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0DLG2_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDLG2
DescriptionPostsynaptic density protein psd-93 (channel associated protein of synapse-110) (chapsyn-110) (discs large homolog 2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005886 plasma membrane (TAS)
0004385 guanylate kinase activity (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry represents a domain found in guanylate kinase () and in L-type calcium channel.Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel.ince they form the drug binding domain. Other properties.uch as gating voltage-dependence. protein modulation and kinase susceptibility.re influenced by alpha-2.elta and beta subunits.
  IPR008145:Guanylate kinase/L-type calcium channel region
Guanylate kinase () (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP.It is essential for recycling GMP and indirectly.GMP. In prokaryotes (such as Escherichia coli).ower eukaryotes(such as yeast) and in vertebrates.K is a highly conserved monomeric protein of about 200 amino acids. GKhas been shown to be structurally similar to protein A57R (or SalG2R)from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain.n SH3 domain as well as a C-terminal GK-likedomain.re collectively termed MAGUKs (membrane-associated guanylate kinase homologs) .ndinclude Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junctionprotein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail ofNMDA receptor subunits (SAP90/PSD-95.HAPSYN-110/PSD-93.AP97/DLG1 and SAP102); vertebrate 55 kD erythrocytemembrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There isan ATP-binding site (P-loop) in the N-terminal section of GK.hich is not conserved in the GK-like domain ofthe above proteins. However these proteins retain the residues known.n GK.o be involved in the binding ofGMP.
  IPR008144:Guanylate kinase
PDZ domains are found in diverse signaling proteins in bacteria.easts.lants.nsects and vertebrates . PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences . In most cases.nteraction between a PDZ domain and its target is constitutive.ith a binding affinity of 1 to 10 ┬ÁM. However.gonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane. compartment where high concentrations of phosphatidylinositol 4.-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin.ASK.iam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices. and B.ompactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
  IPR001478:PDZ/DHR/GLGF
SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues . They are found in a great variety of intracellular or membrane-associated proteins for example.n a variety of proteins with enzymatic activity.n adaptor proteins that lack catalytic sequences and in cytoskeletal proteins.uch as fodrin and yeast actin binding protein ABP-1. The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices . The surface of the SH2-domain bears a flat.ydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions.The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins.ltering their subcellular location and mediating the assembly of large multiprotein complexes .
  IPR001452:Src homology-3
Sterile alpha motif (SAM) domains are known to be involved in diverse protein-protein interactions.ssociating with both SAM-containing and non-SAM-containing proteins pathway . SAM domains exhibit a conserved structure.onsisting of a 4-5-helical bundle of two orthogonally packed alpha-hairpins. However SAM domains display a diversity of function.eing involved in interactions with proteins.NA and RNA . The name sterile alpha motif arose from its presence in proteins that are essential for yeast sexual differentiation. The SAM domain has had various names.ncluding SPM.TN (pointed).EP (yeast sterility.ts-related.cG proteins).CR (N-terminal conserved region) and HLH (helix-loop-helix) domain.ll of which are related and can be classified as SAM domains. SAM domains occur in eukaryotic and in some bacterial proteins. Structures have been determined for several proteins that contain SAM domains.ncluding Ets-1 transcription factor.hich plays a role in the development and invasion of tumour cells by regulating the expression of matrix-degrading proteases ; Etv6 transcription factor.ene rearrangements of which have been demonstrated in several malignancies ; EphA4 receptor tyrosine kinase.hich is believed to be important for the correct localization of a motoneuron pool to a specific position in the spinal cord ; EphB2 receptor.hich is involved in spine morphogenesis via intersectin.dc42 and N-Wasp ; p73. p53 homologue involved in neuronal development ; and polyhomeotic.hich is a member of the Polycomb group of genes (Pc-G) required for the maintenance of the spatial expression pattern of homeotic genes .
  IPR010993:Sterile alpha motif homology
IPR008145:GuKc 
Evalue:-70.8538719643218 
Location:679-858IPR001478:PDZ 
Evalue:-29.1366767883301 
Location:98-182IPR001478:PDZ 
Evalue:-27.1938209533691 
Location:193-277IPR001478:PDZ 
Evalue:-26.6020603179932 
Location:421-499IPR001452:SH3 
Evalue:-7.58502665202918 
Location:539-605IPR010993:SAM_homology 
Evalue:0 
Location:12-65IPR000215:SERPIN 
Evalue:0 
Location:367-377
SequencesProtein: DLG2_HUMAN (870 aa)
mRNA: NM_001364
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
Postsynaptic compartment is represented by a patch of plasma membrane containing a packed array of neurotransmitter receptors and by an underlying dense matrix, the postsynaptic density (PSD).
sdb:0005 Postsynaptic compartment  (Evidence:keywords)
The formation of a synapse.
sdb:0034 synaptogenesis  (Evidence:keywords)
the plasma membrane of the postsynaptic neuron. It apposes with presynaptic actiove zone.
sdb:0108 postsynaptic plasma membrane  (Evidence:keywords)
?
sdb:0297 NMDA receptor  (Evidence:keywords)
the formation of new synapse
sdb:0316 synapse formation  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 97 residues, 82848326-82848615Exon2: 32 residues, 82850692-82850784Exon3: 38 residues, 82855398-82855508Exon4: 59 residues, 82857891-82858064Exon5: 36 residues, 82860316-82860418Exon6: 18 residues, 82861417-82861466Exon7: 36 residues, 82872817-82872919Exon8: 27 residues, 82921398-82921474Exon9: 61 residues, 82930372-82930549Exon10: 40 residues, 83021901-83022016Exon11: 36 residues, 83175380-83175483Exon12: 54 residues, 83222304-83222461Exon13: 25 residues, 83263110-83263179Exon14: 54 residues, 83319018-83319174Exon15: 48 residues, 83351575-83351714Exon16: 50 residues, 83354014-83354159Exon17: 47 residues, 83369196-83369333Exon18: 58 residues, 83448005-83448175Exon19: 43 residues, 83487613-83487738Exon20: 19 residues, 83552151-83552202Exon21: 20 residues, 83639928-83639982Exon22: 56 residues, 83923260-83923422Exon23: 108 residues, 84311768-84312086Exon24: 2 residues, -Jump to DLG2_HUMAN