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0DHI1_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameHSD11B1
DescriptionCorticosteroid 11-beta-dehydrogenase, isozyme 1 (ec 1.1.1.146) (11-dh) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-hsd1).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005789 endoplasmic reticulum membrane (IDA)
0003845 11-beta-hydroxysteroid dehydrogenase activity (IDA)
0008211 glucocorticoid metabolism (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes.ost of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterized was Drosophila alcohol dehydrogenase.his family used to be called insect-type.r short-chain alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains .he first binding the coenzyme.ften NAD.nd the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. Little sequence similarity has been found in the coenzyme binding domain although there is a large degree of structural similarity.nd it has therefore been suggested that the structure of dehydrogenases has arisen through gene fusion of a common ancestral coenzyme nucleotide sequence with various substrate specific domains .
  IPR002198:Short-chain dehydrogenase/reductase SDR
Glucose dehydrogenase catalyses the oxidation of D-glucose without priorphosphorylation to D-beta-gluconolactone using NAD or NADP as a coenzyme.The enzyme is a tetrameric protein.ach of the 4 identical subunitscontaining 262 amino acid residues. This family is a subset of a more general family of short-chain dehydrogenases andreductases.A match to this extension indicates that the protein is notan alcohol dehydrogenase.ut another type of dehydrogenaseor reductase.
  IPR002347:Glucose/ribitol dehydrogenase
IPR002198:adh_short 
Evalue:-29.9586067199707 
Location:34-201
SequencesProtein: DHI1_HUMAN (291 aa)
mRNA: NM_181755
Local Annotation
Synapse Ontology
Microglias, one kind of glias in CNS, are responsible for removing most of the waste and cellular debris from the CNS
sdb:0267 removing metabolic mass  (Evidence:keywords)
KO assignmentK00071
  Level 3 annotation:
    11beta-hydroxysteroid dehydrogenase
  Level 2 annotation:
    C21-Steroid hormone metabolism
    Androgen and estrogen metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 28 residues, 207926172-207926253Exon2: 40 residues, 207944884-207944998Exon3: 45 residues, 207945778-207945909Exon4: 39 residues, 207946676-207946788Exon5: 64 residues, 207946910-207947096Exon6: 50 residues, 207972403-207972547Exon7: 217 residues, 207974271-207974917Exon8: 2 residues, -Jump to DHI1_HUMAN  
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Loci Cluster (Details)Loci: 2587 207926172-207974917 ~-49K 3858(HSD11B1)(+)Loci: 2588 208178218-208402294 ~-224K 3867(SYT14)(+)Loci: 2586 207823667-207853906 ~-30K 3854(CAMK1G)(+)Link out to UCSC