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0DHRS3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDHRS3
DescriptionShort-chain dehydrogenase/reductase 3 (ec 1.1.-.-) (retinal short- chain dehydrogenase/reductase 1) (retsdr1) (dd83.1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005489 electron transporter activity (TAS)
0000166 nucleotide binding (TAS)
0006631 fatty acid metabolism (TAS)
0007601 visual perception (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes.ost of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterized was Drosophila alcohol dehydrogenase.his family used to be called insect-type.r short-chain alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains .he first binding the coenzyme.ften NAD.nd the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity.nd it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains .
  IPR002198:Short-chain dehydrogenase/reductase SDR
Glucose dehydrogenase catalyses the oxidation of D-glucose without priorphosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme.The enzyme is a tetrameric protein.ach of the 4 identical subunitscontaining 262 amino acid residues. This family is a subset of a more general family of short-chain dehydrogenases andreductases.A match to this extension indicates that the protein is notan alcohol dehydrogenase.ut another type of dehydrogenaseor reductase.
  IPR002347:Glucose/ribitol dehydrogenase
IPR002198:adh_short 
Evalue:-25.9586067199707 
Location:39-207IPR002347:GDHRDH 
Evalue:0 
Location:210-227IPR002198:ADH_SHORT 
Evalue:0 
Location:0-0
SequencesProtein: DHRS3_HUMAN (302 aa)
mRNA: NM_004753
Local Annotation
Synapse Ontology
introduce the substructure of the synapse and the location where the molecule can be seen. It will contain all the constructive special organelle and molecule we known.
sdb:0001 Structure/Biochemistry of synapse  (Evidence:keywords)
KO assignmentK00120
  Level 3 annotation:
    
  Level 2 annotation:
    Limonene and pinene degradation
    gamma-Hexachlorocyclohexane degradation
    1
    1
    1-Trichloro-2
    2-bis(4-chlorophenyl)ethane (DDT) degradation
    Ethylbenzene degradation
    Benzoate degradation via CoA ligation
    Bisphenol A degradation
    1- and 2-Methylnaphthalene degradation
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 172 residues, 12550526-12551040Exon2: 44 residues, 12555342-12555468Exon3: 81 residues, 12561332-12561571Exon4: 42 residues, 12561907-12562027Exon5: 50 residues, 12563137-12563281Exon6: 222 residues, 12599745-12600407Exon7: 2 residues, -Jump to DHRS3_HUMAN  
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