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0DICER_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDICER1
DescriptionEndoribonuclease dicer (ec 3.1.26.-) (helicase with rnase motif) (helicase-moi).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005622 intracellular (NAS)
0003725 double-stranded RNA binding (IDA)
0005515 protein binding (IPI)
0004525 ribonuclease III activity (IDA)
0030423 RNA interference, targeting of mRNA for des... (IEP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This putative domain is found in members of the Dicer protein family of dsRNA nucleases. This domain of about 100 amino acids has no known function.ut does contain 3 possible zinc ligands.
  IPR005034:Protein of unknown function DUF283
This domain is named after the proteins Piwi Argonaut and Zwille. It is also found in the CAF protein from Arabidopsis thaliana. The function of the domain is unknown but has been found in the middle region of a number of members of the Argonaute protein family.hich also contain the Piwi domain () in their C-terminal region . Several members of this family have been implicated in the development and maintenance of stem cells through the RNA-mediated gene-quelling mechanisms associated with the protein DICER.
  IPR003100:Argonaute and Dicer protein, PAZ
Prokaryotic ribonuclease III () (gene rnc) is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related to the fission yeast pac1. ribonuclease that probablyinhibits mating and meiosis by degrading a specific mRNA required for sexual development; yeast ribonuclease III (gene RNT1). dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites; Caenorhabditis elegans hypothetical protein F26E4.13; Paramecium bursaria chlorella virus 1 protein A464R; Synechocystis strain PCC 6803 hypothetical protein slr0346; fission yeast hypothetical protein SpAC8A4.08c. protein with a N-terminal helicase domain and a C-terminal RNase III domain; andCaenorhabditis elegans hypothetical protein K12H4.8. protein with the same structure as SpAC8A4.08c.
  IPR000999:Ribonuclease III
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR011545:DEAD/DEAH box helicase, N-terminal
The DsRBD domain is found in a variety of RNA-binding proteins with differentstructures and exhibiting a diversity of functions .It is involved in localization of at least five different mRNAs in the early Drosophila embryo and by interferon-induced protein kinase in humans.hich is part of the cellular response to dsRNA.
  IPR001159:Double-stranded RNA binding
IPR005034:DUF283 
Evalue:-62.1804542541504 
Location:620-712IPR000999:RIBOc 
Evalue:-48.0861861476163 
Location:1671-1837IPR003100:PAZ 
Evalue:-40.9586067199707 
Location:881-1055IPR000999:RIBOc 
Evalue:-34.9586073148418 
Location:1285-1586IPR014001:DEXDc 
Evalue:-22.8538719643218 
Location:30-239IPR001650:Helicase_C 
Evalue:-16.3767509460449 
Location:489-546IPR001159:DSRM 
Evalue:-8.14874165128092 
Location:1840-1903
SequencesProtein: DICER_HUMAN (1912 aa)
mRNA: AJ132261 NM_177438
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK01165
  Level 3 annotation:
    
  Level 2 annotation:
    Other enzymes
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 1479 residues, 94622318-94626753Exon2: 27 residues, 94627123-94627199Exon3: 56 residues, 94627292-94627455Exon4: 91 residues, 94629977-94630246Exon5: 298 residues, 94631914-94632803Exon6: 54 residues, 94635869-94636025Exon7: 262 residues, 94639435-94640216Exon8: 60 residues, 94641160-94641336Exon9: 37 residues, 94641767-94641873Exon10: 63 residues, 94642130-94642313Exon11: 53 residues, 94643697-94643851Exon12: 73 residues, 94643969-94644183Exon13: 62 residues, 94644413-94644593Exon14: 48 residues, 94647406-94647546Exon15: 27 residues, 94648261-94648337Exon16: 46 residues, 94649181-94649314Exon17: 53 residues, 94651756-94651911Exon18: 83 residues, 94652542-94652785Exon19: 46 residues, 94653711-94653844Exon20: 159 residues, 94660285-94660758Exon21: 58 residues, 94662669-94662838Exon22: 55 residues, 94665561-94665722Exon23: 47 residues, 94666147-94666282Exon24: 45 residues, 94667598-94667729Exon25: 56 residues, 94668604-94668767Exon26: 65 residues, 94669404-94669593Exon27: 66 residues, 94693319-94693512Exon28: 2 residues, -Jump to DICER_HUMANExon1: 113 residues, 94626416-94626753Exon2: 27 residues, 94627123-94627199Exon3: 56 residues, 94627292-94627455Exon4: 91 residues, 94629977-94630246Exon5: 298 residues, 94631914-94632803Exon6: 54 residues, 94635869-94636025Exon7: 262 residues, 94639435-94640216Exon8: 60 residues, 94641160-94641336Exon9: 37 residues, 94641767-94641873Exon10: 63 residues, 94642130-94642313Exon11: 53 residues, 94643697-94643851Exon12: 73 residues, 94643969-94644183Exon13: 62 residues, 94644413-94644593Exon14: 48 residues, 94647406-94647546Exon15: 27 residues, 94648261-94648337Exon16: 46 residues, 94649181-94649314Exon17: 53 residues, 94651756-94651911Exon18: 83 residues, 94652542-94652785Exon19: 46 residues, 94653711-94653844Exon20: 159 residues, 94660285-94660758Exon21: 58 residues, 94662669-94662838Exon22: 55 residues, 94665561-94665722Exon23: 47 residues, 94666147-94666282Exon24: 45 residues, 94667598-94667729Exon25: 56 residues, 94668604-94668767Exon26: 65 residues, 94669404-94669593Exon27: 64 residues, 94672712-94672900Exon28: 2 residues, -Jump to DICER_HUMAN  
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