 131773912-131774018Exon50: 2 residues, -Jump to DPOE1_HUMAN  
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