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0DHX34_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDHX34
DescriptionProbable atp-dependent helicase dhx34 (deah-box protein 34).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GON/A
Domain Architecture (Details)
InterPro domains unassigned to SynO:
This entry is found in DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism.ncluding nuclear transcription.re mRNA splicing.ibosome biogenesis.ucleocytoplasmic transport.ranslation.NA decay and organellar gene expression.
  IPR014001:DEAD-like helicases, N-terminal
This presumed domain is about 90 amino acid residues in length. It is found as a diverse set of RNA helicases. Its function is unknown.owever it seems likely to be involved in nucleic acid binding.
  IPR007502:Helicase-associated region
The domain.hich defines this group of proteins is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit.ut an integral part of the helicase.The eukaryotic translation initiation factor 4A (eIF4A) is a member of the DEA(D/H)-box RNA helicase family This is a diverse group of proteins that couples an ATPase activity to RNA binding and unwinding. The structure of the carboxyl-terminal domain of eIF4A has been determined to 1.75 A resolution; it has a parallel alpha-beta topology that superimposes.ith minor variations.n the structures and conserved motifs of the equivalent domain in other.istantly related helicases .
  IPR001650:Helicase, C-terminal
IPR014001:DEXDc 
Evalue:-28.2757241303992 
Location:148-341IPR007502:HA2 
Evalue:-16.3010292053223 
Location:471-535IPR001650:Helicase_C 
Evalue:-9.72124671936035 
Location:347-411IPR002464:DEAH_ATP_HELICASE 
Evalue:0 
Location:0-0
SequencesProtein: DHX34_HUMAN (576 aa)
mRNA: D50924 NM_014681 NM_194428
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentNot mapped to KEGG
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 22 residues, 52544385-52544449Exon2: 329 residues, 52547850-52548832Exon3: 106 residues, 52550135-52550447Exon4: 87 residues, 52552960-52553215Exon5: 36 residues, 52555065-52555168Exon6: 74 residues, 52557576-52557794Exon7: 60 residues, 52562072-52562247Exon8: 66 residues, 52567800-52567994Exon9: 36 residues, 52568655-52568757Exon10: 83 residues, 52570521-52570764Exon11: 60 residues, 52570978-52571152Exon12: 41 residues, 52571497-52571615Exon13: 27 residues, 52571969-52572044Exon14: 37 residues, 52572154-52572261Exon15: 94 residues, 52574797-52575073Exon16: 61 residues, 52575903-52576080Exon17: 48 residues, 52576273-52576412Exon18: 244 residues, 52577067-52577795Exon19: 2 residues, -Jump to DHX34_HUMANExon1: 22 residues, 52544385-52544449Exon2: 329 residues, 52547850-52548832Exon3: 106 residues, 52550135-52550447Exon4: 87 residues, 52552960-52553215Exon5: 36 residues, 52555065-52555168Exon6: 74 residues, 52557576-52557794Exon7: 60 residues, 52562072-52562247Exon8: 66 residues, 52567800-52567994Exon9: 36 residues, 52568655-52568757Exon10: 83 residues, 52570521-52570764Exon11: 60 residues, 52570978-52571152Exon12: 41 residues, 52571497-52571615Exon13: 37 residues, 52572154-52572261Exon14: 94 residues, 52574797-52575073Exon15: 61 residues, 52575903-52576080Exon16: 48 residues, 52576273-52576412Exon17: 244 residues, 52577067-52577795Exon18: 2 residues, -Jump to DHX34_HUMANExon1: 328 residues, 52547850-52548832Exon2: 106 residues, 52550135-52550447Exon3: 36 residues, 52555065-52555168Exon4: 74 residues, 52557576-52557794Exon5: 60 residues, 52562072-52562247Exon6: 39 residues, 52567800-52567912Exon7: 31 residues, 52571527-52571615Exon8: 37 residues, 52572154-52572261Exon9: 94 residues, 52574797-52575073Exon10: 61 residues, 52575903-52576080Exon11: 48 residues, 52576273-52576412Exon12: 240 residues, 52577067-52577783Exon13: 313 residues, 52580782-52581716Exon14: 2 residues, -Jump to DHX34_HUMAN  
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Loci Cluster (Details)Loci: 4405 52682702-52710309 ~-28K 19191(NAPA)(-)Loci: 3122 52544385-52581716 ~-37K 19180(DHX34)(+)Link out to UCSC