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0DHCR7_HUMAN*   SwissProt (?) | Description Local Annotation Link Reference
General Information
NameDHCR7
Description7-dehydrocholesterol reductase (ec 1.3.1.21) (7-dhc reductase) (sterol delta-7-reductase) (putative sterol reductase sr-2).
SpeciesHomo sapiens (NCBI taxonomy ID: 9606)
GO0005783 endoplasmic reticulum (IDA)
0005640 nuclear outer membrane (IDA)
0047598 7-dehydrocholesterol reductase activity (IDA)
0006695 cholesterol biosynthesis (IMP)

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schematic display of those terms with internal associations, click the node and browse the corresponding GO term
Domain Architecture (Details)
InterPro domains unassigned to SynO:
The two fungal enzymes.-14 sterol reductase (gene ERG24 in budding yeast and erg3 inNeurospora Crassa) and C-24(28) sterol reductase (gene ERG4 in budding yeast and sts1in fission yeast).re involved in ergosterol biosynthesis. They act by reducingdouble bonds in precursors of ergosterol .These proteins are highly hydrophobic and seem to contain seven or eight transmembraneregions. Chicken lamin B receptor that is thought to anchor the lamina to the innernuclear membrane belongs to this family.
  IPR001171:ERG4/ERG24 ergosterol biosynthesis protein
This family contains proteins which have a Greek key motif . They are all structurally related to the beta.amma crystallin superfamily. This family of proteins includes:Beta and gamma crystallinsYeast killer toxinKiller toxin-like protein SKLPAntifungal protein.FP1Plant antimicrobial protein.IAMP1Streptomyces metalloproteinase inhibitor.MPI . SMPI belongs to MEROPS inhibitor I36.lan IU. It inhibits members of the thermolysin family.EROPS peptidase family M4.) . The SSF signature in this entry is currently under review. Please be aware that some of the protein hits may be false positives.
  IPR011024:Gamma-crystallin related
IPR001171:ERG4_ERG24 
Evalue:-80.7695541381836 
Location:142-475
SequencesProtein: DHCR7_HUMAN (475 aa)
mRNA: NM_001360
Local Annotation
Synapse Ontology
Calcium release from RyR (Ryanodine Receptor) in the SR (Sarcoplasmic Reticulum) is activated by the calcium induced-calcium-release
sdb:0325 RyR-CICR  (Evidence:keywords)
KO assignmentK00213
  Level 3 annotation:
    7-dehydrocholesterol reductase
  Level 2 annotation:
    Biosynthesis of steroids
Loci Structure (Details)Loci index, Chromosomal location, Length, Possible relational loci clusterExon1: 475 residues, 70823110-70824533Exon2: 46 residues, 70826505-70826637Exon3: 70 residues, 70827572-70827777Exon4: 73 residues, 70829920-70830134Exon5: 32 residues, 70830956-70831047Exon6: 76 residues, 70832686-70832909Exon7: 36 residues, 70833548-70833652Exon8: 43 residues, 70836303-70836428Exon9: 23 residues, 70836983-70837047Exon10: 2 residues, -Jump to DHCR7_HUMAN  
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Loci Cluster (Details)Loci: 2692 70954256-70955314 ~-1K 7318(KRTAP5-10)(+)Loci: 3969 70823110-70837047 ~-14K 7312(DHCR7)(-)Link out to UCSC