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0DMAP1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDMAP1
DescriptionDna methyltransferase 1-associated protein 1 (dnmt1-associated protein 1) (dnmap1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005634 nucleus (NAS)
0005515 protein binding (IPI)
0016564 transcriptional repressor activity (NAS)
0006306 DNA methylation (TAS)
0016481 negative regulation of transcription (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes.hich include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation.NMT1.an also establish a repressive transcription complex. The non-catalytic N terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein).nd can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity.nd binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase.hereas HDAC2 joins DNMT1 and DMAP1 only during late S phase.roviding a platform for how histones may become deacetylated in heterochromatin following replication .
  IPR008468:DNA methyltransferase 1-associated 1
The retroviral oncogene v-myb.nd its cellular counterpart c-myb.ncode nuclear DNA-binding proteins. These belong to the SANT domain family that specifically recognize the sequence YAAC(G/T)G . In myb.ne of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding .
  IPR001005:Myb, DNA-binding
IPR008468:DMAP1 
Evalue:-121.200660705566 
Location:243-407IPR001005:SANT 
Evalue:-1.48148606012211 
Location:148-201IPR001005:MYB_3 
Evalue:0 
Location:0-0
SequencesProtein: DMAP1_HUMAN (467 aa)
mRNA: NM_019100
Local Annotation
Synapse Ontology
A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
sdb:0039 positive regulation of long-term neuronal synaptic plasticity  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 136 residues, 44451711-44452117Exon2: 32 residues, 44452608-44452700Exon3: 67 residues, 44452961-44453157Exon4: 55 residues, 44456569-44456728Exon5: 58 residues, 44456846-44457014Exon6: 64 residues, 44457314-44457500Exon7: 26 residues, 44457664-44457736Exon8: 26 residues, 44458064-44458137Exon9: 99 residues, 44458275-44458568Exon10: 42 residues, 44458817-44458938Exon11: 2 residues, -Jump to DMAP1_HUMAN  
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Loci Cluster (Details)Loci: 2511 44217452-44229426 ~-12K 1299(B4GALT2)(+)Loci: 3798 44234742-44255584 ~-21K 1302(SLC6A9)(-)Loci: 2512 44451711-44458938 ~-7K 1306(DMAP1)(+)Loci: 2510 43888424-43943725 ~-55K 1275(JMJD2A)(+)Link out to UCSC