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0DNJC5_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
DescriptionDnaj homolog subfamily c member 5 (cysteine string protein) (csp).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The prokaryotic heat shock protein DnaJ interacts with the chaperone hsp70-like DnaK protein . Structurally.he DnaJ protein consists of an N-terminal conserved domain (called J domain) of about 70 amino acids. glycine-rich region (G domain) of about 30 residues. central domain containing four repeats of a CXXCXGXG motif (CRR domain) and a C-terminal region of 120 to 170 residues.Such a structure is shown in the following schematic representation:It is thought that the J domain of DnaJ mediates the interaction with the dnaK protein and consists of four helices.he second of which has a charged surface that includes at least one pair of basic residues that are essential for interaction with the ATPase domain of Hsp70. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins .ither together or separately. In yeast.-domains have been classified into 3 groups; the class III proteins are functionally distinct and do not appear to act as molecular chaperones .
  IPR001623:Heat shock protein DnaJ, N-terminal
Molecular chaperones are a diverse family of proteins that function to protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. The bacterial molecular chaperone DnaK is an enzyme that couples cycles of ATP binding.ydrolysis.nd ADP release by an N-terminal ATP-hydrolizing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. Dimeric GrpE is the co-chaperone for DnaK.nd acts as a nucleotide exchange factor.timulating the rate of ADP release 5000-fold . DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone.naJ. Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate-bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle.Besides stimulating the ATPase activity of DnaK through its J-domain.naJ also associates with unfolded polypeptide chains and prevents their aggregation . Thus.naK and DnaJ may bind to one and the same polypeptide chain to form a ternary complex. The formation of a ternary complex may result in cis-interaction of the J-domain of DnaJ with the ATPase domain of DnaK. An unfolded polypeptide may enter the chaperone cycle by associating first either with ATP-liganded DnaK or with DnaJ. DnaK interacts with both the backbone and side chains of a peptide substrate; it thus shows binding polarity and admits only L-peptide segments. In contrast.naJ has been shown to bind both L- and D-peptides and is assumed to interact only with the side chains of the substrate.DnaJ comprises a 70-residue N-terminal domain (the J-domain); a 30-residue glycine-rich region (the G-domain); a central domain containing 4 repeats of a CxxCxGxG motif (the CRR-domain); and a 120-170 residue C-terminal region. The J- and CRR-domains are found in many prokaryotic and eukaryotic proteins .ither together or separately.
  IPR003095:Heat shock protein DnaJ
SequencesProtein: DNJC5_HUMAN (198 aa)
mRNA: NM_025219
Local Annotation
Synapse Ontology
sdb:0004 Presynaptic compartment  (Evidence:keywords)
The membrane surrounding a synaptic vesicle.
sdb:0077 synaptic vesicle membrane  (Evidence:keywords)
sdb:0223 transmitter release  (Evidence:keywords)
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 54 residues, 61996961-61997120Exon2: 41 residues, 62030131-62030249Exon3: 73 residues, 62031108-62031322Exon4: 59 residues, 62032647-62032819Exon5: 861 residues, 62033261-62035838Exon6: 2 residues, -Jump to DNJC5_HUMAN  
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Loci Cluster (Details)Loci: 3279 60906621-60915796 ~-9K 23505(OGFR)(+)Loci: 3280 61337720-61342298 ~-5K 23526(BIRC7)(+)Loci: 4537 61448389-61463100 ~-15K 23536(CHRNA4)(-)Loci: 4538 61507985-61574437 ~-66K 23542(KCNQ2)(-)Loci: 4539 61630221-61639151 ~-9K 23549(PTK6)(-)Loci: 4540 61642606-61649301 ~-7K 23550(SRMS)(-)Loci: 4541 61659883-61676033 ~-16K 23552(PRIC285)(-)Loci: 4542 61689398-61721673 ~-32K 23556(GMEB2)(-)Loci: 3281 61996961-62035838 ~-39K 23585(DNAJC5)(+)Loci: 3282 62082900-62134895 ~-52K 23593(C20orf14)(+)Loci: 3283 62181931-62202435 ~-21K 23600(OPRL1)(+)Loci: 3278 60810633-60864567 ~-54K 23503(NTSR1)(+)Link out to UCSC