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0DLG4_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDLG4
DescriptionPostsynaptic density protein 95 (psd-95) (synapse-associated protein 90) (sap90) (discs large homolog 4).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0030863 cortical cytoskeleton (IDA)
0045211 postsynaptic membrane (IDA)
0008022 protein C-terminus binding (IPI)
0007612 learning (TAS)
0007399 neurogenesis (TAS)
0006461 protein complex assembly (TAS)
0007165 signal transduction (TAS)
0007268 synaptic transmission (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents a domain found in guanylate kinase () and in L-type calcium channel.Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel.ince they form the drug binding domain. Other properties.uch as gating voltage-dependence. protein modulation and kinase susceptibility.re influenced by alpha-2.elta and beta subunits.
  IPR008145:Guanylate kinase/L-type calcium channel region
Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain.n SH3 domain as well as a C-terminal GK-likedomain.re collectively termed MAGUKs (membrane-associated guanylate kinase homologs) .ndinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junctionprotein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail ofNMDA receptor subunits (SAP90/PSD-95.HAPSYN-110/PSD-93.AP97/DLG1 and SAP102); vertebrate 55 kD erythrocytemembrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There isan ATP-binding site (P-loop) in the N-terminal section of GK.hich is not conserved in the GK-like domain ofthe above proteins. However these proteins retain the residues known.n GK.o be involved in the binding ofGMP.
  IPR008144:Guanylate kinase
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
IPR008145:GuKc 
Evalue:-67.431798275933 
Location:533-712IPR001478:PDZ 
Evalue:-29.6989707946777 
Location:65-149IPR001478:PDZ 
Evalue:-28.1870861053467 
Location:160-244IPR001478:PDZ 
Evalue:-27.8239078521729 
Location:313-391IPR001452:SH3 
Evalue:-8.95860731484177 
Location:431-497IPR002114:PTS_HPR_SER 
Evalue:0 
Location:0-0
SequencesProtein: DLG4_HUMAN (724 aa)
mRNA: NM_001365
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
focus on function of synapse, corresponding to the structure of synapse.
sdb:0003 physiology/function at synapse  (Evidence:keywords)
all
sdb:0004 Presynaptic compartment  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
transport of vesicles in the presynaptic neuron
sdb:0017 Mobilization: synapsins, CAM kinase I  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
sdb:0035 regulation of synaptic plasticity  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
?
sdb:0297 NMDA receptor  (Evidence:keywords)
the formation of new synapse
sdb:0316 synapse formation  (Evidence:keywords)
?
sdb:0334 inhibitory postsynapstic component  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 308 residues, 7033935-7034857Exon2: 32 residues, 7035309-7035401Exon3: 38 residues, 7035935-7036045Exon4: 59 residues, 7036987-7037160Exon5: 36 residues, 7037525-7037627Exon6: 18 residues, 7037709-7037757Exon7: 11 residues, 7037886-7037914Exon8: 14 residues, 7038006-7038043Exon9: 61 residues, 7038361-7038538Exon10: 40 residues, 7040262-7040377Exon11: 36 residues, 7040515-7040618Exon12: 100 residues, 7040799-7041095Exon13: 50 residues, 7046945-7047090Exon14: 47 residues, 7047235-7047372Exon15: 58 residues, 7047466-7047636Exon16: 43 residues, 7047734-7047859Exon17: 22 residues, 7048050-7048110Exon18: 20 residues, 7048241-7048295Exon19: 24 residues, 7052216-7052282Exon20: 15 residues, 7062283-7062324Exon21: 35 residues, 7062583-7062682Exon22: 292 residues, 7062873-7063745Exon23: 2 residues, -Jump to DLG4_HUMAN  
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Loci Cluster (Details)Loci: 4258 6644024-6675784 ~-32K 14997(TEKT1)(-)Loci: 4259 7033935-7063745 ~-30K 15014(DLG4)(-)Loci: 2974 7063876-7069308 ~-5K 15016(ACADVL)(+)Loci: 4260 7084462-7086477 ~-2K 15021(GABARAP)(-)Loci: 2975 7252225-7263903 ~-12K 15047(NLGN2)(+)Loci: 2976 7289129-7301655 ~-13K 15051(CHRNB1)(+)Loci: 2977 7427889-7432228 ~-4K 15066(MPDU1)(+)Loci: 2978 7474184-7477419 ~-3K 15071(SHBG)(+)Loci: 4261 7512446-7531642 ~-19K 15074(TP53)(-)Loci: 4262 7774391-7775983 ~-2K 15094(TRAPPC1)(-)Loci: 2979 7846716-7864382 ~-18K 15097(GUCY2D)(+)Loci: 4263 8004447-8006987 ~-3K 15108(VAMP2)(-)Loci: 2980 8093361-8114528 ~-21K 15119(PFAS)(+)Loci: 2981 8279988-8330396 ~-50K 15135(+)Loci: 2973 6620295-6631688 ~-11K 14996(FBXO39)(+)Link out to UCSC