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0DHE3_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameGLUD1
DescriptionGlutamate dehydrogenase 1, mitochondrial precursor (ec 1.4.1.3) (gdh).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0006538 glutamate catabolism (TAS)
0007169 transmembrane receptor protein tyrosine kin... (NAS)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
Glutamate.eucine.henylalanine and valine dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue.hich has been implicated in the catalytic activity.n each case a reversible oxidative deamination reaction.Glutamate dehydrogenases ( and ) (GluDH) are enzymes that catalyze the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate . GluDH isozymes are generally involved with either ammonia assimilation or glutamate catabolism. Two separate enzymes are present in yeasts: the NADP-dependent enzyme.hich catalyses the amination of alpha-ketoglutarate to L-glutamate; and the NAD-dependent enzyme.hich catalyses the reverse reaction - this form links the L-amino acids with the Krebs cycle.hich provides a major pathway for metabolic interconversion of alpha-amino acids and alpha- keto acids .Leucine dehydrogenase () (LeuDH) is a NAD-dependent enzyme that catalyzes the reversible deamination of leucine and several other aliphatic amino acids to their keto analogues . Each subunit of this octameric enzyme from Bacillus sphaericus contains 364 amino acids and folds into two domains.eparated by a deep cleft. The nicotinamide ring of the NAD+ cofactor binds deep in this cleft.hich is thought to close during the hydride transfer step of the catalytic cycle.
  IPR006097:Glu/Leu/Phe/Val dehydrogenase, dimerisation region
Glutamate.eucine.henylalanine and valine dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue.hich has been implicated in the catalytic activity.n each case a reversible oxidative deamination reaction.Glutamate dehydrogenases ( and ) (GluDH) are enzymes that catalyze the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate . GluDH isozymes are generally involved with either ammonia assimilation or glutamate catabolism. Two separate enzymes are present in yeasts: the NADP-dependent enzyme.hich catalyses the amination of alpha-ketoglutarate to L-glutamate; and the NAD-dependent enzyme.hich catalyses the reverse reaction - this form links the L-amino acids with the Krebs cycle.hich provides a major pathway for metabolic interconversion of alpha-amino acids and alpha- keto acids .Leucine dehydrogenase () (LeuDH) is a NAD-dependent enzyme that catalyzes the reversible deamination of leucine and several other aliphatic amino acids to their keto analogues . Each subunit of this octameric enzyme from Bacillus sphaericus contains 364 amino acids and folds into two domains.eparated by a deep cleft. The nicotinamide ring of the NAD+ cofactor binds deep in this cleft.hich is thought to close during the hydride transfer step of the catalytic cycle.
  IPR006096:Glu/Leu/Phe/Val dehydrogenase, C-terminal
Glutamate.eucine.henylalanine and valine dehydrogenases are structurally and functionally related. They contain a Gly-rich region containing a conserved Lys residue.hich has been implicated in the catalytic activity.n each case a reversible oxidative deamination reaction.Glutamate dehydrogenases ( and ) (GluDH) are enzymes that catalyze the NAD- and/or NADP-dependent reversible deamination of L-glutamate into alpha-ketoglutarate . GluDH isozymes are generally involved with either ammonia assimilation or glutamate catabolism. Two separate enzymes are present in yeasts: the NADP-dependent enzyme.hich catalyses the amination of alpha-ketoglutarate to L-glutamate; and the NAD-dependent enzyme.hich catalyses the reverse reaction - this form links the L-amino acids with the Krebs cycle.hich provides a major pathway for metabolic interconversion of alpha-amino acids and alpha- keto acids .Leucine dehydrogenase () (LeuDH) is a NAD-dependent enzyme that catalyzes the reversible deamination of leucine and several other aliphatic amino acids to their keto analogues . Each subunit of this octameric enzyme from Bacillus sphaericus contains 364 amino acids and folds into two domains.eparated by a deep cleft. The nicotinamide ring of the NAD+ cofactor binds deep in this cleft.hich is thought to close during the hydride transfer step of the catalytic cycle.
  IPR006095:Glu/Leu/Phe/Val dehydrogenase
IPR006097:ELFV_dehydrog_N 
Evalue:-75.2757263183594 
Location:112-244IPR006096:ELFV_dehydrog 
Evalue:-64.4202194213867 
Location:263-554
SequencesProtein: DHE3_HUMAN (558 aa)
mRNA: NM_005271
Local Annotation
Synapse Ontology
mitochondria are frequently observed in the vicinity of the synaptic vesicle clusters, in agreement with the ATP requirement of several steps of the vesicle cycle.
sdb:0118 mitochondria  (Evidence:keywords)
?
sdb:0328 transmitters release and endocytosis  (Evidence:keywords)
KO assignmentK00261
  Level 3 annotation:
    glutamate dehydrogenase (NAD(P)+)
  Level 2 annotation:
    Nitrogen metabolism
    Glutamate metabolism
    Arginine and proline metabolism
    Urea cycle and metabolism of amino groups
    D-Glutamine and D-glutamate metabolism
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 462 residues, 88800222-88801607Exon2: 23 residues, 88803078-88803141Exon3: 32 residues, 88807427-88807519Exon4: 43 residues, 88808886-88809010Exon5: 29 residues, 88809897-88809978Exon6: 48 residues, 88810424-88810562Exon7: 48 residues, 88810651-88810789Exon8: 62 residues, 88812392-88812572Exon9: 33 residues, 88817799-88817894Exon10: 23 residues, 88824287-88824351Exon11: 20 residues, 88825704-88825760Exon12: 29 residues, 88826312-88826393Exon13: 182 residues, 88844061-88844603Exon14: 2 residues, -Jump to DHE3_HUMAN  
Tune and view alternative isoforms
Loci Cluster (Details)Loci: 3904 88800222-88844603 ~-44K 5265(GLUD1)(-)Loci: 2624 88708392-88712995 ~-5K 5262(SNCG)(+)Link out to UCSC