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0DHPR_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameQDPR
DescriptionDihydropteridine reductase (ec 1.5.1.34) (hdhpr) (quinoid dihydropteridine reductase).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0004155 6,7-dihydropteridine reductase activity (TAS)
0005489 electron transporter activity (TAS)
0006520 amino acid metabolism (TAS)
0051066 dihydrobiopterin metabolism (TAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes.ost of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterized was Drosophila alcohol dehydrogenase.his family used to be called insect-type.r short-chain alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains .he first binding the coenzyme.ften NAD.nd the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity.nd it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains .
  IPR002198:Short-chain dehydrogenase/reductase SDR
IPR002198:adh_short 
Evalue:-2.67778062820435 
Location:11-169
SequencesProtein: DHPR_HUMAN (244 aa)
mRNA: NM_000320
Local Annotation
Synapse Ontology
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK00357
  Level 3 annotation:
    dihydropteridine reductase
  Level 2 annotation:
    Folate biosynthesis
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 280 residues, 17097120-17097957Exon2: 30 residues, 17101382-17101466Exon3: 38 residues, 17102952-17103061Exon4: 49 residues, 17112439-17112580Exon5: 34 residues, 17115099-17115196Exon6: 33 residues, 17119991-17120084Exon7: 49 residues, 17122670-17122811Exon8: 2 residues, -Jump to DHPR_HUMAN  
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Loci Cluster (Details)Loci: 3406 17421622-17455583 ~-34K 27407(CAPG)(+)Loci: 4666 17491890-17495261 ~-3K 27409(-)Loci: 4665 17097120-17122811 ~-26K 27403(QDPR)(-)Link out to UCSC